Protein Alignment Dcr-1 and LOC1280401

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: XP_061515945.1
• Gene: LOC1280401 / 1280401
• VectorBaseID: AGAMI1_004892
• Length: 1696
• Species: Anopheles gambiae
• Alignment Length: 2321
• Identity: 546/2321 - (23%)
• Similarity: 875/2321 - (37%)
• Gaps: 736/2321 - (31%)

  Fly    15 FTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRARR--H--GRVSVYLSCEVGTS 75
            |.||::||::......:||||.|...|.|.:|||.:::|:|.:.|.  |  |:.:.:|:..|..:
Mosquito    15 FAPRNYQVQMKEICLAKNTIIFLPTGSGKTYIALMVMKEISHQLRNTVHEGGKRTFFLANTVALA 79

  Fly    76 TEPCSI------YTMLTHLTDLRV-------WQEQPDMQIPFDHCWTDYHVSILRPEGFLYLLET 127
            .:....      :.:..:.:::.|       |.|:          :::..|.|...:..|.:|..
Mosquito    80 KQQAQFFARHMPFNVRLYTSEVNVDAWKSDRWHEE----------FSEGQVIICTAQILLDVLRH 134

  Fly   128 RELLLSSVELIVLEDCHDSAVYQRIRPLFENHIMPAPPADRPRILGLAGPLHSAGCELQQLSAML 192
            ..:..:::.|||.::|| .||.|.........|:.||.::|||:|||:|.|...  ||:..|.:.
Mosquito   135 GYMSPANINLIVFDECH-RAVGQHPMHAIMKEIVAAPASERPRVLGLSGTLLFK--ELKMASQVP 196

  Fly   193 ATLEQ------SVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHKSFLLD 251
            ..||:      |.:..:....|..||..:.:.|:|.:|..:...:..:.||
Mosquito   197 DELERLENTFSSTIATVANYDDYATVASFSTNPNEVLVTYSKPAVHLMPLV-------------- 247

  Fly   252 HRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLL-VVLHEMGPWCTQRAAHHFYQCNEKLKVK 315
                 .|::              |::|..  :..|| |.|.|.....|:.....|.:..:::|..
Mosquito   248 -----KEMW--------------PRIDAF--VEWLLQVYLPEYSTQSTRTLQKSFCKPLKEVKRA 291

  Fly   316 TPHERHYL----LYC---LVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRLLQTLR 373
            ....:|.|    :|.   .:...::||                    .:.:..||
Mosquito   292 LTEFKHQLEEHGMYAGSLAILAVIVQL--------------------EVSKRQSP---------- 326

  Fly   374 CFKPEEVHTQADGL-RRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTETRALVATLEQILHTT 437
            |.|..:|:..|... ..:||::.:| .:.|..|.:......||       .|.|:..||....|.
Mosquito   327 CDKARQVYRSAISFCESIRHELVEA-MSGLRGTHQILSFSSDQ-------ARKLLKYLEDSYRTA 383

  Fly   438 EDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDTLCALIYCNQN 502
            ||:...                                                   ||::..:.
Mosquito   384 EDKNKQ---------------------------------------------------ALVFVKRR 397

  Fly   503 HTARVLFELLAE----ISRRDPDLKFLRCQYTTDRVADPTTEP-----KEAELEH--------RR 550
            .||:||:.|:..    :|:||.:          |.:.:|..:|     ..|.||.        |.
Mosquito   398 FTAKVLYHLIRIYFHCLSKRDNE----------DELVEPIVKPDFIVGANAALEESIDAILVVRE 452

  Fly   551 QEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVA 615
            ...|::.||....|||..|:|||||||:..||:|:.:|.|.:|.|::|.|||||...:.::::
Mosquito   453 DRRVIENFRKRKINVLCATNVLEEGIDLQMCNMVIMYDAPLSYASFMQSKGRARMKTSTYLMM-- 515

  Fly   616 PSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVF 680
                :|.|...|...|...|
Mosquito   516 ----TPAVDLQQFAKRMKLY--------------------------------------------- 531

  Fly   681 SKQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPE 745
                        ::|::.|           .:|.|..:...|                    ||.
Mosquito   532 ------------RDIENRL-----------KEELVGKTINRP--------------------EPL 553

