Protein Alignment Dcr-1 and dcr-1

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: NP_498761.2
• Gene: dcr-1 / 176138
• WormBaseID: WBGene00000939
• Length: 1910
• Species: Caenorhabditis elegans
• Alignment Length: 2362
• Identity: 715/2362 - (30%)
• Similarity: 1048/2362 - (44%)
• Gaps: 615/2362 - (26%)

  Fly    15 FTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQE--------LSRRARR----------- 60
            |.|||:|||||..|.::|||:.||..|.|.|||:.||:|        |.:..:|
 Worm    11 FNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLV 75

  Fly    61 -----HGRVSVYLSCEVGTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEG 120
                 |  :.|:.|.:||          .:...|...:|    |.:...|.....:||.::..:.
 Worm    76 EQQAIH--IEVHTSFKVG----------QVHGQTSSGLW----DSKEQCDQFMKRHHVVVITAQC 124

  Fly   121 FLYLLETRELLLSSVELIVLEDCHDSAVYQR-IRPLFENHIMPAPPADRPRILGLAGPLHSAGCE 184
            .|.|:....|.:..:.:::.::||.:...|. .|.:..::.:.......||:|||...|..|...
 Worm   125 LLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVA 189

  Fly   185 LQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHKSFL 249
            .::|...|..||.::...||||||:|::.:|.::|:|.::.|..||:..|.:...|.:
 Worm   190 PEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTV------- 247

  Fly   250 LDHRYDPYEIYG-TDQFMDELKDI-PDPKVDPLNVINSLL----VVLHEMGPWCTQRAAHHFYQC 308
                   .||:. |..|::...:. ||..:||...|...|    .|..::|||...|.|    |.
 Worm   248 -------IEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTA----QV 301

  Fly   309 NEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRL--LQT 371
            .||...|           ::.:.::...:|      |.|.....|..||:|...|:::::  ::.
 Worm   302 WEKELGK-----------IIKSQVLPDKTL------RFLNMAKTSMITIKRLLEPEMKKIKSIEA 349

  Fly   372 LRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTETRALVATLEQILHT 436
            ||.:.|:.                                               |..|.:||.|
 Worm   350 LRPYVPQR-----------------------------------------------VIRLFEILET 367

  Fly   437 TEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDTLCALIYCNQ 501
                                         .|....:.|.::....|          |.|:|:.:|
 Worm   368 -----------------------------FNPEFQKERMKLEKAEH----------LSAIIFVDQ 393

  Fly   502 NHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQEEVLKRFRMHDCNVL 566
            .:.|..|..::..|...:|..||:...|... .:.......:::..|:||.|||:||..::.|.|
 Worm   394 RYIAYSLLLMMRHIKSWEPKFKFVNPDYVVG-ASGRNLASSDSQGLHKRQTEVLRRFHRNEINCL 457

  Fly   567 IGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSYKSPTVGSVQLTDR 631
            |.|||||||:||.:||||:::|.|...|||||.|||||.|.:.:||.|...
 Worm   458 IATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEK-------------- 508

  Fly   632 SHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQPPTACDIKLQEIQ 696
                     ||...|||..|
 Worm   509 ---------DTAACDSDLKD--------------------------------------------- 519

  Fly   697 DELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTSDTTAEIDTAHSLA 761
                                                                             
 Worm   520 ----------------------------------------------------------------- 519

  Fly   762 STTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKPHLL--TGASVDLGS 824
                        :::||::|||:......|.::.|  :||.......:.:|:::  |||::.:.:
 Worm   520 ------------FQQIEKILLSRHRTVNNPIEDDS--DRFEEFDVDSQMEPYVVEKTGATLKMST 570

  Fly   825 AIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLKHDIV-GLPMPTQTLA 888
            ||||:|:||::||||.||:|....:....|..|||.:...|.||||||:||.|| ..|||.:..|
 Worm   571 AIALINRYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTA 635

