DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and dcr-1

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_498761.2	Gene:	dcr-1 / 176138	WormBaseID:	WBGene00000939	Length:	1910	Species:	Caenorhabditis elegans

Alignment Length:	2362	Identity:	715/2362 - (30%)
Similarity:	1048/2362 - (44%)	Gaps:	615/2362 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQE--------LSRRARR----------- 60
            |.|||:|||||..|.::|||:.||..|.|.|||:.||:|        |.:..:|
Worm    11 FNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLV 75

  Fly    61 -----HGRVSVYLSCEVGTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEG 120
                 |  :.|:.|.:||          .:...|...:|    |.:...|.....:||.::..:.
Worm    76 EQQAIH--IEVHTSFKVG----------QVHGQTSSGLW----DSKEQCDQFMKRHHVVVITAQC 124

  Fly   121 FLYLLETRELLLSSVELIVLEDCHDSAVYQR-IRPLFENHIMPAPPADRPRILGLAGPLHSAGCE 184
            .|.|:....|.:..:.:::.::||.:...|. .|.:..::.:.......||:|||...|..|...
Worm   125 LLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVA 189

  Fly   185 LQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHKSFL 249
            .::|...|..||.::...||||||:|::.:|.::|:|.::.|..||:..|.:...|.:
Worm   190 PEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTV------- 247

  Fly   250 LDHRYDPYEIYG-TDQFMDELKDI-PDPKVDPLNVINSLL----VVLHEMGPWCTQRAAHHFYQC 308
                   .||:. |..|::...:. ||..:||...|...|    .|..::|||...|.|    |.
Worm   248 -------IEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTA----QV 301

  Fly   309 NEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRL--LQT 371
            .||...|           ::.:.::...:|      |.|.....|..||:|...|:::::  ::.
Worm   302 WEKELGK-----------IIKSQVLPDKTL------RFLNMAKTSMITIKRLLEPEMKKIKSIEA 349

  Fly   372 LRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTETRALVATLEQILHT 436
            ||.:.|:.                                               |..|.:||.|
Worm   350 LRPYVPQR-----------------------------------------------VIRLFEILET 367

  Fly   437 TEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDTLCALIYCNQ 501
                                         .|....:.|.::....|          |.|:|:.:|
Worm   368 -----------------------------FNPEFQKERMKLEKAEH----------LSAIIFVDQ 393

  Fly   502 NHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQEEVLKRFRMHDCNVL 566
            .:.|..|..::..|...:|..||:...|... .:.......:::..|:||.|||:||..::.|.|
Worm   394 RYIAYSLLLMMRHIKSWEPKFKFVNPDYVVG-ASGRNLASSDSQGLHKRQTEVLRRFHRNEINCL 457

  Fly   567 IGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSYKSPTVGSVQLTDR 631
            |.|||||||:||.:||||:::|.|...|||||.|||||.|.:.:||.|...
Worm   458 IATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEK-------------- 508

  Fly   632 SHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQPPTACDIKLQEIQ 696
                     ||...|||..|
Worm   509 ---------DTAACDSDLKD--------------------------------------------- 519

  Fly   697 DELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTSDTTAEIDTAHSLA 761

Worm   520 ----------------------------------------------------------------- 519

  Fly   762 STTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKPHLL--TGASVDLGS 824
                        :::||::|||:......|.::.|  :||.......:.:|:::  |||::.:.:
Worm   520 ------------FQQIEKILLSRHRTVNNPIEDDS--DRFEEFDVDSQMEPYVVEKTGATLKMST 570

  Fly   825 AIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLKHDIV-GLPMPTQTLA 888
            ||||:|:||::||||.||:|....:....|..|||.:...|.||||||:||.|| ..|||.:..|
Worm   571 AIALINRYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTA 635

  Fly   889 RRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLSDEPRP------G 947
            :...||:||.:||..|||||.|.|.|:|....|        ||..||:    .||..|      |
Worm   636 QMAVALEACRQLHLEGELDDNLLPKGRESIAKL--------LEHIDEE----PDEYAPGIAAKVG 688