  Fly   746 DTSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRP 810
            : :|...|:         ..||:                     ||               .|.|
Mosquito   554 E-NDVRKEL---------LDDLI---------------------PP---------------FYTP 572

  Fly   811 KPHLLTGASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTLRLPINSPLKH 875
                 ..|.:|..|||.|:|:||..:|.|.||.....|.  |.:|:...:. .|::||:.|.::.
Mosquito   573 -----FKAKLDALSAIQLLNRYCMSMPRDLFTGSNVTWE--RIDRSPTEII-VTVKLPLQSTVRE 629

  Fly   876 DIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQL 940
            .|.|..|....||::.||..||..|..:|||:..|.||..:.           ::|...||..:|
Mosquito   630 VIHGQTMKNLKLAKQSAAFNACKRLFEVGELNMYLLPIATKD-----------KVEELSEQYFKL 683

  Fly   941 ----SDEPRP---GTTKRRQYYYKRIASEFCDCRPVA-GAPCYLYFIQLTLQCPIPEE-QNTR-G 995
                ||||.|   ||.|..:.:......|...|.|.| |..||:|.:::......... :|.| .
Mosquito   684 WRKMSDEPNPKQAGTMKYVRGHKIVYPEETVGCTPQADGEQCYVYIVRMRAHFDANTHLENVRIF 748

  Fly   996 RKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILT----SEQIVCINGFL 1056
            :::|   .:...|||||.||:|:|:...:|...|.:.|  |:..|.|.:|    |.::..:..|.
Mosquito   749 QELY---SSANNFGILTRKRLPRLARMKLFVTLGAIGV--EIVPEPVCITLAPDSGELQRLKRFH 808

  Fly  1057 NYTFTNVLRLQKFLMLFDPDSTENCVFIVPTVKAPAGGKHIDWQFL---ELIQANGNTMPRAVPD 1118
            ...|.::|::.|...:.|....||...|||.:::    :.|||:.:   ..::....|..||
Mosquito   809 LLLFRDLLKVWKPFTVLDALPEENGFLIVPMLRS----QSIDWELMGKFPYLRPAAETSTRA--- 866

  Fly  1119 EERQAQPFDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVK-YGL 1182
              ||...|:.:::...||.|||:| |..|.:.|..:...|.|.|.||...|.:::.|:..: :.:
Mosquito   867 --RQHLRFETEQYLLRVVHPWYKN-DPDQNYVVVRVRDDLRPTSPFPNAKYDSYEQYFAQEHHQV 928

  Fly  1183 TIQNTSQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPF 1247
            .:::..|.|::|...:..||.|.|          ...::.....:....|.::||:|||.....|
Mosquito   929 VVRHEDQFLIEVKGITTSLNRLHP----------GAEADGGASTRSRYWEFQEILIPELVHNFEF 983

  Fly  1248 PASLWRTAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKS 1312
            ||..|..|..||..|:|::.||||:.||..::.:..:|.:..|
Mosquito   984 PADYWLKATLLPSALHRVHYLLLAEGIRVDLARNAQVGSEHCE---------------------- 1026

  Fly  1313 RESKQKESLKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIE 1377
                    ..:|.|..:.|:...:|.|:                     :..||:     ||
Mosquito  1027 --------RVEDVIIDRVLSIEHQKSTA---------------------LYGGED-----DD--- 1054

  Fly  1378 IGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKG---- 1438
                     ||     :||:|||:.                         :..:.|.|.:.
Mosquito  1055 ---------DD-----EEDEDEDEE-------------------------EKDSDEEGARSMQVA 1080

  Fly  1439 ------PKSSQNKQGGKGKAKGPAKPTFNYYDSDN-SLGS--SYDDDDNAGPLNYMHHNYSSDDD 1494
                  ||....||         .....|...||: ||..  .|..::|..|.: :..|:
Mosquito  1081 CRTAVDPKQPSGKQ---------LLQVLNQIHSDSISLADRVQYPWEENEQPKD-LERNW----- 1130

