Protein Alignment Dcr-1 and Dicer1

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: NP_001398758.1
• Gene: Dicer1 / 192119
• MGIID: 2177178
• Length: 1916
• Species: Mus musculus
• Alignment Length: 2419
• Identity: 778/2419 - (32%)
• Similarity: 1102/2419 - (45%)
• Gaps: 726/2419 - (30%)

  Fly     5 WCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR----RHGRVS 65
            |....:|..::|||.:|||||..|.:.|||:||...|.|.|||:.|.:||:.:.|    .|.:.:
Mouse    32 WQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHAKRT 96

  Fly    66 VYLSCEVGTSTEPC-SIYTMLTHLTDLRVWQEQPDMQIPFDHCW---------TDYHVSILRPEG 120
            |:|   |.::.:.. .:..:.|| :||:| .|..|:::  :..|         |.:.|.|:....
Mouse    97 VFL---VNSANQVAQQVSAVRTH-SDLKV-GEYSDLEV--NASWTKERWSQEFTKHQVLIMTCYV 154

  Fly   121 FLYLLETRELLLSSVELIVLEDCHDSAV---YQRIRPLFENHIMPAPPADRPRILGLAGPLHSAG 182
            .|.:|:...|.||.:.|:|.::||.:.:   |:.|..|.|:    .|..  ||||||...:.:..
Mouse   155 ALTVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCES----CPSC--PRILGLTASILNGK 213

  Fly   183 CELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHKS 247
            |:.::|...:..||:.:....|||:|:|.:.||.|:|.|.:|.|.||              |.:|
Mouse   214 CDPEELEEKIQKLERILRSDAETATDLVVLDRYTSQPCEIVVDCGPF--------------TDRS 264

  Fly   248 FLLDHRYDPYE--IYGTDQFMDELKDI--------PDPKVDPLNVINSLLVVLHEMGPWCTQRAA 302
            .|       ||  :...:..:|.:.|.        .|..:....:::....||..:||||..:.|
Mouse   265 GL-------YERLLMELEAALDFINDCNVAVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVA 322

  Fly   303 HHFYQCNEKLKVKTPHE-----RHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIE-RYS 361
            ....:   :|:....||     |.:||:  ..|.|.::::|||..|         |..::: :|.
Mouse   323 GMMVR---ELQKYIKHEQEELHRKFLLF--TDTLLRKIHALCEEYF---------SPASLDLKYV 373

  Fly   362 SPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADF--NRLSHTLESKCRMVDQMDQPPTETR 424
            :|||.:||:.||.:||.|           |.|.:..::  ||......|.....|..|....|.:
Mouse   374 TPKVMKLLEILRKYKPYE-----------RQQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEK 427

  Fly   425 ALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDG 489
                         |..:||        .|:|.
Mouse   428 -------------EKPETN--------FPSPF--------------------------------- 438

  Fly   490 SDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAELEHRRQEE 553
            ::.||.:|:..:.:||.||..|:.|..::||:|.::...:.|.. :.......|:.|.|.|:|||
Mouse   439 TNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRSKQMEAEFRKQEE 503

  Fly   554 VLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSY 618
            ||::||.|:.|:||.|||:|||:|:||||||||:|.||.||||||.||||||..:.:|:|
Mouse   504 VLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVML----- 563

  Fly   619 KSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQ 683
                                      ||:|
Mouse   564 --------------------------ADTD----------------------------------- 567

  Fly   684 PPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTS 748
                   |::..:::|..
Mouse   568 -------KIKSFEEDLKT----------------------------------------------- 578

  Fly   749 DTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKPH 813
                                     |:.||::|.:||:.:    .:.:||:..:.........|:
Mouse   579 -------------------------YKAIEKILRNKCSKS----ADGAEADVHAGVDDEDAFPPY 614

  Fly   814 LLT----GASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLK 874
            :|.    |..|.:.:||..:|:||||||||.||.|..  :|...|....| |..||.|||||||:
Mouse   615 VLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAP--KCRTRELPDGT-FYSTLYLPINSPLR 676

