Protein Alignment Dcr-1 and dcr1

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: NP_588215.2
• Gene: dcr1 / 2538930
• PomBaseID: SPCC188.13C
• Length: 1374
• Species: Schizosaccharomyces pombe
• Alignment Length: 2296
• Identity: 373/2296 - (16%)
• Similarity: 630/2296 - (27%)
• Gaps: 1086/2296 - (47%)

  Fly    18 RDFQVELLATAYERNTIICLGHRSSKEFIALKLLQE-------LSRRARRHGRVSVY-------- 67
            |.:|.::...|.::||::.:...:.|..:|:||:::       :......|.::||:
pombe    13 RKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIKQKLEEQILIQESNLEHKKISVFLVNKVPLV 77

  Fly    68 ----------LSCEVGTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEGFL 122
                      |..:||......||......||::.:                .|:|.::..:.|.
pombe    78 FQQAEYIRSQLPAKVGMFYGELSIEMSEQLLTNIIL----------------KYNVIVITADLFY 126

  Fly   123 YLLETRELLLSSVELIVLEDCHDSA---VYQRIRPLFENH---IMPAPPADRPRILGLAGPLHSA 181
            ..|....|.::.:.||:.::||.:.   .|.||...|.:.   ::.......|||.|:
pombe   127 LFLARGFLSINDLNLIIFDECHHAIGNDAYARIMNDFYHRAKAVLSKKHFTLPRIFGM------- 184

  Fly   182 GCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHK 246
                                   |||                    ||              |.|
pombe   185 -----------------------TAS--------------------PF--------------TGK 192

  Fly   247 SFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAHHFYQCNEK 311
            ...|.||     :|..:|..|                                 :..|....||.
pombe   193 KGNLYHR-----LYQWEQLFD---------------------------------SKAHVVSENEL 219

  Fly   312 LKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRLLQTLRCFK 376
            .......|..|::|                           |.:.:...|...:::..:||:
pombe   220 ADYFCLPEESYVMY---------------------------SNKLVVPPSDSIIKKCEETLQ--- 254

  Fly   377 PEEVHTQADGLRRMRHQVDQADFNRLSHTLESK--------CRMVDQMDQPPTETRAL------- 426
                     |.:.:...|..|    |:.|::..        ..:||.::....:.:||
pombe   255 ---------GCKLISRAVKTA----LAETIDMGLWFGEQVWLYLVDFVETKRLKKKALGKQLSDD 306

  Fly   427 -VATLEQILHTTEDRQTNR---SAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHN 487
             ...::::....||.:.|:   :..|: |.........|........:...|:
pombe   307 EELAIDRLKIFVEDWKNNKYSDNGPRI-PVFDSTDVTDKVFKLLELLKATYRK------------ 358

  Fly   488 DGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQE 552
              ||::..:|:..:..||..|...:..::.  |:::      ....:....::..|..:..|||:
pombe   359 --SDSVRTVIFVERKATAFTLSLFMKTLNL--PNIR------AHSFIGHGPSDQGEFSMTFRRQK 413

  Fly   553 EVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPS 617
            :.|.:|:....||||.|:|.|||||||.||||:|::...|...|||.:|||||..:..:|.:
pombe   414 DTLHKFKTGKYNVLIATAVAEEGIDVPSCNLVIRFNICRTVTQYVQSRGRARAMASKFLIFL--- 475

  Fly   618 YKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSK 682
                                                                .|.::|..|..
pombe   476 ----------------------------------------------------NTEELLIHERI-- 486

  Fly   683 QPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDT 747
                     |.|.::...|.::|..||..|..|                    ||     |.|..
pombe   487 ---------LHEEKNLKFALSELSNSNIFDSLV--------------------CE-----ERERV 517

  Fly   748 SDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKP 812
            :|                |:|:::.:
pombe   518 TD----------------DIVYEVGE--------------------------------------- 527

  Fly   813 HLLTGASVDLGSAIALVNKYCARLPSDTFTK----LTAL-----WRCTRNERAGVTLFQYTLRLP 868
               |||.:....|::|:..:|..|..|.:|:    .||.     |.|          |:..|...
pombe   528 ---TGALLTGLYAVSLLYNFCNTLSRDVYTRYYPTFTAQPCLSGWYC----------FEVELPKA 579

  Fly   869 INSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPE 933
            ...|...   |.|..:...|::.||...|::|.|:|.:|..|:|:   .||....|.|..|   |
pombe   580 CKVPAAQ---GSPAKSIRKAKQNAAFIMCLDLIRMGLIDKHLKPL---DFRRKIADLETLE---E 635

  Fly   934 DEQIVQLSDEPRPGTTKRRQYY----YKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTR 994
            ||    |.||   |..:..:.|    :.::..:...|           |:.|     :..:.|..
pombe   636 DE----LKDE---GYIETYERYVPKSWMKVPEDITRC-----------FVSL-----LYTDANEG 677

  Fly   995 GRKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSG-EVKVSLELAKERVILTSEQIVCINGFLNY 1058
            ...|:.|      ...:.....||:.:|.:.:..| .||:.||..:
pombe   678 DNHIFHP------LVFVQAHSFPKIDSFILNSTVGPRVKIVLETIE------------------- 717

