DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-1 and DICER1

DIOPT Version :9

Sequence 1:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster
Sequence 2:NP_001258211.1 Gene:DICER1 / 23405 HGNCID:17098 Length:1922 Species:Homo sapiens


Alignment Length:2423 Identity:768/2423 - (31%)
Similarity:1097/2423 - (45%) Gaps:728/2423 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR----RHGRVS 65
            |....:|..::|||.:|||||..|.:.|||:||...|.|.|||:.|.:|||.:.|    |:|:.:
Human    32 WQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRT 96

  Fly    66 VYLSCEVGTSTEPC-SIYTMLTHLTDLRV----------------WQEQPDMQIPFDHCWTDYHV 113
            |:|   |.::.:.. .:..:.|| :||:|                |.::          :|.:.|
Human    97 VFL---VNSANQVAQQVSAVRTH-SDLKVGEYSNLEVNASWTKERWNQE----------FTKHQV 147

  Fly   114 SILRPEGFLYLLETRELLLSSVELIVLEDCHDSAV---YQRIRPLFENHIMPAPPADRPRILGLA 175
            .|:.....|.:|:...|.||.:.|:|.::||.:.:   |:.|..|.||    .|..  ||||||.
Human   148 LIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCEN----CPSC--PRILGLT 206

  Fly   176 GPLHSAGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFE-----MDELS 235
            ..:.:..|:.::|...:..||:.:....|||:|:|.:.||.|:|.|.:|.|.||.     .:.|.
Human   207 ASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLL 271

  Fly   236 LVLADVLNTHKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQR 300
            :.|.:.||    |:.|..   ..::..::         |..:....:::....||..:||||..:
Human   272 MELEEALN----FINDCN---ISVHSKER---------DSTLISKQILSDCRAVLVVLGPWCADK 320

  Fly   301 AAHHFYQCNEKLKVKTPHE-----RHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIE-R 359
            .|....:   :|:....||     |.:||:  ..|.|.::::|||..|         |..::: :
Human   321 VAGMMVR---ELQKYIKHEQEELHRKFLLF--TDTFLRKIHALCEEHF---------SPASLDLK 371

  Fly   360 YSSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADF--NRLSHTLESKCRMVDQMDQPPTE 422
            :.:|||.:||:.||.:||.|           |.|.:..::  ||                     
Human   372 FVTPKVIKLLEILRKYKPYE-----------RQQFESVEWYNNR--------------------- 404

  Fly   423 TRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHN 487
                          .:|...:.|.:...........|.||.:  |...|.|              
Human   405 --------------NQDNYVSWSDSEDDDEDEEIEEKEKPET--NFPSPFT-------------- 439

  Fly   488 DGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAELEHRRQ 551
               :.||.:|:..:.:||.||..|:.|..::||:|.::...:.|.. :.......|:.|.|.|:|
Human   440 ---NILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQ 501

  Fly   552 EEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAP 616
            ||||::||.|:.|:||.||::|||:|:||||||||:|.||.||||||.||||||..:.:::|   
Human   502 EEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIML--- 563

  Fly   617 SYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFS 681
                                        ||:|                                 
Human   564 ----------------------------ADTD--------------------------------- 567

  Fly   682 KQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPED 746
                     |::..:::|..                                             
Human   568 ---------KIKSFEEDLKT--------------------------------------------- 578

  Fly   747 TSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTE-------PPEQEQSEAERFSAC 804
                                       |:.||::|.:||:.:.       .|..:..:..     
Human   579 ---------------------------YKAIEKILRNKCSKSVDTGETDIDPVMDDDDVF----- 611

  Fly   805 LAAYRPKPHLLT----GASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTL 865
                  .|::|.    |..|.:.:||..:|:||||||||.||.|..  :|...|....| |..||
Human   612 ------PPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAP--KCRTRELPDGT-FYSTL 667

  Fly   866 RLPINSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFEL 930
            .|||||||:..|||.||....||.|:.||..|.:||:||||||.|.|:|||..:..|      ||
Human   668 YLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEE------EL 726

  Fly   931 EPEDEQIVQLSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRG 995
            :..||:  :.|...|||:|||||.|.|.|.....|..|....|||||.|.:.|..|:|:|.|.|.
Human   727 DLHDEE--ETSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRR 789

  Fly   996 RKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTF 1060
            ||:|||||..:.|||||.|.||::..|.::||||||.:|:||.|...:|:.:.:..|.....|.|
Human   790 RKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIF 854

  Fly  1061 TNVLRLQKFLMLFDPDSTENCVFIVP-TVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQ 1124
            :::|||:|..:.|.|...::...::| .|...:....||::|:|.|:.:...:  .:|..:...:
Human   855 SHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARI--GIPSTKYTKE 917

  Fly  1125 P---FDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQN 1186
            .   |..:.:||||::|.|||.|||..||||::...|:|||.||...|.||..||..||.|.:.|
Human   918 TPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTN 982

  Fly  1187 TSQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASL 1251
            .:||||||||||:|||.||||::|:||.|||.||.|.::||.|:|:.|||||||||.:||.||||
Human   983 LNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASL 1047

  Fly  1252 WRTAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESK 1316
            ||.|||||.||||::.||.|:::|.|.::|.|:|.:.: ..||.:|.|||||      |||.:||
Human  1048 WRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSL-PADFRYPNLDFGW------KKSIDSK 1105