  Fly   948 TTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDAQQGFGILT 1012
            ::||:|.|.|:||....:....|...|::|..:|..........|.:.||...|.:.:..||.|:
Worm   689 SSKRKQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFLS 753

  Fly  1013 TKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKFLMLFDPDS 1077
            .|.|||:..|.:|.|.|.:||.|.:|.::..:|:.|:..|..|.||.||.||::.|...| :.|.
Worm   754 AKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGNL-EFDG 817

  Fly  1078 TENC---VFIVPTVKAPAGGKH-IDWQFLELIQANGNTMPRAVPDEERQAQPFDPQRFQDAVVMP 1138
            |.|.   ..|||..|......: |:.:::..:.||...|||...||.|:...|:.:.::||:|||
Worm   818 TSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMP 882

  Fly  1139 WYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSARLNF 1203
            ||||.:||.::|||||.|...|.|.||..::.||..|::.||.|.|.:.:|.|||||.||.|||.
Worm   883 WYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNL 947

  Fly  1204 LTPRYVNRKGVALPTSSEETKR--------AKRENL-----EQKQILVPELCTVHPFPASLWRTA 1255
            |.||..|:...:...|:..|..        :|..|.     .|:|||||||..:||..|:||...
Worm   948 LQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVI 1012

  Fly  1256 VCLPCILYRINGLLLADDIRKQVSADLGLGRQQIE-DEDFEWPMLDFGWSLSEVLKKSRESKQKE 1319
            ..||.|.||:|.|||.|::|:.:... ..|:::.: |::.||..|.:.....|  |::...|:.:
Worm  1013 AALPSIFYRVNQLLLTDELRETILVK-AFGKEKTKLDDNVEWNSLAYATEYEE--KQTIIVKKIQ 1074

  Fly  1320 SLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWSND 1384
            .|:|  :|.|.:.|.|:     ||:     ::||::        :|||       ...||.|..:
Worm  1075 QLRD--LNQKSIEDQER-----ETR-----ENDKID--------DGEE-------LFNIGVWDPE 1112

  Fly  1385 MA----------DDIASFNQED-------------DDEDDAFHLPVLPANVKFCDQQTRYGSPTF 1426
            .|          ||......:|             .||||  .||.:     ..|...|..|.
Worm  1113 EAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDD--ELPFV-----MHDYTARLTSN-- 1168

  Fly  1427 WDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNS------LGSSYDDDDNAGPLNYM 1485
               .||...:.|.:|.  ...|.|...||        :.|||      ||       ..|.||..
Worm  1169 ---RNGIGAWSGSESI--VPSGWGDWDGP--------EPDNSPMPFQILG-------GPGGLNVQ 1213

  Fly  1486 HHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQE-VEKRQKQLSIIQATNANERQYQQTKNLL 1549
                       |...|.||:...|...:...:|.|| .....|||:      ..|.|:::.:|.|
Worm  1214 -----------ALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLT------KEEEQFKKLQNDL 1261

  Fly  1550 IGFNFKH-----------EDQKEPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQV 1603
            :    |.           ||.::|.  |.|:::     .:|..|              |..|.|.
Worm  1262 L----KQAKERLEALEMSEDMEKPR--RLEDTV-----NLEDYG--------------DDQENQE 1301

  Fly  1604 AKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYN 1668
            .:.:.....|.    ::|::....:|.|::..:.|    ||......|:|...|:
Worm  1302 DENTPTNFPKT----IDEEIEELSIGARKKQEIDD----NAAKTDVLERENCEVL---------- 1348

  Fly  1669 DHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGH------PGPSPSIIL 1727
               .:.::||.....:|:       .:|||...::.     .|..:.|.|      .|.||.::|
Worm  1349 ---PVAINEKSRSFSFEK-------ESKAINGRLIR-----QRSEEYVSHIDSDIGLGVSPCLLL 1398

  Fly  1728 QALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRK 1792
            .|||.|||.||::|||.|||||||||:|.|.|||.|..:.||||||..|||:|:|.||||||::.
Worm  1399 TALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKL 1463

