Protein Alignment Dcr-1 and dicer1

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: NP_001123390.2
• Gene: dicer1 / 100170154
• XenbaseID: XB-GENE-491114
• Length: 1893
• Species: Xenopus tropicalis
• Alignment Length: 2396
• Identity: 771/2396 - (32%)
• Similarity: 1095/2396 - (45%)
• Gaps: 693/2396 - (28%)

  Fly     5 WCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR----RHGRVS 65
            |....:|..::|||.:|||||..|.:.|||:||...|.|.|||:.|.:|||.:.|    ::.:.:
 Frog    22 WQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNSGSGKTFIAVLLSKELSYQIRGDFSKNTKRT 86

  Fly    66 VYL-SCEVGTSTEPCSIYTMLTHLTDLRV--WQEQPDMQIPFDHCWT---------DYHVSILRP 118
            |:| :.|...|.:   :..:.|| |||:|  :.:|...|     ||.         .:.|.::..
 Frog    87 VFLVNSEKQVSQQ---VSAVRTH-TDLKVGEYSDQEKTQ-----CWAKERWYLEFETHQVLVMTC 142

  Fly   119 EGFLYLLETRELLLSSVELIVLEDCH---DSAVYQRIRPLFENHIMPAPPADRPRILGLAGPLHS 180
            ..||.:|::..:.||::.|:|.::||   ....|:.|..:.|:    ..|.  ||||||...:.:
 Frog   143 HIFLNVLKSGNVSLSNINLLVFDECHLAIQDHPYREIMKICES----CQPC--PRILGLTASILN 201

  Fly   181 AGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLV--LADVLN 243
            ..|:.:.|...:..||:.:....|||:|:|.:.||.|:|.|.::.|.|: :|:..|.  |.:.|:
 Frog   202 GKCDPRDLEEKIQKLEEILRSNAETATDLVVLDRYASQPCEIVLDCGPY-IDKSGLYQRLLNELD 265

  Fly   244 THKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAHHFYQC 308
            ...:||:|.....:.           |: .|..:....:::....||..:||||..:.|....:
 Frog   266 EALNFLIDCNISTHS-----------KE-RDSTLISKQILSDCQTVLLVLGPWCADKVAGMMVR- 317

  Fly   309 NEKLKVKTPHE-----RHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIE-RYSSPKVRR 367
              :|:....||     |.:||:  ..|.|.::::|||..|         |..::: ::.:|||.:
 Frog   318 --ELQKYIKHEQEELHRKFLLF--TDTILRKIHALCEEHF---------SPASLDMKFVTPKVIK 369

  Fly   368 LLQTLRCFKPEEVHTQADGLRRMRHQVDQADF--NRLSHTLESKCRMVDQMDQPPTETRALVATL 430
            ||:.||.:||.|           |.|.:..::  ||......|.....|..|
 Frog   370 LLEILRKYKPYE-----------RQQFESVEWYNNRNQDNYVSWSDSEDDDD------------- 410

  Fly   431 EQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDTLCA 495
                   ||.:........|..|:|.                                 ::.||.
 Frog   411 -------EDEEIEEKEKTETSFPSPF---------------------------------TNILCG 435

  Fly   496 LIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAELEHRRQEEVLKRFR 559
            :|:..:.:||.||..|:.|..::||:|.::...:.|.. :.......|:.|:|.|:|||||::||
 Frog   436 IIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFR 500

  Fly   560 MHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSYKSPTVG 624
            .|:.|:||.||::|||:|:||||||||:|.|:.||||||.||||||..:.:::|
 Frog   501 AHETNLLIATSIVEEGVDIPKCNLVVRFDLPSEYRSYVQSKGRARAPISNYIML----------- 554

  Fly   625 SVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQPPTACD 689
                                ||||
 Frog   555 --------------------ADSD----------------------------------------- 558

  Fly   690 IKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTSDTTAEI 754
             |::..:::|..
 Frog   559 -KIKAFEEDLKT----------------------------------------------------- 569