  Fly  1495 DVADDIDAGRIA-FTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNF-KHE 1557
            |....||....| |..|.|.:.:....:|.:.      :..||.:        .:|...|. |:|
Mosquito  1131 DTVSKIDIDYYASFVKKYEQQAVTIVTDVNRS------VTETNID--------RMLANLNMNKNE 1181

  Fly  1558 DQKEPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNED 1622
            .:..|         .|....:|.|                  ...||:::|:
Mosquito  1182 AEASP---------VKALPALEDG------------------HGPVAQIAML------------- 1206

  Fly  1623 VLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERI 1687
                                                             ||.:|.
Mosquito  1207 -------------------------------------------------RLTMDN---------- 1212

  Fly  1688 EIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFL 1752
                 |:..|:            :|.||           |||||..::.|..||||.|.:||:||
Mosquito  1213 -----TANVAL------------QQSDL-----------LQALTTKSSADVFNLERFEVLGDAFL 1249

  Fly  1753 KYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVP 1817
            |:|::.|:...:.:.|||.|:..:.:.|:|.||........|...:.|..|:|.::|:||...||
Mosquito  1250 KFAVSVYILFRHTSWHEGYLTTCKGRMVSNRNLLYCAMGYGLPGKIKAHPFDPKNDWVPPLSTVP 1314

  Fly  1818 KELEKALIEA-KIPT--HHWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSND 1879
            ..:.:|:::| :.|.  ::.||.:    :.:.|..:.:...:|...| :||........|
Mosquito  1315 GAVRRAMVDANESPALLYNLKLTE----EEIQSGVVAQATVDKFLPL-IEQAPAPSQSTL----- 1369

  Fly  1880 SCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGG 1944
                      :.::.|..|.||.:||..|||:|..:...|...:..|::.||:
Mosquito  1370 ----------HTVLQQVQIRDKVVADVTEALLGVCVKTVGYERSFRFLSHLGI------------ 1412

  Fly  1945 NQEQRIP-GSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRS 2008
                 || |:..|......|.         |:..:.| ...::||||...|..|.:|||:||:|:
Mosquito  1413 -----IPKGADVPMLLRTTTF---------PIGDYFP-VRHKVDQLLCNPERIEATLGYRFRNRT 1462

  Fly  2009 YLLQAMTHASYTPNRLTDCYQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFA 2073
            |||||.||.|||.|.||..||:||||||||||:|::.::||.....|||.|||||||||||...|
Mosquito  1463 YLLQAFTHTSYTSNSLTGSYQQLEFLGDAVLDFLVSMYIYERNPSMSPGQLTDLRSALVNNVNLA 1527

  Fly  2074 SLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSEE-ECDDAEDVEVPKALGDV 2137
            .:.||:..|:.....||.|.|.|.:||.:.:.:.:..|....||:|| :...||.|:|||.||||
Mosquito  1528 CVLVRNELHRHILSQSPMLTDAIGKFVAVHRCHRNQGSNWVRLLTEESDTPMAEYVDVPKVLGDV 1592

  Fly  2138 FESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQFSNSVPKSPIRELLELEPE-----TAKFGKPE 2197
            .|::.|||:|||...|...|.|...::..||..|:...|...:|:|.| .||     :|.|.:.|
Mosquito  1593 LEALIGAIYLDSGNDLVATWEVCFRLLRDEIADFTRKTPIQVVRQLYE-HPEASPHFSAPFVEEE 1656

  Fly  2198 ----KLADGRRVRVTVDVFCKGTFRGIGRNYRIAKCTAAKCALRQL 2239
                ||:...|.:       :.|..|.|:|...||..|||.||.::
Mosquito  1657 VVYVKLSYTHRSQ-------RQTVYGFGKNKDDAKRAAAKIALSKI 1695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	54/215 (25%)
		Dicer_PBD	240..344	CDD:277191	16/111 (14%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	44/140 (31%)
		Dicer_dimer	825..916	CDD:460900	33/90 (37%)
		PAZ_dicer_like	1091..1212	CDD:239209	32/124 (26%)
		RIBOc	1724..1930	CDD:238333	58/208 (28%)
		RIBOc	2008..2172	CDD:238333	80/164 (49%)
		DSRM_DICER	2177..2240	CDD:380680	22/72 (31%)
LOC1280401	XP_061515945.1	None