DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-1 and Dicer1

DIOPT Version :9

Sequence 1:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster
Sequence 2:NP_683750.2 Gene:Dicer1 / 192119 MGIID:2177178 Length:1906 Species:Mus musculus


Alignment Length:2419 Identity:778/2419 - (32%)
Similarity:1102/2419 - (45%) Gaps:726/2419 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR----RHGRVS 65
            |....:|..::|||.:|||||..|.:.|||:||...|.|.|||:.|.:||:.:.|    .|.:.:
Mouse    22 WQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHAKRT 86

  Fly    66 VYLSCEVGTSTEPC-SIYTMLTHLTDLRVWQEQPDMQIPFDHCW---------TDYHVSILRPEG 120
            |:|   |.::.:.. .:..:.|| :||:| .|..|:::  :..|         |.:.|.|:....
Mouse    87 VFL---VNSANQVAQQVSAVRTH-SDLKV-GEYSDLEV--NASWTKERWSQEFTKHQVLIMTCYV 144

  Fly   121 FLYLLETRELLLSSVELIVLEDCHDSAV---YQRIRPLFENHIMPAPPADRPRILGLAGPLHSAG 182
            .|.:|:...|.||.:.|:|.::||.:.:   |:.|..|.|:    .|..  ||||||...:.:..
Mouse   145 ALTVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCES----CPSC--PRILGLTASILNGK 203

  Fly   183 CELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHKS 247
            |:.::|...:..||:.:....|||:|:|.:.||.|:|.|.:|.|.||              |.:|
Mouse   204 CDPEELEEKIQKLERILRSDAETATDLVVLDRYTSQPCEIVVDCGPF--------------TDRS 254

  Fly   248 FLLDHRYDPYE--IYGTDQFMDELKDI--------PDPKVDPLNVINSLLVVLHEMGPWCTQRAA 302
            .|       ||  :...:..:|.:.|.        .|..:....:::....||..:||||..:.|
Mouse   255 GL-------YERLLMELEAALDFINDCNVAVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVA 312

  Fly   303 HHFYQCNEKLKVKTPHE-----RHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIE-RYS 361
            ....:   :|:....||     |.:||:  ..|.|.::::|||..|         |..::: :|.
Mouse   313 GMMVR---ELQKYIKHEQEELHRKFLLF--TDTLLRKIHALCEEYF---------SPASLDLKYV 363

  Fly   362 SPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADF--NRLSHTLESKCRMVDQMDQPPTETR 424
            :|||.:||:.||.:||.|           |.|.:..::  ||......|.....|..|....|.:
Mouse   364 TPKVMKLLEILRKYKPYE-----------RQQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEK 417

  Fly   425 ALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDG 489
                         |..:||        .|:|.                                 
Mouse   418 -------------EKPETN--------FPSPF--------------------------------- 428

  Fly   490 SDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAELEHRRQEE 553
            ::.||.:|:..:.:||.||..|:.|..::||:|.::...:.|.. :.......|:.|.|.|:|||
Mouse   429 TNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEAEFRKQEE 493

  Fly   554 VLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSY 618
            ||::||.|:.|:||.|||:|||:|:||||||||:|.||.||||||.||||||..:.:|:|     
Mouse   494 VLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVML----- 553

  Fly   619 KSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQ 683
                                      ||:|                                   
Mouse   554 --------------------------ADTD----------------------------------- 557

  Fly   684 PPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTS 748
                   |::..:::|..                                               
Mouse   558 -------KIKSFEEDLKT----------------------------------------------- 568

  Fly   749 DTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKPH 813
                                     |:.||::|.:||:.:    .:.:||:..:.........|:
Mouse   569 -------------------------YKAIEKILRNKCSKS----ADGAEADVHAGVDDEDAFPPY 604

  Fly   814 LLT----GASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLK 874
            :|.    |..|.:.:||..:|:||||||||.||.|..  :|...|....| |..||.|||||||:
Mouse   605 VLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAP--KCRTRELPDGT-FYSTLYLPINSPLR 666

