Protein Alignment Dcr-1 and dicer1

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: NP_001154925.2
• Gene: dicer1 / 324724
• ZFINID: ZDB-GENE-030131-3445
• Length: 1865
• Species: Danio rerio
• Alignment Length: 2410
• Identity: 780/2410 - (32%)
• Similarity: 1089/2410 - (45%)
• Gaps: 749/2410 - (31%)

  Fly     5 WCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR-RHGRVSVYL 68
            |....:|..::|||.:|||||..|.|.|||:||...|.|.|||:.|::|||.:.| .:|:.:|:|
Zfish    22 WQQEAIHDNIYTPRKYQVELLEAALEHNTIVCLNTGSGKTFIAVLLIKELSHQIRGENGKRTVFL 86

  Fly    69 SCEVGTSTEPCSIYTMLTHLTDLRV----------WQEQPDMQIPFDHCWT----DYHVSILRPE 119
            .....:..:..|  |:.|| :||:|          |.|:         .|.    :..|.::...
Zfish    87 VNAASSVAQQAS--TVRTH-SDLQVGDYMSEDMTSWPEE---------MWNREMIENQVLVMTCH 139

  Fly   120 GFLYLLETRELLLSSVELIVLEDCHDSAV---YQRIRPLFENHIMPAPPADRPRILGLAGPLHSA 181
            .||::|:...|.||.:.|:|.::||.:..   |:.|..:.|.    .|..  ||||||...:.:.
Zfish   140 IFLHVLKNGVLPLSKINLLVFDECHLAITGHPYREIMKICEG----CPSC--PRILGLTASILNG 198

  Fly   182 GCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPF-EMDELSLVLADVLNTH 245
            .|:...|...:..||:.:....|||:|:|.:.||.|:|.|.::.|..: :...||..|.:.|:..
Zfish   199 KCDPCDLEEKIQNLEKILQSNAETATDLVVLDRYASQPREEVLDCGQYQDQSGLSERLLNELDEA 263

  Fly   246 KSFLLD-----HRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAHHF 305
            .|||.|     ||.|                 .||......|:|....||..:||||..:||...
Zfish   264 LSFLNDCNLSVHRED-----------------RDPTFISKQVLNDCRAVLTVLGPWCADKAAGIM 311

  Fly   306 YQCNEKLKVKTPHE-----RHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIE-RYSSPK 364
            .:   :|:....||     |.:||:  ..|.|.::::|||..|         |..::: ::.:||
Zfish   312 VR---ELQKYIKHEQEELNRKFLLF--TDTILRKIHALCEEHF---------SPASLDLKFVTPK 362

  Fly   365 VRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADF--NRLSHTLESKCRMVDQMDQPPTETRALV 427
            |.|||:.|..:||.|           |.|.:..::  ||
Zfish   363 VIRLLEILHEYKPFE-----------RQQFESVEWYNNR-------------------------- 390

  Fly   428 ATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDT 492
                     .:|...:.|.:........|.||.|  :.||...|.|                 :.
Zfish   391 ---------NQDNYVSWSDSEDDDEDEEAEAKEK--TEANFPSPFT-----------------NI 427

  Fly   493 LCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAELEHRRQEEVLK 556
            ||.:|:..:.:||.||..|:.|..::||:|.::...:.|.. :.......|:.|:|.|:|||||:
Zfish   428 LCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHSIGKNQPRNKQMEVEFRKQEEVLR 492

  Fly   557 RFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSYKSP 621
            :||.|:.|:||.||::|||:|:||||||||:|.||.||||||.||||||..:.:::|
Zfish   493 KFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPVSNYIML-------- 549

  Fly   622 TVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQPPT 686
                                   |||
Zfish   550 -----------------------ADS--------------------------------------- 552

  Fly   687 ACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTSDTT 751
                                                      ::::.||.:|.:
Zfish   553 ------------------------------------------ERTKTFQEDLKT----------- 564

  Fly   752 AEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANT--------EPPEQEQSEAERFSACLAAY 808
                                  |:.||::|.:||:.:        ||...:.:..
Zfish   565 ----------------------YKAIEKILRNKCSKSAECNDFELEPVTDDDNVL---------- 597

  Fly   809 RPKPHLLT----GASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPI 869
              .|::|.    |..|.:.:||..||:||||||||.||.|....:.......|   ::.||.|||
Zfish   598 --PPYVLRSEDGGPRVTMNTAIGHVNRYCARLPSDPFTHLAPKCKTVEMNTGG---YRSTLFLPI 657

  Fly   870 NSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPED 934
            ||||:..:.|..|....||.:..||..|.:||:||||||.|.|:|||..:..|      ||:..|
Zfish   658 NSPLRVPVTGPVMNCARLAEKAVALLCCEKLHKIGELDDHLMPVGKETVKYEE------ELDLHD 716

  Fly   935 EQIVQLSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIY 999
            |:  :.|...|||:|||||.|.|.|......|.||...|||||.|.:.|..|:|:|.|.|.||:|
Zfish   717 EE--ETSVPGRPGSTKRRQCYPKAIPECLRGCYPVPEQPCYLYVIGMVLTTPLPDELNFRRRKLY 779

  Fly  1000 PPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVL 1064
            ||||..:.|||||.|.||::..|.::||||||.:|:||.|....|::||:..|.....|.|:::|
Zfish   780 PPEDTTRCFGILTAKPIPRIPHFPVYTRSGEVTISIELQKSGFSLSAEQLELITRLHQYIFSHIL 844

  Fly  1065 RLQKFLMLFDPDSTENCVFIVP-TVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQP--- 1125
            ||:|..:.|.|...::...::| .:...:....:|::|:|.|:.:...:  .:|:.:...|.
Zfish   845 RLEKPALEFKPVEADSAYCVLPLNIVEDSNTLDLDFKFMEDIEKSEARI--GIPNTQYTKQNPFI 907

