DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-1 and dcr1

DIOPT Version :9

Sequence 1:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster
Sequence 2:NP_588215.2 Gene:dcr1 / 2538930 PomBaseID:SPCC188.13c Length:1374 Species:Schizosaccharomyces pombe


Alignment Length:2296 Identity:373/2296 - (16%)
Similarity:630/2296 - (27%) Gaps:1086/2296 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 RDFQVELLATAYERNTIICLGHRSSKEFIALKLLQE-------LSRRARRHGRVSVY-------- 67
            |.:|.::...|.::||::.:...:.|..:|:||:::       :......|.::||:        
pombe    13 RKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIKQKLEEQILIQESNLEHKKISVFLVNKVPLV 77

  Fly    68 ----------LSCEVGTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEGFL 122
                      |..:||......||......||::.:                .|:|.::..:.|.
pombe    78 FQQAEYIRSQLPAKVGMFYGELSIEMSEQLLTNIIL----------------KYNVIVITADLFY 126

  Fly   123 YLLETRELLLSSVELIVLEDCHDSA---VYQRIRPLFENH---IMPAPPADRPRILGLAGPLHSA 181
            ..|....|.::.:.||:.::||.:.   .|.||...|.:.   ::.......|||.|:       
pombe   127 LFLARGFLSINDLNLIIFDECHHAIGNDAYARIMNDFYHRAKAVLSKKHFTLPRIFGM------- 184

  Fly   182 GCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHK 246
                                   |||                    ||              |.|
pombe   185 -----------------------TAS--------------------PF--------------TGK 192

  Fly   247 SFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAHHFYQCNEK 311
            ...|.||     :|..:|..|                                 :..|....||.
pombe   193 KGNLYHR-----LYQWEQLFD---------------------------------SKAHVVSENEL 219

  Fly   312 LKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRLLQTLRCFK 376
            .......|..|::|                           |.:.:...|...:::..:||:   
pombe   220 ADYFCLPEESYVMY---------------------------SNKLVVPPSDSIIKKCEETLQ--- 254

  Fly   377 PEEVHTQADGLRRMRHQVDQADFNRLSHTLESK--------CRMVDQMDQPPTETRAL------- 426
                     |.:.:...|..|    |:.|::..        ..:||.::....:.:||       
pombe   255 ---------GCKLISRAVKTA----LAETIDMGLWFGEQVWLYLVDFVETKRLKKKALGKQLSDD 306

  Fly   427 -VATLEQILHTTEDRQTNR---SAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHN 487
             ...::::....||.:.|:   :..|: |.........|........:...|:            
pombe   307 EELAIDRLKIFVEDWKNNKYSDNGPRI-PVFDSTDVTDKVFKLLELLKATYRK------------ 358

  Fly   488 DGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQE 552
              ||::..:|:..:..||..|...:..::.  |:::      ....:....::..|..:..|||:
pombe   359 --SDSVRTVIFVERKATAFTLSLFMKTLNL--PNIR------AHSFIGHGPSDQGEFSMTFRRQK 413

  Fly   553 EVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPS 617
            :.|.:|:....||||.|:|.|||||||.||||:|::...|...|||.:|||||..:..:|.:   
pombe   414 DTLHKFKTGKYNVLIATAVAEEGIDVPSCNLVIRFNICRTVTQYVQSRGRARAMASKFLIFL--- 475

  Fly   618 YKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSK 682
                                                                .|.::|..|..  
pombe   476 ----------------------------------------------------NTEELLIHERI-- 486

  Fly   683 QPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDT 747
                     |.|.::...|.::|..||..|..|                    ||     |.|..
pombe   487 ---------LHEEKNLKFALSELSNSNIFDSLV--------------------CE-----ERERV 517

  Fly   748 SDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKP 812
            :|                |:|:::.:                                       
pombe   518 TD----------------DIVYEVGE--------------------------------------- 527

  Fly   813 HLLTGASVDLGSAIALVNKYCARLPSDTFTK----LTAL-----WRCTRNERAGVTLFQYTLRLP 868
               |||.:....|::|:..:|..|..|.:|:    .||.     |.|          |:..|...
pombe   528 ---TGALLTGLYAVSLLYNFCNTLSRDVYTRYYPTFTAQPCLSGWYC----------FEVELPKA 579

  Fly   869 INSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPE 933
            ...|...   |.|..:...|::.||...|::|.|:|.:|..|:|:   .||....|.|..|   |
pombe   580 CKVPAAQ---GSPAKSIRKAKQNAAFIMCLDLIRMGLIDKHLKPL---DFRRKIADLETLE---E 635

  Fly   934 DEQIVQLSDEPRPGTTKRRQYY----YKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTR 994
            ||    |.||   |..:..:.|    :.::..:...|           |:.|     :..:.|..
pombe   636 DE----LKDE---GYIETYERYVPKSWMKVPEDITRC-----------FVSL-----LYTDANEG 677

  Fly   995 GRKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSG-EVKVSLELAKERVILTSEQIVCINGFLNY 1058
            ...|:.|      ...:.....||:.:|.:.:..| .||:.||..:                   
pombe   678 DNHIFHP------LVFVQAHSFPKIDSFILNSTVGPRVKIVLETIE------------------- 717

  Fly  1059 TFTNVLRLQKFLMLFDPDSTENCVFIVPTVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQA 1123
                             ||.:                 ||...|||::.:..             
pombe   718 -----------------DSFK-----------------IDSHLLELLKKSTR------------- 735

  Fly  1124 QPFDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTS 1188
                                                                ||:::||:     
pombe   736 ----------------------------------------------------YLLQFGLS----- 743

