DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and Dicer1

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	XP_008763126.1	Gene:	Dicer1 / 299284	RGDID:	1309381	Length:	1918	Species:	Rattus norvegicus

Alignment Length:	2416	Identity:	771/2416 - (31%)
Similarity:	1099/2416 - (45%)	Gaps:	718/2416 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR----RHGRVS 65
            |....:|..::|||.:|||||..|.:.|||:||...|.|.|||:.|.:||:.:.|    .|.:.:
  Rat    32 WQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLSPHAKRT 96

  Fly    66 VYLSCEVGTSTEPC-SIYTMLTHLTDLRV----------------WQEQPDMQIPFDHCWTDYHV 113
            |:|   |.::.:.. .:..:.|| :||:|                |.::          :|.:.|
  Rat    97 VFL---VNSANQVAQQVSAVRTH-SDLKVGEYSNLEVNASWTKERWSQE----------FTKHQV 147

  Fly   114 SILRPEGFLYLLETRELLLSSVELIVLEDCHDSAV---YQRIRPLFENHIMPAPPADRPRILGLA 175
            .|:.....|.:|:...|.||.:.|:|.::||.:.:   |:.|..|.::    .|..  ||||||.
  Rat   148 LIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCDS----CPSC--PRILGLT 206

  Fly   176 GPLHSAGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLAD 240
            ..:.:..|:..:|...:..||:.:....|||:|:|.:.||.|:|.|.:|.|.||
  Rat   207 ASILNGKCDPDELEEKIQKLEKILKSGAETATDLVVLDRYTSQPCEIVVDCGPF----------- 260

  Fly   241 VLNTHKSFLLDHRYDPYE--IYGTDQFMDELKDI--------PDPKVDPLNVINSLLVVLHEMGP 295
               |.:|.|       ||  :...::.:|.:.|.        .|..:....:::....||..:||
  Rat   261 ---TDRSGL-------YERLLMELEEALDFINDCNVSVHSKERDSTLISKQILSDCRAVLVVLGP 315

  Fly   296 WCTQRAAHHFYQCNEKLKVKTPHE-----RHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQ 355
            ||..:.|....:   :|:....||     |.:||:  ..|.|.::::|||..|         |..
  Rat   316 WCADKVAGMMVR---ELQKYIKHEQEELHRKFLLF--TDTLLRKIHALCEEYF---------SPA 366

  Fly   356 TIE-RYSSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADF--NRLSHTLESKCRMVDQMD 417
            ::: :|.:|||.:||:.||.:||.|           |.|.:..::  ||......|.....|..|
  Rat   367 SLDLKYVTPKVMKLLEILRKYKPYE-----------RQQFESVEWYNNRNQDNYVSWSDSEDDDD 420

  Fly   418 QPPTETRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRH 482
            ....|.:             |..:||        .|:|.
  Rat   421 DEEIEEK-------------EKPETN--------FPSPF-------------------------- 438

  Fly   483 HRDHNDGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAEL 546
                   ::.||.:|:..:.:||.||..|:.|..::||:|.::...:.|.. :.......|:.|.
  Rat   439 -------TNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEA 496

  Fly   547 EHRRQEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHV 611
            |.|:|||||::||.|:.|:||.|||:|||:|:||||||||:|.||.||||||.||||||..:.:|
  Rat   497 EFRKQEEVLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYV 561

  Fly   612 ILVAPSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILN 676
            :|                               ||:|
  Rat   562 ML-------------------------------ADTD---------------------------- 567

  Fly   677 PEVFSKQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSL 741
                          |::..:::|..
  Rat   568 --------------KIKSFEEDLKT---------------------------------------- 578

  Fly   742 TEPEDTSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLA 806
                                            |:.||::|.:||:.:    .:.:||:..:....
  Rat   579 --------------------------------YKAIEKILRNKCSKS----VDGAEADVHAVVDD 607