  Fly  1317 QKESL------------KDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKL 1369
            ...|:            |..||..::.|......||..      ...|::..:...|:.|...||
Human  1106 SFISISNSSSAENDNYCKHSTIVPENAAHQGANRTSSL------ENHDQMSVNCRTLLSESPGKL 1164

  Fly  1370 QEADDFIEIGTWSNDM-ADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGE 1433
            .     :|:   |.|: |.:..|:||                                 :::||.
Human  1165 H-----VEV---SADLTAINGLSYNQ---------------------------------NLANGS 1188

  Fly  1434 SGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVAD 1498
            .........|..|....|.:.|.:||.:|                                    
Human  1189 YDLANRDFCQGNQLNYYKQEIPVQPTTSY------------------------------------ 1217

  Fly  1499 DIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPA 1563
                                                         ..:||     :.:|:|.:|:
Human  1218 ---------------------------------------------SIQNL-----YSYENQPQPS 1232

  Fly  1564 TIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKL 1628
                                                                             
Human  1233 ----------------------------------------------------------------- 1232

  Fly  1629 GDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPT 1693
             |...||.:..::.||:...........||                                 |.
Human  1233 -DECTLLSNKYLDGNANKSTSDGSPVMAVM---------------------------------PG 1263

  Fly  1694 STKAITSAILPAGFSFDRQPDLVGHP----GPSPSIILQALTMSNANDGINLERLETIGDSFLKY 1754
            :|..|  .:|......::.|. :|:.    ||:|.:||||||:|||:||.||||||.:||||||:
Human  1264 TTDTI--QVLKGRMDSEQSPS-IGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKH 1325

  Fly  1755 AITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYV--- 1816
            ||||||:.||.:.|||:||::|||:|:|.||||||::|.|...|:.:.|:|..|||||.|.|   
Human  1326 AITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQD 1390

  Fly  1817 -----------------------------------------PKE---LEKALIE----------- 1826
                                                     |||   .|...:|           
Human  1391 KSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDN 1455

  Fly  1827 ---------AKI---------PTHHWKL------------ADLLDIKNLSSVQIC-----EMVRE 1856
                     .||         ..:.||:            :|..|....|...:|     :.|.|
Human  1456 MLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEE 1520

  Fly  1857 KADALGL----EQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIE 1917
            ....:|.    |:|.|...|:..            |.|:|.::..|.|||||||||||:|.||..
Human  1521 DDFVVGFWNPSEENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTS 1573

  Fly  1918 CGPRGALLFMAWLGVRVLPITRQLD----------GGNQEQR------IPGSTKPNAENVV--TV 1964
            ||.|.|.||:..||::|||:.::.|          ..|.:|:      ...|...:..:|:  :.
Human  1574 CGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDSE 1638

  Fly  1965 YGAWPTPRSPLLHF-APNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCY 2028
            ||....|  |...| .|:|.:.|:.|:||||.||:.:.|:|::::|||||.|||||..|.:||||
Human  1639 YGCLKIP--PRCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCY 1701

  Fly  2029 QRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLN 2093
            |||||||||:||||||:||||||||||||.|||||||||||||||||||::.:||:|:.:||.|.
Human  1702 QRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELF 1766

  Fly  2094 DVIDRFVRIQQENGHCISEEYYL-LSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVW 2157
            .|||.||:.|.|.......:..| .|||:.:..||:|||||:||:|||:||||::||.|||:.||
Human  1767 HVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVW 1831

  Fly  2158 HVYSNMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGR 2222
            .||..||.|.||:||.:||:||:|||||:|||||||...|:..|| :|||||:|..||.|:|:||
Human  1832 QVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGR 1895

  Fly  2223 NYRIAKCTAAKCALRQLK 2240
            :|||||..||:.|||.||
Human  1896 SYRIAKSAAARRALRSLK 1913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690 66/216 (31%)
Dicer_PBD 240..344 CDD:277191 23/108 (21%)
DEAD-like_helicase_C 490..614 CDD:365791 57/124 (46%)
Dicer_dimer 825..916 CDD:397444 49/90 (54%)
PAZ_dicer_like 1091..1212 CDD:239209 55/123 (45%)
RIBOc 1724..1930 CDD:238333 103/302 (34%)
RIBOc 2008..2172 CDD:238333 108/164 (66%)
DSRM_DICER 2177..2240 CDD:380680 39/62 (63%)
DICER1NP_001258211.1 DEXHc_dicer 42..239 CDD:350792 66/216 (31%)
DECH box 175..178 0/2 (0%)
Required for interaction with PRKRA and TARBP2 256..595 121/578 (21%)
Dicer_PBD 271..365 CDD:277191 25/123 (20%)
SF2_C_dicer 372..564 CDD:350189 80/287 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..433 4/25 (16%)
Dicer_dimer 630..718 CDD:397444 49/90 (54%)
PAZ_dicer_like 886..1008 CDD:239209 55/123 (45%)
RIBOc 1296..>1387 CDD:197778 58/90 (64%)
Rnc 1666..1918 CDD:223644 159/249 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159716
Domainoid 1 1.000 186 1.000 Domainoid score I3374
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H13251
Inparanoid 1 1.050 934 1.000 Inparanoid score I348
Isobase 1 0.950 - 0 Normalized mean entropy S5945
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D126291at33208
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - oto88480
orthoMCL 1 0.900 - - OOG6_101152
Panther 1 1.100 - - LDO PTHR14950
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R301
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.840

Return to query results.
Submit another query.