  Fly   755 DTAHSLASTTKDLVHQMAQYREIEQMLLSKCA------NTEPPEQEQSEAERFSACLAAYRPKPH 813
                               |:.||::|.:||:      ||| .|....:.|.|         .|:
 Frog   570 -------------------YKAIEKILRNKCSKSIDCGNTE-SEPIVDDDEIF---------PPY 605

  Fly   814 LLT----GASVDLGSAIALVNKYCARLPSDTFTKLTALWRC-TRNERAGVTLFQYTLRLPINSPL 873
            :|.    ...|.:.:||..:|:||||||||.||.|..  :| ||....|  |::.||.|||||||
 Frog   606 VLRQDDGSPRVTINTAIGHINRYCARLPSDPFTHLAP--KCKTREFPDG--LYRSTLYLPINSPL 666

  Fly   874 KHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIV 938
            :..|||.||....||.|..||..|.:||.||||||.|.|:|||..:..|      ||:..||:
 Frog   667 RAPIVGPPMNCGRLADRAVALICCKKLHEIGELDDHLMPVGKETVKYEE------ELDLHDEE-- 723

  Fly   939 QLSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPED 1003
            :.|...|||:|||||.|.|.|.....:..|..|.|||||.|.:.|..|:|:|.|.|.||:|||||
 Frog   724 ETSVPGRPGSTKRRQCYPKAIPECLRNSYPKPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPED 788

  Fly  1004 AQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQK 1068
            ..:.|||||.|.||::..|.::||||||.:|:||.|....|..||:..|.....|.|:::|||:|
 Frog   789 TTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLNLEQLELITRLHQYIFSHILRLEK 853

  Fly  1069 FLMLFDPDSTENCVFIVP-TVKAPAGGKHIDWQFLELIQ-ANGNTMPRAVPDEERQAQP---FDP 1128
            ..:.|.|...:....::| .|...:|...||::|:|.|: :...|   .:|:.:..|:.   |..
 Frog   854 PALEFKPTVADCAYCVLPLNVVNDSGTLDIDFKFVEDIEKSEART---GIPNTQYSAESPFIFKL 915

  Fly  1129 QRFQDAVVMP---WYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQP 1190
            :.:||||::|   .|||.|||..||||::...|:|||.||...|.||..||..||.|.:.|.:||
 Frog   916 EDYQDAVIIPRQVIYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQP 980

  Fly  1191 LLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTA 1255
            ||||||||:|||.||||::|:||.|||.||.|.::||.|:|:.|||||||||.:||.||||||.|
 Frog   981 LLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPVPASLWRKA 1045

  Fly  1256 VCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKES 1320
            ||||.||||::.||.|:::|.|.:.|.|:|.:.:.| ||.:|.|||||      |:|.:||
 Frog  1046 VCLPSILYRLHCLLTAEELRAQTAIDAGVGVKSLPD-DFRYPNLDFGW------KRSIDSK---- 1099

  Fly  1321 LKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWSNDM 1385
               ..|:.:..:.||   :..:.:|:|.:..|....||...:|           :::|
 Frog  1100 ---TFISNQSSSSVE---SESDCRLNKTTAPDSAASSAANSVI-----------YMQI------- 1140

  Fly  1386 ADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQGGKG 1450
             :|..|.|.....:....||    ..|.|.|........:...::||
 Frog  1141 -NDQMSVNCTPPCQKSLSHL----QTVCFSDDYKAINGISCNGLTNG------------------ 1182

  Fly  1451 KAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNEAET 1515
                                                            |.:|...|...|:|..|
 Frog  1183 ------------------------------------------------DWEAESAACFQKDERIT 1199

  Fly  1516 IETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTEIES 1580
            .:  ||:.::.....:              :||
 Frog  1200 CK--QEIPEKSTSFHV--------------QNL-------------------------------- 1216

  Fly  1581 GGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNAD 1645
                 |.:.|.:||....:.                   ::..::|...|......:..:..::.
 Frog  1217 -----PKENQPILKECTLSN-------------------SDGNVSKPTSDECPSTCTSDMHYDSG 1257

  Fly  1646 WVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFD 1710
            ...||..:|.
 Frog  1258 LSNRHSSKTL------------------------------------------------------- 1267