  Fly   807 AYRPKPHLLT----GASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRL 867
            .....|::|.    |..|.:.:||..:|:||||||||.||.|..  :|...|....| |..||.|
  Rat   608 DDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAP--KCRTRELPDGT-FYSTLYL 669

  Fly   868 PINSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEP 932
            ||||||:..|||.||....||.|:.||..|.:||:|||||:.|.|:|||..:..|      ||:.
  Rat   670 PINSPLRASIVGPPMGCVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEE------ELDL 728

  Fly   933 EDEQIVQLSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRK 997
            .||:  :.|...|||:|||||.|.|.|.....:..|....|||||.|.:.|..|:|:|.|.|.||
  Rat   729 HDEE--ETSVPGRPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRK 791

  Fly   998 IYPPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTN 1062
            :|||||..:.|||||.|.||::..|.::||||||.:|:||.|....|:.:.:..:.....|.|::
  Rat   792 LYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELVTRLHQYIFSH 856

  Fly  1063 VLRLQKFLMLFDPDSTENCVFIVP-TVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQP- 1125
            :|||:|..:.|.|...|:...::| .|...:....||::|:|.|:.:...:  .:|..:...:.
  Rat   857 ILRLEKPALEFQPAGAESAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARI--GIPSTKYSKETP 919

  Fly  1126 --FDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTS 1188
              |..:.:||||::|.|||.|||..||||::...|:|||.||...|.||..||..||.|.:.|.:
  Rat   920 FVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLN 984

  Fly  1189 QPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWR 1253
            ||||||||||:|||.||||::|:||.|||.||.|.::||.|:|:.|||||||||.:||.||||||
  Rat   985 QPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWR 1049

  Fly  1254 TAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQK 1318
            .|||||.||||::.||.|:::|.|.::|.|:|.:.: ..||.:|.|||||      |||.:||..
  Rat  1050 KAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSL-PADFRYPNLDFGW------KKSIDSKSF 1107

  Fly  1319 ESLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIE-----------LIIEGEEKLQEA 1372
            .|    |.| ..||:.:.......|.:.:::......:.::|           |..|...|||
  Rat  1108 IS----TCN-SSLAESDNYCKHSTTVVPENAAHQGATRPSLENHDQMSVNCKRLPAESPAKLQ-- 1165

  Fly  1373 DDFIEIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFK 1437
                      ::::.|:.:.|                            |......::||.....
  Rat  1166 ----------SEVSVDLTAIN----------------------------GLSYNKSLANGSYDLV 1192

  Fly  1438 GPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDA 1502
            .....|..|....|.:.|.:||.:|                  |:..: :||.:
  Rat  1193 NRDFCQGNQLTYFKQEIPVQPTTSY------------------PIQNL-YNYEN----------- 1227

  Fly  1503 GRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRY 1567
                                          |.|.:||......|                    |
  Rat  1228 ------------------------------QPTPSNECPLLSNK--------------------Y 1242

  Fly  1568 EESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRR 1632
            .:..|...|                   ||.:.|...:.:||
  Rat  1243 LDGNANTST-------------------SDGSPAGSPRPAMM----------------------- 1265

  Fly  1633 ELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKA 1697
                                                                        |:.:|
  Rat  1266 ------------------------------------------------------------TAVEA 1270

  Fly  1698 ITSAILPAGFSFDRQPDLVGHP----GPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITT 1758
            :      .|.:...|...|||.    ||:|.:||||||:|||:||.||||||.:||||||:||||
  Rat  1271 L------EGRTDSEQSPSVGHSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITT 1329

  Fly  1759 YLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYV------- 1816
            ||:.||.:.|||:||::|||:|:|.||||||:::.|...|:.:.|:|..|||||.|.|
  Rat  1330 YLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKQGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNS 1394

  Fly  1817 -----------------------------------PK---ELEKALIE----------------- 1826
                                               ||   |.|..|:|
  Rat  1395 EKWEKDEMTKDCLLANGKLGEDCEEEEEEELAWRAPKEEAEYEDDLLEYDQEHIQFIDSMLMGSG 1459