  Fly  1126 FDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQP 1190
            |..:.:||||::|.|||.|||..||||::...|:|||.||...|.||..||..||.|.:.|.:||
Zfish   908 FKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLSNVNQP 972

  Fly  1191 LLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTA 1255
            ||||||||:|||.||||::|:||.|||.||.|.::||.|:|:.|||||||||.:||.||||||.|
Zfish   973 LLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKA 1037

  Fly  1256 VCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKES 1320
            ||||.||||::.||.|:::|.|.:.|.|:|.|.: ..||.:|.|||||      |||.:||...|
Zfish  1038 VCLPSILYRLHCLLTAEELRSQTAIDAGVGAQTL-PPDFRYPNLDFGW------KKSIDSKSFIS 1095

  Fly  1321 LKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTW--SN 1383
            .                |::                           .::|.||..::||.  ||
Zfish  1096 C----------------PSA---------------------------CMEEDDDHCKLGTSSDSN 1117

  Fly  1384 DMADDIASFN---------QEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGP 1439
            ..|.:..|..         ...|::.:...|||...| |.|          |.::.|
Zfish  1118 HTAPESCSMEVSQPPDGALNTPDEKLETLALPVTDLN-KDC----------FPNLPN-------- 1163

  Fly  1440 KSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGR 1504
                                          |:..|.||       :.|.     .||......|.
Zfish  1164 ------------------------------GTQADSDD-------LPHR-----SDVCQCSQLGP 1186

  Fly  1505 IAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEE 1569
            :                    ::.||....|:.:.|.
Zfish  1187 L--------------------ERDLSTQTTTSVSVRP---------------------------- 1203

  Fly  1570 SIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRREL 1634
                                      |.|.|.|              |:.:::...:.
Zfish  1204 --------------------------SPAGEPQ--------------PWPSDECTGRS------- 1221

  Fly  1635 LLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTS----- 1694
              |||                    |        |.|                 ::.|||
Zfish  1222 --SDL--------------------C--------DPH-----------------VKKPTSKHCPK 1239

  Fly  1695 TKAITSAILP------------AGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETI 1747
            ::..||...|            ||.::|....|    ||:|.:||||||:|||:||.||||||.:
Zfish  1240 SETATSTAAPSETSSEDCRSACAGPAWDSPKTL----GPNPGLILQALTLSNASDGFNLERLEML 1300

  Fly  1748 GDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPP 1812
            ||||||:||||||:.||.:.|||:||::|||:|:|.||||||::|.|...|:.:.|:|..|||||
Zfish  1301 GDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPP 1365

  Fly  1813 CYYV----------------------------------PKELE---------------------- 1821
            .|.|                                  |:|.|
Zfish  1366 GYVVNQDKSSTDKWDSDENKDLANGKASDDEDEDDDDEPEEAEVEPSKEDVNVEDDLEYYYEHIR 1430

  Fly  1822 --------------KALIEAKIPTHHWKL--------------ADLLDIKNLSSVQICEMVREKA 1858
                          |..::...|.:.||.              ||..|..:..:  :|.:...||
Zfish  1431 FIDSMLIGSGAFGKKISLQPTDPGYEWKAPKKAHNSHFSPDGGADEFDYSSWDA--MCYLDPSKA 1493

  Fly  1859 D-----ALGL----EQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAY 1914
            .     .:|.    |:|.|...|:..            |.|:|.::..|.|||||||||||:|.|
Zfish  1494 GEEDDFVVGFWNPSEENCGTDIGKQS------------ISYDLHTEQCIADKSIADCVEALLGCY 1546

  Fly  1915 LIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAW---PTPRSPLL 1976
            |..||.|.|.||:..||::|||..:|..||:.|.:               || |   | ||....
Zfish  1547 LTSCGERAAQLFLCSLGLKVLPPEKQSSGGSAELQ---------------YG-WLKIP-PRCMFE 1594

  Fly  1977 HFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLGDAVLDY 2041
            |  |:|...|:.|:|||..||..:.|.|::::|||||.|||||..|.:|||||||||||||:|||
Zfish  1595 H--PDAERTLNHLISGFLNFESKINYTFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDY 1657

  Fly  2042 LITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQEN 2106
            |||:||||||||||||.|||||||||||||||||||::.:||:|:.:||.|..|||.||:.|.|.
Zfish  1658 LITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEK 1722

  Fly  2107 GHCISEEYYL-LSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQ 2170
            ......:..| .|||:.:..||:|||||:||:|||:||||::||.|||:.||.||..||.|.||:
Zfish  1723 NEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEK 1787

  Fly  2171 FSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRIAKCTAAKCA 2235
            ||.:||:||:|||||:|||||||...|:..|| :|||||:|..||.|:|:||:|||||..||:.|
Zfish  1788 FSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRIAKSAAARRA 1851

  Fly  2236 LRQLK 2240
            ||.||
Zfish  1852 LRSLK 1856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	66/210 (31%)
		Dicer_PBD	240..344	CDD:277191	31/113 (27%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	57/124 (46%)
		Dicer_dimer	825..916	CDD:460900	43/90 (48%)
		PAZ_dicer_like	1091..1212	CDD:239209	55/123 (45%)
		RIBOc	1724..1930	CDD:238333	101/298 (34%)
		RIBOc	2008..2172	CDD:238333	108/164 (66%)
		DSRM_DICER	2177..2240	CDD:380680	39/62 (63%)
dicer1	NP_001154925.2	DECH box	161..164		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..417		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..732		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1111..1142		7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1190..1259		21/190 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1373..1417		3/43 (7%)