DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcr-1 and Mrpl44

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_001026820.1	Gene:	Mrpl44 / 301552	RGDID:	1309556	Length:	332	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	68/321 - (21%)
Similarity:	122/321 - (38%)	Gaps:	81/321 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1971 PRSPLLHFAPNATEELDQLLSGFE---EFEESLGYKFRDRSYLLQA---MTHASYTPNRLTDCYQ 2029
            ||..|...||.....:..:..||.   .|::.|     :|..||::   ....|..||  .|.:.
  Rat    13 PRRLLAPAAPTLVPPVRGVKKGFRAAFRFQKEL-----ERWRLLRSPPPPVRRSEKPN--WDYHA 70

  Fly  2030 RLEFLGDAV-----LDYLITRHL------YEDPRQHSPG-----ALTDLRSALVNNTIF-ASLAV 2077
            .::..|..:     ||.|.|..:      .|:.::.:.|     ||.:|:.   |..:| ..|:.
  Rat    71 EIQAFGSRLQEAFSLDLLKTAFVNSCYIKSEEAKRQNLGIEKEAALLNLKD---NQELFEQGLSF 132

  Fly  2078 RHG-FHKFFRHLSP-----GLNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPK-ALG 2135
            .|. ..:|.....|     |:..::: |:..:....|..|.    |:.|:...:.:..||: .|.
  Rat   133 SHRCLTQFLEDEFPNLPTEGIESLVN-FLTGEAVVCHVASN----LAVEQLTLSAEFPVPQPVLR 192

  Fly  2136 DVFESIAGAI---------------FLDSNMS---LDVVWHVYSNM--MSPEIEQFSNSVPKSPI 2180
            ..|.::.||:               ||.:.|:   |..:|.:.:.|  :..|:::.:.|.|:|.:
  Rat   193 RTFFAVIGALLQSSGPERAALFIRDFLITQMTGKELFEMWTIVNPMGLLVEELKKRNISAPESRL 257

  Fly  2181 RELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTF--RGIGRNYRIAKCTAAKCALRQL 2239
                     |.:.|....|.     ...|.::|....  .|.|....:|:..||:.|||:|
  Rat   258 ---------TRQSGSTTALP-----LYFVGLYCDKRLIAEGPGETVLVAEEEAARVALRKL 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333
		RIBOc	2008..2172	CDD:238333	41/210 (20%)
		DSRM_DICER	2177..2240	CDD:380680	15/65 (23%)
Mrpl44	NP_001026820.1	DSRM	236..304	CDD:294045	18/81 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900