Protein Alignment Dcr-1 and drosha

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: XP_061514326.1
• Gene: drosha / 1277864
• VectorBaseID: AGAMI1_003769
• Length: 1500
• Species: Anopheles gambiae
• Alignment Length: 1805
• Identity: 311/1805 - (17%)
• Similarity: 513/1805 - (28%)
• Gaps: 815/1805 - (45%)

  Fly   575 GIDVPKCNL--------VVRWDPPTTY-------RSYVQCKGRARAAPAYHVI-LVAPSYKSPTV 623
            |..:|..|.        :.|..||..|       ||:....|...::...|.. ...|.||.  .
Mosquito    46 GFTMPNFNFPPPSLPPAMTRPPPPAPYYARERPERSHSPNTGSYHSSSQQHAYKRHPPPYKG--T 108

  Fly   624 GSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPY-----TFGTA-RGTVKILNPEVFSK 682
            |..|...:..||          .|.|::....|:||...|     ::.:| ..|.....|...|:
Mosquito   109 GGSQYPPQGRRY----------GSPSNNPVPSNTSGGTGYKHPGHSYSSAGHKTASYTRPSAPSR 163

  Fly   683 QPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSR--------------- 732
            ..|:.....:....|.|....:.|.| :|....|.||:|.||.::.:.||
Mosquito   164 YAPSGRSHSVPSNTDRLGRPPRTDRS-ASCRRDSDSNSSSSERASSRHSRFKVDTERAEILSKWC 227

  Fly   733 RFQCELSSLTEPEDTSDTTAEI----DTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQ 793
            |..||.|     ||.:...||:    |....:.|:..:|.::....:.:|.........|...|:
Mosquito   228 RNYCETS-----EDIARKLAEMANDEDRTLWVRSSPAELYYKRVSDKVVESTARLDALCTLFEEE 287

  Fly   794 EQSEAERFSACLAAYRPKP-----------HLLTGASVDLGSAIALVNKYCARLPSDTFTKLTA- 846
            ....|||..|....|.|.|           |....:|.:...........|      :..:|||
Mosquito   288 LIKRAERIRATQTPYNPPPRKRKMKMCRHKHDKCSSSSESSDEEMEFEDEC------SMEELTAK 346

  Fly   847 ----------LW-------------RCT-RNERAGVTLFQYTLRLPINSPLKHDIVGLPMPTQTL 887
                      ||             ||: |:.|.|:...:|.
Mosquito   347 IKHPLRLHVDLWYNDPGEMNDGPLCRCSARSRRTGIRHGKYP----------------------- 388

  Fly   888 ARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLSDEPRPGTTKRR 952
                                      |:|||                         |:
Mosquito   389 --------------------------GEEGF-------------------------PK------- 395

  Fly   953 QYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCP----------IPEEQNTRGRKIYPPEDAQQG 1007
                         |.|.:.....||..::|:..|          |..:|:         |...:|
Mosquito   396 -------------CIPNSNNADKLYHYRITISPPTNFLTKTPTIIKHDQH---------EFLFEG 438

  Fly  1008 FGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKFLML 1072
            |.:|..:.|.:|....:      ::.::|..   ::...||:.     .|:|.       :.|.|
Mosquito   439 FSLLAHEPIGELPTCKV------IRFNIEYT---ILYIEEQMP-----ENFTI-------RELNL 482

  Fly  1073 FDPDSTENCVFIVPTVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQPFDPQRFQDAVVM 1137
            ||                    :::..:.|||:                           |..|.
Mosquito   483 FD--------------------RYLFRELLELV---------------------------DFTVQ 500

  Fly  1138 PWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSARLN 1202
            |....:|..        ||      |:                                     :
Mosquito   501 PSGSGEDSS--------CP------CY-------------------------------------H 514

  Fly  1203 FLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPCILYRING 1267
            || ||:|.    .||.:.:|.       |...::|                      ..|...:|
Mosquito   515 FL-PRFVR----DLPDNGKEV-------LAMSEVL----------------------RYLLDNSG 545

  Fly  1268 LLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKESLKDDTINGKDLA 1332
            .|:..|:.|::     :...|.|.:|:.                            |.:.|..::
Mosquito   546 PLVPPDMLKEM-----MDMSQNEWQDYV----------------------------DYVKGMVVS 577

  Fly  1333 DVEKKPTSEET-QLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWSNDMADDIASFNQED 1396
            :...||.|... |||: :..|..|.:||
Mosquito   578 NPGMKPCSVRVDQLDR-NVGDVPEANAI------------------------------------- 604