  Fly   889 RRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLSDEPRP------G 947
            :...||:||.:||..|||||.|.|.|:|....|        ||..||:    .||..|      |
 Worm   636 QMAVALEACRQLHLEGELDDNLLPKGRESIAKL--------LEHIDEE----PDEYAPGIAAKVG 688

  Fly   948 TTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDAQQGFGILT 1012
            ::||:|.|.|:||....:....|...|::|..:|..........|.:.||...|.:.:..||.|:
 Worm   689 SSKRKQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFLS 753

  Fly  1013 TKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKFLMLFDPDS 1077
            .|.|||:..|.:|.|.|.:||.|.:|.::..:|:.|:..|..|.||.||.||::.|...| :.|.
 Worm   754 AKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGNL-EFDG 817

  Fly  1078 TENC---VFIVPTVKAPAGGKH-IDWQFLELIQANGNTMPRAVPDEERQAQPFDPQRFQDAVVMP 1138
            |.|.   ..|||..|......: |:.:::..:.||...|||...||.|:...|:.:.::||:|||
 Worm   818 TSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMP 882

  Fly  1139 WYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSARLNF 1203
            ||||.:||.::|||||.|...|.|.||..::.||..|::.||.|.|.:.:|.|||||.||.|||.
 Worm   883 WYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNL 947

  Fly  1204 LTPRYVNRKGVALPTSSEETKR--------AKRENL-----EQKQILVPELCTVHPFPASLWRTA 1255
            |.||..|:...:...|:..|..        :|..|.     .|:|||||||..:||..|:||...
 Worm   948 LQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVI 1012

  Fly  1256 VCLPCILYRINGLLLADDIRKQVSADLGLGRQQIE-DEDFEWPMLDFGWSLSEVLKKSRESKQKE 1319
            ..||.|.||:|.|||.|::|:.:... ..|:::.: |::.||..|.:.....|  |::...|:.:
 Worm  1013 AALPSIFYRVNQLLLTDELRETILVK-AFGKEKTKLDDNVEWNSLAYATEYEE--KQTIIVKKIQ 1074

  Fly  1320 SLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWSND 1384
            .|:|  :|.|.:.|.|:     ||:     ::||::        :|||       ...||.|..:
 Worm  1075 QLRD--LNQKSIEDQER-----ETR-----ENDKID--------DGEE-------LFNIGVWDPE 1112

  Fly  1385 MA----------DDIASFNQED-------------DDEDDAFHLPVLPANVKFCDQQTRYGSPTF 1426
            .|          ||......:|             .||||  .||.:     ..|...|..|.
 Worm  1113 EAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDD--ELPFV-----MHDYTARLTSN-- 1168

  Fly  1427 WDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNS------LGSSYDDDDNAGPLNYM 1485
               .||...:.|.:|.  ...|.|...||        :.|||      ||       ..|.||..
 Worm  1169 ---RNGIGAWSGSESI--VPSGWGDWDGP--------EPDNSPMPFQILG-------GPGGLNVQ 1213

  Fly  1486 HHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQE-VEKRQKQLSIIQATNANERQYQQTKNLL 1549
                       |...|.||:...|...:...:|.|| .....|||:      ..|.|:::.:|.|
 Worm  1214 -----------ALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLT------KEEEQFKKLQNDL 1261

  Fly  1550 IGFNFKH-----------EDQKEPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQV 1603
            :    |.           ||.::|.  |.|:::     .:|..|              |..|.|.
 Worm  1262 L----KQAKERLEALEMSEDMEKPR--RLEDTV-----NLEDYG--------------DDQENQE 1301

  Fly  1604 AKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYN 1668
            .:.:.....|.    ::|::....:|.|::..:.|    ||......|:|...|:
 Worm  1302 DENTPTNFPKT----IDEEIEELSIGARKKQEIDD----NAAKTDVLERENCEVL---------- 1348