  Fly   875 HDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQ 939
            ..|||.||.:..||.|:.||..|.:||:|||||:.|.|:|||..:..|      ||:..||:  :
Mouse   677 ASIVGPPMDSVRLAERVVALICCEKLHKIGELDEHLMPVGKETVKYEE------ELDLHDEE--E 733

  Fly   940 LSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDA 1004
            .|...|||:|||||.|.|.|.....:..|....|||||.|.:.|..|:|:|.|.|.||:|||||.
Mouse   734 TSVPGRPGSTKRRQCYPKAIPECLRESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDT 798

  Fly  1005 QQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKF 1069
            .:.|||||.|.||::..|.::||||||.:|:||.|....|:.:.:..|.....|.|:::|||:|.
Mouse   799 TRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELITRLHQYIFSHILRLEKP 863

  Fly  1070 LMLFDPDSTENCVFIVP-TVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQP---FDPQR 1130
            .:.|.|...|:...::| .|...:|...||::|:|.|:.:...:  .:|..:...:.   |..:.
Mouse   864 ALEFKPTGAESAYCVLPLNVVNDSGTLDIDFKFMEDIEKSEARI--GIPSTKYSKETPFVFKLED 926

  Fly  1131 FQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVD 1195
            :||||::|.|||.|||..||||::...|:|||.||...|.||..||..||.|.:.|.:|||||||
Mouse   927 YQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVD 991

  Fly  1196 HTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPC 1260
            |||:|||.||||::|:||.|||.||.|.::||.|:|:.|||||||||.:||.||||||.|||||.
Mouse   992 HTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPS 1056

  Fly  1261 ILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQ-----KES 1320
            ||||::.||.|:::|.|.::|.|:|.:.: ..||.:|.|||||      |||.:||.     ..|
Mouse  1057 ILYRLHCLLTAEELRAQTASDAGVGVRSL-PVDFRYPNLDFGW------KKSIDSKSFISSCNSS 1114

  Fly  1321 LKDDTINGKDLADV---------EKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFI 1376
            |.:.....|....|         ..:|:.|        ..|::..:...|..|...|||
Mouse  1115 LAESDNYCKHSTTVVPEHAAHQGATRPSLE--------NHDQMSVNCKRLPAESPAKLQ------ 1165

  Fly  1377 EIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKS 1441
                  ::::.|:.:.|                                         |.
Mouse  1166 ------SEVSTDLTAIN-----------------------------------------GL----- 1178

  Fly  1442 SQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYD----DDDNAGPLNYMHHNYSSDDDDVADDIDA 1502
            |.||                     |....|||    |......|||.
Mouse  1179 SYNK---------------------NLANGSYDLVNRDFCQGNQLNYF----------------- 1205

  Fly  1503 GRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPA---- 1563
                                    ||...:|.|.:...|     ||     :.:|:|.:|:
Mouse  1206 ------------------------KQEIPVQPTTSYPIQ-----NL-----YNYENQPKPSNECP 1236

  Fly  1564 --TIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAK 1626
              :..|.:..|...|                   ||.:.|.....:||..:|.|
Mouse  1237 LLSNTYLDGNANTST-------------------SDGSPAVSTMPAMMNAVKAL----------- 1271

  Fly  1627 KLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEP 1691
                                                                     .:|::.|
Mouse  1272 ---------------------------------------------------------KDRMDSE- 1278

  Fly  1692 PTSTKAITSAILPAGFSFDRQPDLVGHP----GPSPSIILQALTMSNANDGINLERLETIGDSFL 1752
                                |...||:.    ||:|.:||||||:|||:||.||||||.:|||||
Mouse  1279 --------------------QSPSVGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFL 1323

  Fly  1753 KYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYV- 1816
            |:||||||:.||.:.|||:||::|||:|:|.||||||::|.|...|:.:.|:|..|||||.|.|
Mouse  1324 KHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVN 1388