  Fly  1397 DDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPA-KPTF 1460
             ||:...|    |..|.|                    |.:.|:.|.        |..|. :..:
Mosquito   605 -DENGLVH----PVIVHF--------------------GIRPPQLSY--------AGNPEYQKAW 636

  Fly  1461 NYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKR 1525
            ..|                  :.:.|                 .||..||   .:.|..:::|.:
Mosquito   637 REY------------------IKFRH-----------------LIANMSK---PSFEDKRKLEAK 663

  Fly  1526 QKQLSIIQATNANERQYQQTKNLLIGFNFK--HEDQKEPATIRYEESIAKLKTEIESGGMLVP-- 1586
            :.:|..::      .|.:..:|:.|..:.|  |.              ..:..::....||:|
Mosquito   664 ENRLLEMR------MQGRMKRNITIAVSAKAFHR--------------TGIMCDMVQHAMLIPVL 708

  Fly  1587 --HDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLS-------DLVEL 1642
              |   |...||            :.:|::.:.|.        ..:|..|.|:       :....
Mosquito   709 TGH---LRFHRS------------LNVLERYIGYT--------FTNRYTLQLALTHPSYKENFGT 750

  Fly  1643 NADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAI-LPAG 1706
            |.|    |.:.  ::..||.....|.|.          |:.|..      |..:.|.:.| :.:.
Mosquito   751 NPD----HARN--SLTNCGIRQPEYGDR----------KIHYMN------TRKRGINTLISIMSR 793

  Fly  1707 FSFDRQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGK 1771
            |..:.:.|                  ||....   ||||.:||:.:::..:.:|:..:.::.||.
Mosquito   794 FGKEHETD------------------SNITHN---ERLEFLGDAVVEFITSIHLFHMFPDLEEGG 837

  Fly  1772 LSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKL 1836
            |:..|:..|.|.:|..|.::..|.|:|:..
Mosquito   838 LATYRAAIVQNQHLAVLAKKLHLEEFMLYA----------------------------------- 867

  Fly  1837 ADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDK 1901
                                                   ..:|.|::        |..:|
Mosquito   868 ---------------------------------------HGSDLCHE--------LELRH----- 880

  Fly  1902 SIADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVV---- 1962
            ::|:|.|||:||.|                         ||||.:.          |:.|.
Mosquito   881 ALANCFEALMGALL-------------------------LDGGIEV----------ADRVFAYAL 910

  Fly  1963 -----TVYGAWPT-PRSPLLHFAP-NATEELD--QLLSGFEEFEESLGYKFRDRSYLLQAMTHAS 2018
                 |:.|.|.. |..||....| .....:|  ::|.....||:|:|.:|.....|.:|.|..|
Mosquito   911 FQEDDTLRGIWVNYPSHPLQEQEPLGDRHHIDSFEMLKTLTRFEDSIGVQFNHIRLLARAFTDRS 975

  Fly  2019 YTPNRLT-DCYQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFH 2082
            .....|| ...||||||||.||..:.:.:||....:|..|.|:.|||:||||...|.:....|..
Mosquito   976 IGFTNLTLGSNQRLEFLGDTVLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMT 1040

  Fly  2083 KFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFL 2147
            ::..:.:|                                  ..|::. |...|:.|:..||:::
Mosquito  1041 QYAVYSNP----------------------------------KADLKT-KDRADLLEAFLGALYV 1070

  Fly  2148 DSNMS-LDVVWHVYSNMMSPEIEQFSNSV----PKSPIRELLELEPETAKFGKPEKLADGRRVRV 2207
            |..:. .::..||   .:.|.::.|..:.    |||.:::.. |...|...|:|:       :.|
Mosquito  1071 DKGLEYCEMFCHV---CLFPRLQDFIMNQDWNDPKSKLQQCC-LTLRTMDGGEPD-------IPV 1124

  Fly  2208 TVDVFCKGT-----------FRG------IGRNYRIAKCTAAKCALRQLK 2240
            ...:.|.|.           |||      .|.:.:.|:..|||.||...|
Mosquito  1125 YKVIECTGPTNTRVYSVAVYFRGKRLACADGHSIQQAEMNAAKQALENSK 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120
		Dicer_PBD	240..344	CDD:277191
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	11/54 (20%)
		Dicer_dimer	825..916	CDD:460900	13/115 (11%)
		PAZ_dicer_like	1091..1212	CDD:239209	15/120 (13%)
		RIBOc	1724..1930	CDD:238333	32/205 (16%)
		RIBOc	2008..2172	CDD:238333	41/165 (25%)
		DSRM_DICER	2177..2240	CDD:380680	19/79 (24%)
drosha	XP_061514326.1	None