  Fly  1711 RQPDLVGHPGPSPSIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHL 1775
                     ||:|.:||||||:|||:||.||||||.:||||||:||||||:.||.:.|||:||::
 Frog  1268 ---------GPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYM 1323

  Fly  1776 RSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYV------------------------ 1816
            |||:|:|.||||||::|.....|:.:.|:|..|||||.|.|
 Frog  1324 RSKKVSNCNLYRLGKKKGSPSRMVVSIFDPPVNWLPPGYIVNQDKNSDKWESNETSGEDVMVNGK 1388

  Fly  1817 -----------------PKE------------------LEKALIEA-----KIP---------TH 1832
                             |||                  ::..|:.:     |||         .:
 Frog  1389 IDEDFDDEEDEDLMWRNPKEETDFDDDFLEYDQEHIKFIDSMLMGSGAFVKKIPLSSFAPPDQNY 1453

  Fly  1833 HWKL------------ADLLDIKNLSSVQIC-----EMVREKADALGL----EQNGGAQNGQLDD 1876
            .|:.            .|..|....|...:|     :.|.|....:|.    |:|.||..|:..
 Frog  1454 EWRAPKKPPLESSQFPCDFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGADAGKQS- 1517

  Fly  1877 SNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGALLFMAWLGVRVLPITRQL 1941
                       |.|:|.::..|.|||||||||||:|.||..||.|.|.||:..||::|||..|:|
 Frog  1518 -----------ISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPEVRKL 1571

  Fly  1942 DGG----NQEQRIPGSTKPNAENVVTV-----------YGAWP-TPRSPLLHFAPNATEELDQLL 1990
            ...    :.......||:.|.......           ||... .||....|  |:|.:.||.|:
 Frog  1572 VTNTNVISASSSYQNSTRDNCTLTARTNTDLSSCKGIDYGYLKIPPRCMFEH--PDAEKTLDHLI 1634

  Fly  1991 SGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLGDAVLDYLITRHLYEDPRQHS 2055
            ||||.||:.:.|.|::::|||||.|||||..|.:|||||||||||||:||||||:||||||||||
 Frog  1635 SGFENFEKKINYPFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHS 1699

  Fly  2056 PGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYL-LSE 2119
            ||.|||||||||||||||||||::.:||:|:.:||.|..|||.||:.|.|.......:..| .||
 Frog  1700 PGVLTDLRSALVNNTIFASLAVKYDYHKYFKAISPELFHVIDDFVQFQLEKNEMQGMDSELRRSE 1764

  Fly  2120 EECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQFSNSVPKSPIRELL 2184
            |:.:..||:|||||:||:|||:||||::||.|||:.|||||..||.|.||:||.:||:||:||||
 Frog  1765 EDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWHVYYPMMQPLIEKFSANVPRSPVRELL 1829

  Fly  2185 ELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRIAKCTAAKCALRQLK 2240
            |:|||||||...|:..|| :|||||:|..||.|:|:||:|||||..||:.|||.||
 Frog  1830 EMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLK 1884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	65/211 (31%)
		Dicer_PBD	240..344	CDD:277191	24/108 (22%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	56/124 (45%)
		Dicer_dimer	825..916	CDD:460900	50/91 (55%)
		PAZ_dicer_like	1091..1212	CDD:239209	58/127 (46%)
		RIBOc	1724..1930	CDD:238333	102/299 (34%)
		RIBOc	2008..2172	CDD:238333	109/164 (66%)
		DSRM_DICER	2177..2240	CDD:380680	39/62 (63%)
dicer1	NP_001123390.2	DEXHc_dicer	32..229	CDD:350792	65/211 (31%)
		DECH box	165..168		0/2 (0%)
		Dicer_PBD	261..355	CDD:277191	25/119 (21%)
		SF2_C_dicer	360..555	CDD:350189	79/289 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..424		5/43 (12%)
		Dicer_dimer	621..709	CDD:460900	50/91 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..737		8/20 (40%)
		PAZ_dicer_like	877..1002	CDD:239209	58/127 (46%)
		RIBOc	1273..>1364	CDD:197778	57/90 (63%)
		RIBOc	1653..1817	CDD:238333	109/163 (67%)
		DSRM_DICER	1822..1884	CDD:380680	39/62 (63%)