  Fly  1793 RLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIK----NLSSVQICEM 1853
            .:.:.::|.||:.||:||||||              |||..:|..:..|.:    .:..:...::
Worm  1464 GIPQLIVANKFDAHDSWLPPCY--------------IPTCDFKAPNTDDAEEKDNEIERILDGQV 1514

  Fly  1854 VREKAD-ALGLEQNGGAQNGQLDD------------SNDSCNDFSCFIPYNLVSQHSIPDKSIAD 1905
            :.||.: ..|.:..|.......|.            .||..:.    :||||::|..|.||||||
Worm  1515 IEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISP----LPYNLLTQQHISDKSIAD 1575

  Fly  1906 CVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPT 1970
            .||||||.:|:..||...|..|.|:|::|:    |.|   |:..:|
Worm  1576 AVEALIGVHLLTLGPNPTLKVMNWMGLKVI----QKD---QKSDVP------------------- 1614

  Fly  1971 PRSPLLHFA-----PNAT-EELDQLLSGFE--EFEESLGYKFRDRSYLLQAMTHASYTPNRLTDC 2027
              ||||.|.     |||: ..|:.|...|:  :.||.:||:|::|:||:||.|||||..||:|.|
Worm  1615 --SPLLRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGC 1677

  Fly  2028 YQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGL 2092
            ||||||||||||||:|||:|:||.||:|||.|||||||||||||||||||:..|.|.|..:.|||
Worm  1678 YQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGL 1742

  Fly  2093 NDVIDRFVRIQQENG---HCISEEYYLLSEEECDDA--EDVEVPKALGDVFESIAGAIFLDSNMS 2152
            ..:|::||::..|..   :..:|.|.:.:|||.|:.  ||:|||||:||:|||:||||:|||..:
Worm  1743 YHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRN 1807

  Fly  2153 LDVVWHVYSNMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTF 2217
            ||..|.|..:||...||....:.|:||||||:|.|....:|.|.|::.:..:|||||:|.....|
Worm  1808 LDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRF 1872

  Fly  2218 RGIGRNYRIAKCTAAKCALRQL 2239
            .|:||||||||.||||.||:.|
Worm  1873 TGMGRNYRIAKATAAKRALKYL 1894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690	58/217 (27%)
		Dicer_PBD	240..344	CDD:277191	22/109 (20%)
		DEAD-like_helicase_C	490..614	CDD:365791	50/123 (41%)
		Dicer_dimer	825..916	CDD:397444	47/91 (52%)
		PAZ_dicer_like	1091..1212	CDD:239209	53/121 (44%)
		RIBOc	1724..1930	CDD:238333	90/222 (41%)
		RIBOc	2008..2172	CDD:238333	100/168 (60%)
		DSRM_DICER	2177..2240	CDD:380680	34/63 (54%)
dcr-1	NP_498761.2	DEXDc	27..183	CDD:238005	38/171 (22%)
		Dicer_PBD	248..343	CDD:277191	28/115 (24%)
		HELICc	<434..498	CDD:197757	36/63 (57%)
		Dicer_dimer	572..659	CDD:281376	44/86 (51%)
		PAZ_dicer_like	836..956	CDD:239209	53/119 (45%)
		RIBOc	1395..1520	CDD:197778	62/138 (45%)
		Rnc	1639..1900	CDD:223644	142/256 (55%)
		RIBOc	1659..1824	CDD:238333	98/164 (60%)
		DSRM	1834..1894	CDD:238007	32/59 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167254
Domainoid	1	1.000	150	1.000	Domainoid score	I2707
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13251
Inparanoid	1	1.050	946	1.000	Inparanoid score	I169
Isobase	1	0.950	-	0	Normalized mean entropy	S5945
OMA	1	1.010	-	-		QHG57860
OrthoDB	1	1.010	-	-		D126291at33208
OrthoFinder	1	1.000	-	-		FOG0002051
OrthoInspector	1	1.000	-	-		oto20117
orthoMCL	1	0.900	-	-		OOG6_101152
Panther	1	1.100	-	-	LDO	PTHR14950
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	1	1.000	-	-		X1728
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.840