  Fly  1059 TFTNVLRLQKFLMLFDPDSTENCVFIVPTVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQA 1123
                             ||.:                 ||...|||::.:..
pombe   718 -----------------DSFK-----------------IDSHLLELLKKSTR------------- 735

  Fly  1124 QPFDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTS 1188
                                                                ||:::||:
pombe   736 ----------------------------------------------------YLLQFGLS----- 743

  Fly  1189 QPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWR 1253
                                                    .:|||:            .|...|.
pombe   744 ----------------------------------------TSLEQQ------------IPTPYWL 756

  Fly  1254 TAVCLPCILYR-INGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQ 1317
            ..:.|.|..|| :..|:..|.|:                ..|:.|
pombe   757 APLNLSCTDYRFLENLIDVDTIQ----------------NFFKLP-------------------- 785

  Fly  1318 KESLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWS 1382
                               :|....|.|..|:
pombe   786 -------------------EPVQNVTDLQSDT--------------------------------- 798

  Fly  1383 NDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQG 1447
                                         |...:.|:.|....|....|.|  |..|...::|..
pombe   799 -----------------------------VLLVNPQSIYEQYAFEGFVNSE--FMIPAKKKDKAP 832

  Fly  1448 GKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNE 1512
            .....|.|.:                        |||....                      |.
pombe   833 SALCKKLPLR------------------------LNYSLWG----------------------NR 851

  Fly  1513 AETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTE 1577
            |::|..:|:|.                             :|...|.          .|..:...
pombe   852 AKSIPKSQQVR-----------------------------SFYINDL----------YILPVSRH 877

  Fly  1578 IESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVEL 1642
            :::..:|:|                    |::..::.||
pombe   878 LKNSALLIP--------------------SILYHIENLL-------------------------- 896

  Fly  1643 NADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGF 1707
                             ...||                 :::.|::.:..|:.:|:|||.....|
pombe   897 -----------------VASSF-----------------IEHFRLDCKIDTACQALTSAESQLNF 927

  Fly  1708 SFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKL 1772
            .:|                                |||..||.|||...:..:::.:.:..|.:|
pombe   928 DYD--------------------------------RLEFYGDCFLKLGASITVFLKFPDTQEYQL 960

  Fly  1773 SHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLA 1837
            ...|.|.::|.|||::.....|.:|.::|..|                          ..||
pombe   961 HFNRKKIISNCNLYKVAIDCELPKYALSTPLE--------------------------IRHW--- 996

  Fly  1838 DLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKS 1902
                         |....:|:                  ::|.|.       |.::.:.|:  |.
pombe   997 -------------CPYGFQKS------------------TSDKCR-------YAVLQKLSV--KR 1021

  Fly  1903 IADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGA 1967
            |||.|||.|||.|::.|...||.....|.|.:|.|:...:..|....  .:...:..||...|.:
pombe  1022 IADMVEASIGACLLDSGLDSALKICKSLSVGLLDISNWDEWNNYFDL--NTYADSLRNVQFPYSS 1084

  Fly  1968 WPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNR-LTDCYQRL 2031
            :                           .||::||.|:::..|..|..|.|....: :.:.||:|
pombe  1085 Y---------------------------IEETIGYSFKNKKLLHLAFIHPSMMSQQGIYENYQQL 1122

  Fly  2032 EFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVI 2096
            ||||||||||:|.::||:.....:.|.|||.:|..|.|...:.:......||:.:|.|..:.|.|
pombe  1123 EFLGDAVLDYIIVQYLYKKYPNATSGELTDYKSFYVCNKSLSYIGFVLNLHKYIQHESAAMCDAI 1187

  Fly  2097 DRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSL-------- 2153
            ..:..:.:......||..:...|        ::.||.:.|..|::..||||||..||
pombe  1188 FEYQELIEAFRETASENPWFWFE--------IDSPKFISDTLEAMICAIFLDSGFSLQSLQFVLP 1244

  Fly  2154 ----------------DVVWHVYSNMMSPEIEQFSNSV----PKSPIRELLELEPETAK------ 2192
                            |:...||..:.....|.|....    .||..:.||..|....|
pombe  1245 LFLNSLGDATHTKAKGDIEHKVYQLLKDQGCEDFGTKCVIEEVKSSHKTLLNTELHLTKYYGFSF 1309

  Fly  2193 --------FGKPEKLADGRRV 2205
                    :||..|:|:.:.:
pombe  1310 FRHGNIVAYGKSRKVANAKYI 1330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	38/220 (17%)
		Dicer_PBD	240..344	CDD:277191	14/103 (14%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	41/123 (33%)
		Dicer_dimer	825..916	CDD:460900	25/99 (25%)
		PAZ_dicer_like	1091..1212	CDD:239209	9/120 (8%)
		RIBOc	1724..1930	CDD:238333	42/205 (20%)
		RIBOc	2008..2172	CDD:238333	52/188 (28%)
		DSRM_DICER	2177..2240	CDD:380680	10/43 (23%)
dcr1	NP_588215.2	DEXHc_dicer	12..215	CDD:350792	50/319 (16%)
		SF2_C_dicer	344..475	CDD:350189	43/152 (28%)
		Dicer_dimer	537..625	CDD:460900	26/103 (25%)
		RIBOc	912..1045	CDD:197778	49/233 (21%)
		RIBOc	1098..1247	CDD:238333	48/156 (31%)