  Fly  1817 ---------------------------------------PKE------------------LEKAL 1824
                                                   |||                  ::..|
Mouse  1389 QDKSNSEKWEKDEMTKDCLLANGKLGEACEEEEDLTWRAPKEEAEDEDDFLEYDQEHIQFIDSML 1453

  Fly  1825 I--------------EAKIPTHHWKL------------ADLLDIKNLSSVQIC-----EMVREKA 1858
            :              .|....:.||:            :.|.|....|...:|     :.|.|..
Mouse  1454 MGSGAFVRKISLSPFSASDSAYEWKMPKKASLGSMPFASGLEDFDYSSWDAMCYLDPSKAVEEDD 1518

  Fly  1859 DALGL----EQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECG 1919
            ..:|.    |:|.|...|:..            |.|:|.::..|.|||||||||||:|.||..||
Mouse  1519 FVVGFWNPSEENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTSCG 1571

  Fly  1920 PRGALLFMAWLGVRVLPITR-----------QLDGGNQEQRIPGS-TKP----NAENVVTVYGAW 1968
            .|.|.||:..||::|||:.:           |.:|.:|::.:.|| ..|    ::......||..
Mouse  1572 ERAAQLFLCSLGLKVLPVIKRTSREKALDPAQENGSSQQKSLSGSCASPVGPRSSAGKDLEYGCL 1636

  Fly  1969 PTPRSPLLHF-APNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLE 2032
            ..|  |...| .|:|.:.|:.|:||||.||:.:.|:|::::|||||.|||||..|.:||||||||
Mouse  1637 KIP--PRCMFDHPDAEKTLNHLISGFETFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLE 1699

  Fly  2033 FLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVID 2097
            |||||:||||||:||||||||||||.|||||||||||||||||||::.:||:|:.:||.|..|||
Mouse  1700 FLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVID 1764

  Fly  2098 RFVRIQQENGHCISEEYYL-LSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYS 2161
            .||:.|.|.......:..| .|||:.:..||:|||||:||:|||:||||::||.|||:|||.||.
Mouse  1765 DFVKFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYY 1829

  Fly  2162 NMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRI 2226
            .||.|.||:||.:||:||:|||||:|||||||...|:..|| :|||||:|..||.|:|:||:|||
Mouse  1830 PMMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRI 1893

  Fly  2227 AKCTAAKCALRQLK 2240
            ||..||:.|||.||
Mouse  1894 AKSAAARRALRSLK 1907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	65/209 (31%)
		Dicer_PBD	240..344	CDD:277191	26/118 (22%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	59/124 (48%)
		Dicer_dimer	825..916	CDD:460900	48/90 (53%)
		PAZ_dicer_like	1091..1212	CDD:239209	56/123 (46%)
		RIBOc	1724..1930	CDD:238333	101/298 (34%)
		RIBOc	2008..2172	CDD:238333	109/164 (66%)
		DSRM_DICER	2177..2240	CDD:380680	39/62 (63%)
Dicer1	NP_001398758.1	DEXHc_dicer	42..239	CDD:350792	65/209 (31%)
		DECH box	175..178		0/2 (0%)
		Required for interaction with PRKRA and TARBP2. /evidence=ECO:0000250	256..595		126/587 (21%)
		Dicer_PBD	271..365	CDD:277191	22/107 (21%)
		SF2_C_dicer	372..564	CDD:350189	84/287 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..433		5/36 (14%)
		Dicer_dimer	630..718	CDD:460900	48/90 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	726..745		8/20 (40%)
		PAZ_dicer_like	886..1008	CDD:239209	56/123 (46%)
		RIBOc	1296..>1387	CDD:197778	58/90 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1598..1626		6/27 (22%)
		RIBOc	1676..1840	CDD:238333	109/163 (67%)
		DSRM_DICER	1845..1907	CDD:380680	39/62 (63%)