  Fly  1669 DHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGH------PGPSPSIIL 1727
               .:.::||.....:|:       .:|||...::.     .|..:.|.|      .|.||.::|
 Worm  1349 ---PVAINEKSRSFSFEK-------ESKAINGRLIR-----QRSEEYVSHIDSDIGLGVSPCLLL 1398

  Fly  1728 QALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRK 1792
            .|||.|||.||::|||.|||||||||:|.|.|||.|..:.||||||..|||:|:|.||||||::.
 Worm  1399 TALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKL 1463

  Fly  1793 RLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIK----NLSSVQICEM 1853
            .:.:.::|.||:.||:||||||              |||..:|..:..|.:    .:..:...::
 Worm  1464 GIPQLIVANKFDAHDSWLPPCY--------------IPTCDFKAPNTDDAEEKDNEIERILDGQV 1514

  Fly  1854 VREKAD-ALGLEQNGGAQNGQLDD------------SNDSCNDFSCFIPYNLVSQHSIPDKSIAD 1905
            :.||.: ..|.:..|.......|.            .||..:.    :||||::|..|.||||||
 Worm  1515 IEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISP----LPYNLLTQQHISDKSIAD 1575

  Fly  1906 CVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPT 1970
            .||||||.:|:..||...|..|.|:|::|:    |.|   |:..:|
 Worm  1576 AVEALIGVHLLTLGPNPTLKVMNWMGLKVI----QKD---QKSDVP------------------- 1614

  Fly  1971 PRSPLLHFA-----PNAT-EELDQLLSGFE--EFEESLGYKFRDRSYLLQAMTHASYTPNRLTDC 2027
              ||||.|.     |||: ..|:.|...|:  :.||.:||:|::|:||:||.|||||..||:|.|
 Worm  1615 --SPLLRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGC 1677

  Fly  2028 YQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGL 2092
            ||||||||||||||:|||:|:||.||:|||.|||||||||||||||||||:..|.|.|..:.|||
 Worm  1678 YQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGL 1742

  Fly  2093 NDVIDRFVRIQQENG---HCISEEYYLLSEEECDDA--EDVEVPKALGDVFESIAGAIFLDSNMS 2152
            ..:|::||::..|..   :..:|.|.:.:|||.|:.  ||:|||||:||:|||:||||:|||..:
 Worm  1743 YHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRN 1807

  Fly  2153 LDVVWHVYSNMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTF 2217
            ||..|.|..:||...||....:.|:||||||:|.|....:|.|.|::.:..:|||||:|.....|
 Worm  1808 LDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRF 1872

  Fly  2218 RGIGRNYRIAKCTAAKCALRQL 2239
            .|:||||||||.||||.||:.|
 Worm  1873 TGMGRNYRIAKATAAKRALKYL 1894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	58/217 (27%)
		Dicer_PBD	240..344	CDD:277191	22/109 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	50/123 (41%)
		Dicer_dimer	825..916	CDD:460900	47/91 (52%)
		PAZ_dicer_like	1091..1212	CDD:239209	53/121 (44%)
		RIBOc	1724..1930	CDD:238333	90/222 (41%)
		RIBOc	2008..2172	CDD:238333	100/168 (60%)
		DSRM_DICER	2177..2240	CDD:380680	34/63 (54%)
dcr-1	NP_498761.2	DEXHc_dicer	11..213	CDD:350792	58/217 (27%)
		Dicer_PBD	248..343	CDD:277191	28/115 (24%)
		SF2_C_dicer	357..505	CDD:350189	58/234 (25%)
		Dicer_dimer	571..664	CDD:460900	47/92 (51%)
		PAZ_dicer_like	836..956	CDD:239209	53/119 (45%)
		RIBOc	1395..1520	CDD:197778	62/138 (45%)
		RIBOc	1659..1824	CDD:238333	98/164 (60%)
		DSRM_DICER	1832..1895	CDD:380680	34/63 (54%)