DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and drh-1

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_501018.1	Gene:	drh-1 / 177425	WormBaseID:	WBGene00001090	Length:	1037	Species:	Caenorhabditis elegans

Alignment Length:	846	Identity:	147/846 - (17%)
Similarity:	298/846 - (35%)	Gaps:	273/846 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RDFQVELLATAYE-RNTIICLGHRSSKEFIALKLLQELSRRARRHGRVSVYLSCEVGT---STEP 78
            |::|.||...|.: :|||:.....|.|..||..:::|........|:....|.....:   :.:.
Worm   294 RNYQEELCQVALQGKNTIVTAPTGSGKTVIAANIIKEHFESRSSEGKRFKALFMTPNSMILNQQA 358

  Fly    79 CSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEGFLYLL---------ETR--ELLL 132
            .||.:.|.|:...::.|...:  :|..:......:.:..|:..:.|.         |:|  :..|
Worm   359 ASISSYLDHVYHTQIIQGSDN--VPTRNVIQSKDLIVATPQMIVNLCNEHRNSLDDESRLDQFFL 421

  Fly   133 SSVELIVLEDCHD---SAVYQRIRPLF----------ENHIMPAPPADRPRILGLAGPLHSAGCE 184
            |:..:|..::||:   ::.|..|...:          |.|.:       |:|:|
Worm   422 STFTIIFFDECHNTVKNSPYSNIMREYHYLKNMGNMPEGHSL-------PQIIG----------- 468

  Fly   185 LQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIV-QCAPFEMDELSLVLADVLNTHKSF 248
               |:|.|.|.:::                .|.:...||. .||..::.:||:|        |..
Worm   469 ---LTASLGTGDKN----------------DCLQVRNYIAGLCASMDVKDLSIV--------KDN 506

  Fly   249 LLDHR-YDPYEIYGTDQFMDELKDIPDPKV--------DPLNVI-NSLLVVLHEMGPWCTQRAAH 303
            |.:.| |.|.              :|| ||        .|:.:. |.|.:::.|:.........:
Worm   507 LEELRGYSPI--------------VPD-KVLLCERSTDGPIGMFTNRLTLMMQEVEGLIRTALRN 556

  Fly   304 HFYQCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHR-------HLGSGSDSRQTIERYS 361
            ......::.:::|. ||.:    ...::.:...:..|||.::       :|.||:..|:|..|..
Worm   557 EHIGIEQRRQIETT-ERDF----RPDSSFLDPPADKEHAGYQNWVCNQMNLVSGTSFRETGTRTI 616

  Fly   362 SPKVRRLLQTLRC-------FKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQ---- 415
            ..:...:|:...|       |.||..         :.:..|:.::...:.|: :..|:.::
Worm   617 INEALDVLKECFCTLSYNINFHPEVA---------LNYLKDEMEYRTPNFTV-NMIRIWERYHNQ 671

  Fly   416 -MDQPPTETRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYT 479
             :.....|...:..|::.|:.....|..:|:
Worm   672 LVGTGSAENPMISKTVQYIVEQNLQRADSRT---------------------------------- 702

  Fly   480 RRHHRDHNDGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEA 544
                            :|:....:.|.:|.::|.  |..:..:..::.::.:. :...|....:.
Worm   703 ----------------IIFVRTRYEATILNKVLN--SNEELLMLGIKSEWMSG-LNKSTASSADI 748

  Fly   545 ELEHRRQEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAY 609
            ....::|.|.||.|...:..:|:.|||.|||:|||:|:||::::..|...::||.:||.||..:.
Worm   749 SASKQKQMEKLKMFADGEIRILVSTSVAEEGLDVPECSLVIKYNYATNEIAHVQRRGRGRALNSE 813

  Fly   610 HVILVAPSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKI 674
            .|::         ..|:.|.|:            |:::...:|.|..              |:.:
Worm   814 CVLI---------TNSIALRDQ------------ESNNRDKESLMSE--------------TISL 843

  Fly   675 L--NPEVFSKQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRF--- 734
            :  :|..|.|     |      :.:|         ||.....:...:|..::...||.:|..
Worm   844 IQNSPAEFRK-----C------VDEE---------SNKIWPRILREDTDKAQKIEEQINRNIVYK 888

  Fly   735 ----QCELSSLTEPEDTSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQ 795
                :||                     ::..|:||:..:..||...:....|....|...:::|
Worm   889 IICKKCE---------------------AILCTSKDIRSRNTQYLVCDPGFWSLVRKTRLTDEQQ 932

  Fly   796 S 796
            :
Worm   933 A 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690	41/217 (19%)
		Dicer_PBD	240..344	CDD:277191	19/113 (17%)
		DEAD-like_helicase_C	490..614	CDD:365791	32/123 (26%)
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333
		RIBOc	2008..2172	CDD:238333
		DSRM_DICER	2177..2240	CDD:380680
drh-1	NP_501018.1	HTH	166..227	CDD:304362
		MPH1	294..884	CDD:224036	136/774 (18%)
		DEXDc	308..473	CDD:238005	34/187 (18%)
		Helicase_C	687..809	CDD:278689	32/174 (18%)
		RLR_C_like	888..1001	CDD:300620	10/67 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1337630at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950