DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-1 and DROSHA

DIOPT Version :9

Sequence 1:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster
Sequence 2:NP_001369437.1 Gene:DROSHA / 29102 HGNCID:17904 Length:1374 Species:Homo sapiens


Alignment Length:1350 Identity:259/1350 - (19%)
Similarity:431/1350 - (31%) Gaps:510/1350 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1109 GNTMPRAVPDEERQAQPFDPQRFQDAVVMPWYRNQDQPQY-----FYVAEICPHLSPLSC---FP 1165
            |.|..|....|..:.:..:..|.:|....|......:.:|     .|...:.|  .|..|   .|
Human   272 GRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVP--EPAGCTPELP 334

  Fly  1166 GDNYRTFKHYYLVKYGLTIQNT---SQPLLDVDHTSARLNFLTPRYVNRKGVALPTSS------- 1220
            |:               .|:||   :.||..|:|.|........|:...|.......|       
Human   335 GE---------------IIKNTDSWAPPLEIVNHRSPSREKKRARWEEEKDRWSDNQSSGKDKNY 384

  Fly  1221 --------EETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPCILYRINGLLLADDIRKQ 1277
                    |||...|.|. |::::|.|           :|  ..|.....|      .:.|...|
Human   385 TSIKEKEPEETMPDKNEE-EEEELLKP-----------VW--IRCTHSENY------YSSDPMDQ 429

  Fly  1278 VSADLGLGRQQIED--EDFEWPMLDFG------------W-----SLSEVLKKSRESKQKESLKD 1323
            |.....:|..::.|  :.||   .:.|            |     .|.|.|:.|.|| :.||.:|
Human   430 VGDSTVVGTSRLRDLYDKFE---EELGSRQEKAKAARPPWEPPKTKLDEDLESSSES-ECESDED 490

  Fly  1324 DTINGKD-------LADVEKK---PTSEETQL---DKDSKDD--------KVEKSAI-ELIIEGE 1366
            .|.:...       :|::::|   |.....:|   |....:|        |..::.| ..|..||
Human   491 STCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGE 555

  Fly  1367 EKLQEADDF-----------IEIGTWSNDMADDIASFNQEDDDEDDAF-------HLP------- 1406
            |.::.....           |.:...:|.:.|.....  |.||.:..|       |.|       
Human   556 EAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVI--EYDDHEYIFEGFSMFAHAPLTNIPLC 618

  Fly  1407 ----------------VLPANVKFCDQQTRYGSPTF-------------WDVSNGESGFKGPKSS 1442
                            ::|.|  ||.:    |...|             |::       |||...
Human   619 KVIRFNIDYTIHFIEEMMPEN--FCVK----GLELFSLFLFRDILELYDWNL-------KGPLFE 670

  Fly  1443 QNKQGGKGKAKGPAKPTFNYY--------DSDNSLGSSYD--------------DDDNAGPLNYM 1485
            .:.         |..|.|::.        |....:.|.:.              :::.|..|.:.
Human   671 DSP---------PCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWE 726

  Fly  1486 HHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLI 1550
            ...:....::.     .|.|......:..::...| :::.|....:|            |..:::
Human   727 ELEWQKYAEEC-----KGMIVTNPGTKPSSVRIDQ-LDREQFNPDVI------------TFPIIV 773

  Fly  1551 GFNFKHEDQKEPATIRYE---------ESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKV 1606
            .|..:      ||.:.|.         :|..||:..:.:...:...|:|.:.:|.:|.:....|.
Human   774 HFGIR------PAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKN 832

  Fly  1607 SM-----MELLKQ----------------LLPYVNEDV--------LAKKLG----DRRELLLSD 1638
            :|     :||..|                :||.:...:        |.|.:|    ||      .
Human   833 TMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDR------C 891

  Fly  1639 LVELNADWVARH-------EQETYNVMGCGDSFDNYNDH--HRLNLDEKQLKLQYERIEIEPPTS 1694
            |::|.....:.|       :....::..||.....|.|.  |.:::.:|.:.....         
Human   892 LLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLIN--------- 947

  Fly  1695 TKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTY 1759
               |.|.:              |...|:||.|       |.|     ||||.:||:.:::..:.:
Human   948 ---IMSRL--------------GQDDPTPSRI-------NHN-----ERLEFLGDAVVEFLTSVH 983

  Fly  1760 LYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKAL 1824
            ||..:.::.||.|:..|:..|.|.:|           .|:|.|.               ||::.:
Human   984 LYYLFPSLEEGGLATYRTAIVQNQHL-----------AMLAKKL---------------ELDRFM 1022

  Fly  1825 IEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIP 1889
            :.|..|                                                |.|.:...   
Human  1023 LYAHGP------------------------------------------------DLCRESDL--- 1036

  Fly  1890 YNLVSQHSIPDKSIADCVEALIGAYLIECGPR------GALLF------MAWLGVRVLPITRQLD 1942
                 :|     ::|:|.||||||..:|....      |.|||      ..||...:.|:..|  
Human  1037 -----RH-----AMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQ-- 1089

  Fly  1943 GGNQEQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDR 2007
                        :||.:.             .|:..:|        :|....||||::|..|...
Human  1090 ------------EPNTDR-------------QLIETSP--------VLQKLTEFEEAIGVIFTHV 1121

  Fly  2008 SYLLQAMTHASYTPNRLTDCY-QRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTI 2071
            ..|.:|.|..:...|.||..: ||:|||||:::..:.|.:|:.....|..|.||.|||:||||..
Human  1122 RLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRT 1186

  Fly  2072 FASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGD 2136
            .|.:|...|..::     ...||...|.|.::                           .|.|.|
Human  1187 QAKVAEELGMQEY-----AITNDKTKRPVALR---------------------------TKTLAD 1219

  Fly  2137 VFESIAGAIFLDSNMSLDVVWHVYSNM-MSPEIEQF----SNSVPKSPIRE-LLEL-----EPET 2190
            :.||...|:::|.:  |:.| |.:.|: ..|.:::|    ..:.|||.::: .|.|     ||:.
Human  1220 LLESFIAALYIDKD--LEYV-HTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDI 1281

  Fly  2191 AKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRI--AKCTAAKCALRQ 2238
            ..:...:.:........||.|:.||...|.|:...|  |:..||..||.:
Human  1282 PLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEK 1331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690
Dicer_PBD 240..344 CDD:277191
DEAD-like_helicase_C 490..614 CDD:365791
Dicer_dimer 825..916 CDD:397444
PAZ_dicer_like 1091..1212 CDD:239209 23/113 (20%)
RIBOc 1724..1930 CDD:238333 42/217 (19%)
RIBOc 2008..2172 CDD:238333 46/169 (27%)
DSRM_DICER 2177..2240 CDD:380680 19/69 (28%)
DROSHANP_001369437.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..95
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..406 31/151 (21%)
U2AF_lg 217..>317 CDD:273727 8/44 (18%)
Necessary for interaction with DGCR8 and pri-miRNA processing activity. /evidence=ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718 390..1365 234/1214 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 452..497 12/45 (27%)
RIBOc 959..1079 CDD:238333 43/218 (20%)
rnc 1105..1333 CDD:234633 72/261 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.