  Fly   875 HDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQ 939
            ..|||.||.:..||.|:.||..|.:||:|||||:.|.|:|||..:..|      ||:..||:  :
Mouse   667 ASIVGPPMDSVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEE------ELDLHDEE--E 723

  Fly   940 LSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDA 1004
            .|...|||:|||||.|.|.|.....:..|....|||||.|.:.|..|:|:|.|.|.||:|||||.
Mouse   724 TSVPGRPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDT 788

  Fly  1005 QQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKF 1069
            .:.|||||.|.||::..|.::||||||.:|:||.|....|:.:.:..|.....|.|:::|||:|.
Mouse   789 TRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELITRLHQYIFSHILRLEKP 853

  Fly  1070 LMLFDPDSTENCVFIVP-TVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQP---FDPQR 1130
            .:.|.|...|:...::| .|...:|...||::|:|.|:.:...:  .:|..:...:.   |..:.
Mouse   854 ALEFKPTGAESAYCVLPLNVVNDSGTLDIDFKFMEDIEKSEARI--GIPSTKYSKETPFVFKLED 916

  Fly  1131 FQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVD 1195
            :||||::|.|||.|||..||||::...|:|||.||...|.||..||..||.|.:.|.:|||||||
Mouse   917 YQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVD 981

  Fly  1196 HTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPC 1260
            |||:|||.||||::|:||.|||.||.|.::||.|:|:.|||||||||.:||.||||||.|||||.
Mouse   982 HTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPS 1046

  Fly  1261 ILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQ-----KES 1320
            ||||::.||.|:::|.|.::|.|:|.:.: ..||.:|.|||||      |||.:||.     ..|
Mouse  1047 ILYRLHCLLTAEELRAQTASDAGVGVRSL-PVDFRYPNLDFGW------KKSIDSKSFISSCNSS 1104

  Fly  1321 LKDDTINGKDLADV---------EKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFI 1376
            |.:.....|....|         ..:|:.|        ..|::..:...|..|...|||      
Mouse  1105 LAESDNYCKHSTTVVPEHAAHQGATRPSLE--------NHDQMSVNCKRLPAESPAKLQ------ 1155

  Fly  1377 EIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKS 1441
                  ::::.|:.:.|                                         |.     
Mouse  1156 ------SEVSTDLTAIN-----------------------------------------GL----- 1168

  Fly  1442 SQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYD----DDDNAGPLNYMHHNYSSDDDDVADDIDA 1502
            |.||                     |....|||    |......|||.                 
Mouse  1169 SYNK---------------------NLANGSYDLVNRDFCQGNQLNYF----------------- 1195

  Fly  1503 GRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPA---- 1563
                                    ||...:|.|.:...|     ||     :.:|:|.:|:    
Mouse  1196 ------------------------KQEIPVQPTTSYPIQ-----NL-----YNYENQPKPSNECP 1226

  Fly  1564 --TIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAK 1626
              :..|.:..|...|                   ||.:.|.....:||..:|.|           
Mouse  1227 LLSNTYLDGNANTST-------------------SDGSPAVSTMPAMMNAVKAL----------- 1261

  Fly  1627 KLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEP 1691
                                                                     .:|::.| 
Mouse  1262 ---------------------------------------------------------KDRMDSE- 1268

  Fly  1692 PTSTKAITSAILPAGFSFDRQPDLVGHP----GPSPSIILQALTMSNANDGINLERLETIGDSFL 1752
                                |...||:.    ||:|.:||||||:|||:||.||||||.:|||||
Mouse  1269 --------------------QSPSVGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFL 1313

  Fly  1753 KYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYV- 1816
            |:||||||:.||.:.|||:||::|||:|:|.||||||::|.|...|:.:.|:|..|||||.|.| 
Mouse  1314 KHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVN 1378

