DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and Drosha

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	XP_006520084.1	Gene:	Drosha / 14000	MGIID:	1261425	Length:	1393	Species:	Mus musculus

Alignment Length:	1342	Identity:	253/1342 - (18%)
Similarity:	435/1342 - (32%)	Gaps:	502/1342 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1113 PRAVPDEERQAQPFDPQRFQDAVVMPWYRNQDQPQY-----FYVAEICPHLSPLSC---FPGDNY 1169
            ||....|..:.:..:..|.::|...|......:.:|     .|...:.|  .|..|   .||:
Mouse   295 PRHRSYERSRERDRERHRHREARRSPSLERSYKKEYKRSGRSYALPVAP--EPAGCTPELPGE-- 355

  Fly  1170 RTFKHYYLVKYGLTIQNTSQPLLDVDHTS-------ARLNFLTPRYVNRKGVALPTSSEETKRAK 1227
                   ::|   |.::.:.|..:|:|.|       ||......|:.:.:|.....:....|..:
Mouse   356 -------MIK---TTESWAPPPENVNHRSPSREKKRARWEEEKDRWSDSQGSGKEKNYTSIKEKE 410

  Fly  1228 RENL-------EQKQILVPELCTVHPFPASLWRTAVCLPCILYRINGLLLADDIRKQVSADLGLG 1285
            .|.:       |::::|.|           :|  ..|.....|      .:.|...||.....:|
Mouse   411 AEEVPPEKTEEEEEELLKP-----------VW--IRCTHSESY------YSSDPMDQVGDSTVVG 456

  Fly  1286 RQQIED--EDFEWPMLDFG------------W-----SLSEVLKKSRESKQKESLKDDTINGKD- 1330
            ..::.|  :.||   .:.|            |     .|.|.|:.|.|| :.|:..|.|.:...
Mouse   457 TSRLRDLYDKFE---EELGNRQEKAKAARPPWEPPKTKLDEDLESSSES-ECETDDDSTCSSSSD 517

  Fly  1331 ------LADVEKK---PTSEETQL---DKDSKDD--------KVEKSAI-ELIIEGEEKLQEADD 1374
                  :|::::|   |.....:|   |....:|        |..::.| ..|..|||.::....
Mouse   518 SEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRP 582

  Fly  1375 F-----------IEIGTWSNDMADDIASFNQEDDDEDDAF-------HLP--------------- 1406
            .           |.:...:|.:.|.....  |.||.:..|       |.|
Mouse   583 MTNNAGRLFHYRITVSPPTNFLTDRPTVI--EYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNID 645

  Fly  1407 --------VLPANVKFCDQQTRYGSPTF-------------WDVSNGESGFKGPKSSQNKQGGKG 1450
                    ::|.|  ||.:    |...|             |::       |||....:.
Mouse   646 YTIHFIEEMMPEN--FCVK----GLELFSLFLFRDILELYDWNL-------KGPLFEDSP----- 692

  Fly  1451 KAKGPAKPTFNYY--------DSDNSLGSSYD--------------DDDNAGPLNYMHHNYSSDD 1493
                |..|.|::.        |....:.|.:.              :::.|..|.:....:....
Mouse   693 ----PCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYA 753

  Fly  1494 DDVADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHED 1558
            ::.     .|.|......:..::...| :::.|....:|            |..:::.|..:
Mouse   754 EEC-----KGMIVTNPGTKPSSVRIDQ-LDREQFNPEVI------------TFPIIVHFGIR--- 797

  Fly  1559 QKEPATIRYE---------ESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSM-----M 1609
               ||.:.|.         :|..||:..:.:...:...|:|.:.:|.:|.:....|.:|     :
Mouse   798 ---PAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTV 859

  Fly  1610 ELLKQ----------------LLPYVNEDV--------LAKKLG----DRRELLLSDLVELNADW 1646
            ||..|                :||.:...:        |.|.:|    ||      .|::|....
Mouse   860 ELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDR------CLLQLAMTH 918

  Fly  1647 VARH-------EQETYNVMGCGDSFDNYNDH--HRLNLDEKQLKLQYERIEIEPPTSTKAITSAI 1702
            .:.|       :....::..||.....|.|.  |.:::.:|.:.....            |.|.:
Mouse   919 PSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLIN------------IMSRL 971

  Fly  1703 LPAGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENV 1767
                          |...|:||.|       |.|     ||||.:||:.:::..:.:||..:.::
Mouse   972 --------------GQDDPTPSRI-------NHN-----ERLEFLGDAVVEFLTSVHLYYLFPSL 1010

  Fly  1768 HEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTH 1832
            .||.|:..|:..|.|.:|           .|:|.|.               ||::.::.|..|
Mouse  1011 EEGGLATYRTAIVQNQHL-----------AMLAKKL---------------ELDRFMLYAHGP-- 1047

  Fly  1833 HWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHS 1897
                                                          |.|.:...        :|
Mouse  1048 ----------------------------------------------DLCRESDL--------RH- 1057

  Fly  1898 IPDKSIADCVEALIGAYLIECGPR------GALLF------MAWLGVRVLPITRQLDGGNQEQRI 1950
                ::|:|.||||||..:|....      |.|||      ..||...:.|:..|
Mouse  1058 ----AMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQ---------- 1108

  Fly  1951 PGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMT 2015
                :||.:.             .|:..:|        :|....||||::|..|.....|.:|.|
Mouse  1109 ----EPNTDR-------------QLIETSP--------VLQKLTEFEEAIGVIFTHVRLLARAFT 1148

  Fly  2016 HASYTPNRLTDCY-QRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRH 2079
            ..:...|.||..: ||:|||||:::..:.|.:|:.....|..|.||.|||:||||...|.:|...
Mouse  1149 LRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEEL 1213

  Fly  2080 GFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGA 2144
            |..::     ...||...|.|.::                           .|.|.|:.||...|
Mouse  1214 GMQEY-----AITNDKTKRPVALR---------------------------TKTLADLLESFIAA 1246

  Fly  2145 IFLDSNMSLDVVWHVYSNM-MSPEIEQF----SNSVPKSPIRE-LLEL-----EPETAKFGKPEK 2198
            :::|.:  |:.| |.:.|: ..|.:::|    ..:.|||.::: .|.|     ||:...:...:.
Mouse  1247 LYIDKD--LEYV-HTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQT 1308

  Fly  2199 LADGRRVRVTVDVFCKGTFRGIGRNYRI--AKCTAAKCALRQ 2238
            :........||.|:.||...|.|:...|  |:..||..||.:
Mouse  1309 VGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEK 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209	22/113 (19%)
		RIBOc	1724..1930	CDD:238333	42/217 (19%)
		RIBOc	2008..2172	CDD:238333	46/169 (27%)
		DSRM_DICER	2177..2240	CDD:380680	19/70 (27%)
Drosha	XP_006520084.1	PRP38_assoc	<231..300	CDD:372353	2/4 (50%)
		RIBOc	978..1098	CDD:238333	43/218 (20%)
		rnc	1124..1352	CDD:234633	72/262 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810