  Fly  1827 ---AKIP---------THHWKL------------ADLLDIKNLSSVQIC-----EMVREKADALG 1862
               .|||         .:.||:            :||.|....|...:|     :.|.|....:|
  Rat  1460 AFVKKIPLSPFSTSDSAYEWKMPKKASLGSVPFSSDLEDFDYSSWDAMCYLDPSKAVEEDDFVVG 1524

  Fly  1863 L----EQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGA 1923
            .    |:|.|...|:..            |.|:|.::..|.|||||||||||:|.||..||.|.|
  Rat  1525 FWNPSEENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAA 1577

  Fly  1924 LLFMAWLGVRVLPITRQL----------DGGNQEQRIPG-------STKPNAENVVTVYGAWPTP 1971
            .||:..||::|||:.::.          :..:.:|:.|.       |.:.:|...:. ||....|
  Rat  1578 QLFLCSLGLKVLPVIKRTSRDKASYPAQENSSSQQKSPSGSCAAAVSPRSSAGKDLE-YGCLKIP 1641

  Fly  1972 RSPLLHF-APNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLG 2035
              |...| .|:|.:.|:.|:||||.||:.:.|.|::::|||||.|||||..|.:|||||||||||
  Rat  1642 --PRCMFDHPDAEKTLNHLISGFENFEKKINYIFKNKAYLLQAFTHASYHYNTITDCYQRLEFLG 1704

  Fly  2036 DAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFV 2100
            ||:||||||:||||||||||||.|||||||||||||||||||::.:||:|:.:||.|..|||.||
  Rat  1705 DAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFV 1769

  Fly  2101 RIQQENGHCISEEYYL-LSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMM 2164
            :.|.|.......:..| .|||:.:..||:|||||:||:|||:||||::||.|||:|||.||..||
  Rat  1770 QFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYPMM 1834

  Fly  2165 SPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRIAKC 2229
            .|.||:||.:||:||:|||||:|||||||...|:..|| :|||||:|..||.|:|:||:|||||.
  Rat  1835 RPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRIAKS 1898

  Fly  2230 TAAKCALRQLK 2240
            .||:.|||.||
  Rat  1899 AAARRALRSLK 1909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690	62/216 (29%)
		Dicer_PBD	240..344	CDD:277191	26/118 (22%)
		DEAD-like_helicase_C	490..614	CDD:365791	59/124 (48%)
		Dicer_dimer	825..916	CDD:397444	48/90 (53%)
		PAZ_dicer_like	1091..1212	CDD:239209	55/123 (45%)
		RIBOc	1724..1930	CDD:238333	105/300 (35%)
		RIBOc	2008..2172	CDD:238333	109/164 (66%)
		DSRM_DICER	2177..2240	CDD:380680	39/62 (63%)
Dicer1	XP_008763126.1	DEXHc_dicer	42..239	CDD:350792	62/216 (29%)
		Dicer_PBD	271..365	CDD:277191	22/107 (21%)
		SF2_C_dicer	372..564	CDD:350189	84/287 (29%)
		Dicer_dimer	630..718	CDD:397444	48/90 (53%)
		PAZ_dicer_like	886..1008	CDD:239209	55/123 (45%)
		RIBOc	1296..>1387	CDD:197778	57/90 (63%)
		RIBOc	1678..1842	CDD:238333	109/163 (67%)
		DSRM_DICER	1847..1909	CDD:380680	39/62 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353786
Domainoid	1	1.000	186	1.000	Domainoid score	I3287
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13251
Inparanoid	1	1.050	1177	1.000	Inparanoid score	I187
OMA	1	1.010	-	-		QHG57860
OrthoDB	1	1.010	-	-		D126291at33208
OrthoFinder	1	1.000	-	-		FOG0002051
OrthoInspector	1	1.000	-	-		oto95619
orthoMCL	1	0.900	-	-		OOG6_101152
Panther	1	1.100	-	-	LDO	PTHR14950
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1728
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860