  Fly  1189 QPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWR 1253
                                                    .:|||:            .|...|.
pombe   744 ----------------------------------------TSLEQQ------------IPTPYWL 756

  Fly  1254 TAVCLPCILYR-INGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQ 1317
            ..:.|.|..|| :..|:..|.|:                ..|:.|                    
pombe   757 APLNLSCTDYRFLENLIDVDTIQ----------------NFFKLP-------------------- 785

  Fly  1318 KESLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWS 1382
                               :|....|.|..|:                                 
pombe   786 -------------------EPVQNVTDLQSDT--------------------------------- 798

  Fly  1383 NDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQG 1447
                                         |...:.|:.|....|....|.|  |..|...::|..
pombe   799 -----------------------------VLLVNPQSIYEQYAFEGFVNSE--FMIPAKKKDKAP 832

  Fly  1448 GKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNE 1512
            .....|.|.:                        |||....                      |.
pombe   833 SALCKKLPLR------------------------LNYSLWG----------------------NR 851

  Fly  1513 AETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTE 1577
            |::|..:|:|.                             :|...|.          .|..:...
pombe   852 AKSIPKSQQVR-----------------------------SFYINDL----------YILPVSRH 877

  Fly  1578 IESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVEL 1642
            :::..:|:|                    |::..::.||                          
pombe   878 LKNSALLIP--------------------SILYHIENLL-------------------------- 896

  Fly  1643 NADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGF 1707
                             ...||                 :::.|::.:..|:.:|:|||.....|
pombe   897 -----------------VASSF-----------------IEHFRLDCKIDTACQALTSAESQLNF 927

  Fly  1708 SFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKL 1772
            .:|                                |||..||.|||...:..:::.:.:..|.:|
pombe   928 DYD--------------------------------RLEFYGDCFLKLGASITVFLKFPDTQEYQL 960

  Fly  1773 SHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLA 1837
            ...|.|.::|.|||::.....|.:|.::|..|                          ..||   
pombe   961 HFNRKKIISNCNLYKVAIDCELPKYALSTPLE--------------------------IRHW--- 996

  Fly  1838 DLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKS 1902
                         |....:|:                  ::|.|.       |.::.:.|:  |.
pombe   997 -------------CPYGFQKS------------------TSDKCR-------YAVLQKLSV--KR 1021

  Fly  1903 IADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGA 1967
            |||.|||.|||.|::.|...||.....|.|.:|.|:...:..|....  .:...:..||...|.:
pombe  1022 IADMVEASIGACLLDSGLDSALKICKSLSVGLLDISNWDEWNNYFDL--NTYADSLRNVQFPYSS 1084

  Fly  1968 WPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNR-LTDCYQRL 2031
            :                           .||::||.|:::..|..|..|.|....: :.:.||:|
pombe  1085 Y---------------------------IEETIGYSFKNKKLLHLAFIHPSMMSQQGIYENYQQL 1122

  Fly  2032 EFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVI 2096
            ||||||||||:|.::||:.....:.|.|||.:|..|.|...:.:......||:.:|.|..:.|.|
pombe  1123 EFLGDAVLDYIIVQYLYKKYPNATSGELTDYKSFYVCNKSLSYIGFVLNLHKYIQHESAAMCDAI 1187

  Fly  2097 DRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSL-------- 2153
            ..:..:.:......||..:...|        ::.||.:.|..|::..||||||..||        
pombe  1188 FEYQELIEAFRETASENPWFWFE--------IDSPKFISDTLEAMICAIFLDSGFSLQSLQFVLP 1244

  Fly  2154 ----------------DVVWHVYSNMMSPEIEQFSNSV----PKSPIRELLELEPETAK------ 2192
                            |:...||..:.....|.|....    .||..:.||..|....|      
pombe  1245 LFLNSLGDATHTKAKGDIEHKVYQLLKDQGCEDFGTKCVIEEVKSSHKTLLNTELHLTKYYGFSF 1309

  Fly  2193 --------FGKPEKLADGRRV 2205
                    :||..|:|:.:.:
pombe  1310 FRHGNIVAYGKSRKVANAKYI 1330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690 38/220 (17%)
Dicer_PBD 240..344 CDD:277191 14/103 (14%)
DEAD-like_helicase_C 490..614 CDD:365791 41/123 (33%)
Dicer_dimer 825..916 CDD:397444 25/99 (25%)
PAZ_dicer_like 1091..1212 CDD:239209 9/120 (8%)
RIBOc 1724..1930 CDD:238333 42/205 (20%)
RIBOc 2008..2172 CDD:238333 52/188 (28%)
DSRM_DICER 2177..2240 CDD:380680 10/43 (23%)
dcr1NP_588215.2 MPH1 1..501 CDD:224036 122/737 (17%)
DEXDc 26..188 CDD:238005 36/227 (16%)
Helicase_C 343..464 CDD:278689 38/142 (27%)
Dicer_dimer 538..620 CDD:281376 23/94 (24%)
RIBOc 912..1045 CDD:197778 49/233 (21%)
Rnc 1076..1345 CDD:223644 71/290 (24%)
RIBOc 1098..1247 CDD:238333 48/156 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 67 1.000 Domainoid score I2756
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H13251
Inparanoid 1 1.050 299 1.000 Inparanoid score I607
OMA 1 1.010 - - QHG57860
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - otm47000
orthoMCL 1 0.900 - - OOG6_101152
Panther 1 1.100 - - LDO PTHR14950
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R301
SonicParanoid 1 1.000 - - X1728
TreeFam 1 0.960 - -
1413.860

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