DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and Drosha

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_001101125.2	Gene:	Drosha / 310159	RGDID:	1307626	Length:	1373	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	162/759 - (21%)
Similarity:	265/759 - (34%)	Gaps:	266/759 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1548 LLIGFNFKHEDQKEPATIRYE---------ESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQV 1603
            :::.|..:      ||.:.|.         :|..||:..:.:...:...|:|.:.:|.:|.:...
  Rat   770 IIVHFGIR------PAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIR 828

  Fly  1604 AKVSM-----MELLKQ----------------LLPYVNEDV--------LAKKLG----DRRELL 1635
            .|.:|     :||..|                :||.:...:        |.|.:|    ||
  Rat   829 QKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDR---- 889

  Fly  1636 LSDLVELNADWVARH-------EQETYNVMGCGDSFDNYNDH--HRLNLDEKQLKLQYERIEIEP 1691
              .|::|.....:.|       :....::..||.....|.|.  |.:::.:|.:.....
  Rat   890 --CLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLIN------ 946

  Fly  1692 PTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAI 1756
                  |.|.:              |...|:||.|       |.|     ||||.:||:.:::..
  Rat   947 ------IMSRL--------------GQDDPTPSRI-------NHN-----ERLEFLGDAVVEFLT 979

  Fly  1757 TTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELE 1821
            :.:||..:.::.||.|:..|:..|.|.:|           .|:|.|.               ||:
  Rat   980 SVHLYYLFPSLEEGGLATYRTAIVQNQHL-----------AMLAKKL---------------ELD 1018

  Fly  1822 KALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSC 1886
            :.::.|..|                                                |.|.:...
  Rat  1019 RFMLYAHGP------------------------------------------------DLCRESDL 1035

  Fly  1887 FIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIP 1951
                    :|     ::|:|.||||||..:|    |.|.....|..|:|
  Rat  1036 --------RH-----AMANCFEALIGAVYLE----GTLEEAKQLFGRLL---------------- 1067

  Fly  1952 GSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEEL---DQLLSGFEEFEESLGYKFRDRSYLLQA 2013
             ...|:...|...|     |..||....||...:|   ..:|....||||::|..|.....|.:|
  Rat  1068 -FNDPDLREVWLNY-----PLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARA 1126

  Fly  2014 MTHASYTPNRLTDCY-QRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAV 2077
            .|..:...|.||..: ||:|||||:::..:.|.:|:.....|..|.||.|||:||||...|.:|.
  Rat  1127 FTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAE 1191

  Fly  2078 RHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIA 2142
            ..|..::     ...||...|.|.::                           .|.|.|:.||..
  Rat  1192 ELGMQEY-----AITNDKTKRPVALR---------------------------TKTLADLLESFI 1224

  Fly  2143 GAIFLDSNMSLDVVWHVYSNM-MSPEIEQF----SNSVPKSPIRE-LLEL-----EPETAKFGKP 2196
            .|:::|.:  |:.| |.:.|: ..|.:::|    ..:.|||.::: .|.|     ||:...:...
  Rat  1225 AALYIDKD--LEYV-HTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTL 1286

  Fly  2197 EKLADGRRVRVTVDVFCKGTFRGIGRNYRI--AKCTAAKCALRQ 2238
            :.:........||.|:.||...|.|:...|  |:..||..||.:
  Rat  1287 QTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEK 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333	40/205 (20%)
		RIBOc	2008..2172	CDD:238333	46/169 (27%)
		DSRM_DICER	2177..2240	CDD:380680	19/70 (27%)
Drosha	NP_001101125.2	SF-CC1	212..>274	CDD:273721
		RIBOc	958..1078	CDD:238333	46/239 (19%)
		rnc	1104..1332	CDD:234633	72/262 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810