  Fly  1817 ---------------------------------------PKE------------------LEKAL 1824
                                                   |||                  ::..|
Mouse  1379 QDKSNSEKWEKDEMTKDCLLANGKLGEACEEEEDLTWRAPKEEAEDEDDFLEYDQEHIQFIDSML 1443

  Fly  1825 I--------------EAKIPTHHWKL------------ADLLDIKNLSSVQIC-----EMVREKA 1858
            :              .|....:.||:            :.|.|....|...:|     :.|.|..
Mouse  1444 MGSGAFVRKISLSPFSASDSAYEWKMPKKASLGSMPFASGLEDFDYSSWDAMCYLDPSKAVEEDD 1508

  Fly  1859 DALGL----EQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECG 1919
            ..:|.    |:|.|...|:..            |.|:|.::..|.|||||||||||:|.||..||
Mouse  1509 FVVGFWNPSEENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTSCG 1561

  Fly  1920 PRGALLFMAWLGVRVLPITR-----------QLDGGNQEQRIPGS-TKP----NAENVVTVYGAW 1968
            .|.|.||:..||::|||:.:           |.:|.:|::.:.|| ..|    ::......||..
Mouse  1562 ERAAQLFLCSLGLKVLPVIKRTSREKALDPAQENGSSQQKSLSGSCASPVGPRSSAGKDLEYGCL 1626

  Fly  1969 PTPRSPLLHF-APNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLE 2032
            ..|  |...| .|:|.:.|:.|:||||.||:.:.|:|::::|||||.|||||..|.:||||||||
Mouse  1627 KIP--PRCMFDHPDAEKTLNHLISGFETFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLE 1689

  Fly  2033 FLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVID 2097
            |||||:||||||:||||||||||||.|||||||||||||||||||::.:||:|:.:||.|..|||
Mouse  1690 FLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVID 1754

  Fly  2098 RFVRIQQENGHCISEEYYL-LSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYS 2161
            .||:.|.|.......:..| .|||:.:..||:|||||:||:|||:||||::||.|||:|||.||.
Mouse  1755 DFVKFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYY 1819

  Fly  2162 NMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRI 2226
            .||.|.||:||.:||:||:|||||:|||||||...|:..|| :|||||:|..||.|:|:||:|||
Mouse  1820 PMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRI 1883

  Fly  2227 AKCTAAKCALRQLK 2240
            ||..||:.|||.||
Mouse  1884 AKSAAARRALRSLK 1897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690 65/209 (31%)
Dicer_PBD 240..344 CDD:277191 26/118 (22%)
DEAD-like_helicase_C 490..614 CDD:365791 59/124 (48%)
Dicer_dimer 825..916 CDD:397444 48/90 (53%)
PAZ_dicer_like 1091..1212 CDD:239209 56/123 (46%)
RIBOc 1724..1930 CDD:238333 101/298 (34%)
RIBOc 2008..2172 CDD:238333 109/164 (66%)
DSRM_DICER 2177..2240 CDD:380680 39/62 (63%)
Dicer1NP_683750.2 DEXHc_dicer 32..229 CDD:350792 65/209 (31%)
Dicer_PBD 261..355 CDD:277191 22/107 (21%)
SF2_C_dicer 362..554 CDD:350189 84/287 (29%)
Dicer_dimer 620..708 CDD:367465 48/90 (53%)
PAZ_dicer_like 876..998 CDD:239209 56/123 (46%)
RIBOc 1286..>1377 CDD:197778 58/90 (64%)
Rnc 1650..1902 CDD:223644 160/249 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850088
Domainoid 1 1.000 186 1.000 Domainoid score I3358
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H13251
Inparanoid 1 1.050 1077 1.000 Inparanoid score I249
Isobase 1 0.950 - 0 Normalized mean entropy S5945
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - oto92051
orthoMCL 1 0.900 - - OOG6_101152
Panther 1 1.100 - - LDO PTHR14950
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R301
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.840

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