Protein Alignment Dcr-1 and drosha

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: NP_001107152.1
• Gene: drosha / 100135003
• XenbaseID: XB-GENE-494685
• Length: 1325
• Species: Xenopus tropicalis
• Alignment Length: 1251
• Identity: 238/1251 - (19%)
• Similarity: 405/1251 - (32%)
• Gaps: 462/1251 - (36%)

  Fly  1196 HTSARLNFLTPRYVNRKGVALPTSSEETKRAK----RENLEQKQILVPELCTVHPFPASLWRTAV 1256
            |..:|.:..|.|...::..:...||.|.||::    .|:|.:..             ::..::::
 Frog   290 HRESRRSTSTERSYRKRPKSPSPSSREHKRSRWEEDNESLSESS-------------SAKEKSSI 341

  Fly  1257 CLPCILYRINGLLLADDIRKQVSADLG-LGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKES 1320
                            ..:::.|.|.. |.|.:.|||:...|:    |......:....|...:.
 Frog   342 ----------------SFKEKDSLDENLLERNEEEDEELLKPV----WVRCTHSESYYTSDPMDQ 386

  Fly  1321 LKDDTING----KDLADV-------------EKKPTSE--ETQLDKD---SKDDKVE-------- 1355
            :.|.|:.|    :||.|.             ..:|..|  :|:||:|   |.|.:.|
 Frog   387 VGDSTVVGTSRLRDLYDKFEEELGKRQATARAARPAWEPPKTKLDEDLESSSDSECETDDSCSSS 451

  Fly  1356 --KSAIELIIEGEEKLQEADDFIEIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQ 1418
              ....::|.|.:.|....|...| ..|.||.       .|.:|.       |:...::|.....
 Frog   452 SDSEVFDVIAEIKRKKAHPDRLHE-ELWYNDP-------GQMNDG-------PLCKCSLKARRTG 501

  Fly  1419 TRYGSPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDD------ 1477
            .|:      .:..||...|..:...|..|.....:....|..|:. :|......|||.:
 Frog   502 IRH------SIYPGEEPIKACRPMTNNAGRLFHYRITVSPPTNFL-TDRPTVIEYDDHEYIFEGF 559

  Fly  1478 ---NAGPL-NY-------------MH-----------------------------HNYSSDDDDV 1496
               :..|| |:             :|                             |:::..|..|
 Frog   560 SMFSHSPLTNFPLCKVIRFNIDYTIHFIEEMMPEHFCVKGLELFSSHLYKDILELHDWNLMDPSV 624

  Fly  1497 A-DDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATN---------ANERQYQQ------- 1544
            . :|.:..:..|..:......:..:||....:.|..:...|         ||..|:::
 Frog   625 ENNDANCPQFHFMPRFVRFLPDGGKEVLSMHQVLLYLLRCNKSLVPEEEIANMLQWEELEWQKYA 689

  Fly  1545 ---------------------------------TKNLLIGFNFKHEDQKEPATIRYE-------- 1568
                                             |..:::.|..:      ||.:.|.
 Frog   690 EECKGMIVTNPGMKPSSVRIDQLDREQFNPDVITFPIIVHFGIR------PAQLSYAGDPQYQKL 748

  Fly  1569 -ESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSM-----MELLKQ------------- 1614
             :|..||:..:.:...:...|:|.:::|.:|.:....|.:|     :||..|
 Frog   749 WKSYVKLRHLLANSPKVKQADKQKLVQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQ 813

  Fly  1615 ---LLPYVNEDV--------LAKKLGDRRELLLSD--LVELNADWVARH-------EQETYNVMG 1659
               :||.:...:        |.|.:|    .:.:|  |::|.....:.|       :....::..
 Frog   814 HAMMLPVLTHHIRYHKCLMHLDKLIG----YIFTDRCLLQLAMTHPSHHLNFGMNPDHARNSLSN 874

  Fly  1660 CGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPS 1724
            ||.....|.|.          |:.|..:.      .|.|.:.|        .....:|...|:||
 Frog   875 CGIRQPKYGDR----------KVHYMHMR------KKGINTLI--------NIMSRLGQDDPTPS 915

  Fly  1725 IILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLG 1789
            .|       |.|     ||||.:||:.:::..:.:||..:..:.||.|:..|:..|.|.:|
 Frog   916 RI-------NHN-----ERLEFLGDAVVEFLTSVHLYYLFPLLEEGGLATYRTAIVQNQHL---- 964

  Fly  1790 RRKRLGEYMIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMV 1854
                   .|:|.|.               ||::.::.|..|
 Frog   965 -------AMLAKKL---------------ELDRFMLYAHGP------------------------ 983

  Fly  1855 REKADALGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECG 1919
                                    |.|.:...        :|     ::|:|.|||:||..:|.|
 Frog   984 ------------------------DLCRESDL--------RH-----AMANCFEALMGAVYLEGG 1011

  Fly  1920 PRGALLFMAWLGVRVLPITRQLDG----GNQEQRIPGSTKPNAENVVTVYGAWPT-PRSPLLHFA 1979
                           |...:||.|    |||:.|                ..|.. |..||....
 Frog  1012 ---------------LEEAKQLFGRLLFGNQDLR----------------DVWLNYPLHPLQLQE 1045

  Fly  1980 PNATE---ELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCY-QRLEFLGDAVLD 2040
            .|:..   |...:|....:|||::|.:|.....|.:..|..:...|.||..: ||:|||||:::.
 Frog  1046 SNSDRHLIETSPVLKKLTKFEEAIGVEFTHVRLLARVFTLRTVGFNHLTLGHNQRMEFLGDSIMQ 1110

  Fly  2041 YLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQE 2105
            .:.|.:|:.....|..|.||.|||:||||...|.:|...|..:|     ...||...|.|.::
 Frog  1111 LVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEF-----AITNDKTKRPVVLR-- 1168

  Fly  2106 NGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNM-MSPEIE 2169
                                     .|.|.|:.||...|:::|.:  |:.| |.:.|: ..|.::
 Frog  1169 -------------------------TKTLADLLESFIAALYIDKD--LEYV-HTFMNVCFFPRLK 1205

  Fly  2170 QF----SNSVPKSPIRE-LLEL-----EPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNY 2224
            :|    ..:.|||.::: .|.|     ||:...:...:.:........||.|:.||...|.|:..
 Frog  1206 EFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGP 1270

  Fly  2225 RI--AKCTAAKCALRQ 2238
            .|  |:..||..||.:
 Frog  1271 SIQQAEMGAAMDALEK 1286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120
		Dicer_PBD	240..344	CDD:277191
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819
		Dicer_dimer	825..916	CDD:460900
		PAZ_dicer_like	1091..1212	CDD:239209	4/15 (27%)
		RIBOc	1724..1930	CDD:238333	38/205 (19%)
		RIBOc	2008..2172	CDD:238333	46/169 (27%)
		DSRM_DICER	2177..2240	CDD:380680	19/70 (27%)
drosha	NP_001107152.1	PHA02682	<7..>95	CDD:177464
		RIBOc	914..1024	CDD:238333	43/223 (19%)
		Rnc	1060..1288	CDD:440336	71/262 (27%)