DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and RIPK2

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_003812.1	Gene:	RIPK2 / 8767	HGNCID:	10020	Length:	540	Species:	Homo sapiens

Alignment Length:	281	Identity:	86/281 - (30%)
Similarity:	136/281 - (48%)	Gaps:	33/281 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPYEEIQTKELIGTGFYGSV---YRAVWRNREIALKRIR-----EGCEDKKIEREIYQLTKASHV 64
            :||.::.....:..|..|:|   ..|.|| .::|:|.:.     ...|.|.:.||...|.||...
Human    13 IPYHKLADLRYLSRGASGTVSSARHADWR-VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFS 76

  Fly    65 NIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSK-PSYSHAHAFNWAHQIAQGIAYLHGMQPK 128
            .|:.:.|.........::.|::..|||:..||.|:: |..:....|...|:||.|:.|||.|.|
Human    77 YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP- 140

  Fly   129 AVIHRDIKPLNTLLCEKGLKLKICDFG----TVVDLSQSISCNA----GTCRYKAPEVL---QGN 182
            .::|.|:|..|.|| :....:||.|||    .::.||||.|..:    ||..|..||..   |.:
Human   141 PLLHHDLKTQNILL-DNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKS 204

  Fly   183 KPDEKCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCPADI------VA 241
            :...|.|:||:|:..||:||||:|||......::..::::|.||.::  ....|.||      ::
Human   205 RASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVIN--EESLPYDIPHRARMIS 267

  Fly   242 LLYASW--DPDISKRFSMELI 260
            |:.:.|  :||....|...||
Human   268 LIESGWAQNPDERPSFLKCLI 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	82/271 (30%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	84/270 (31%)
RIPK2	NP_003812.1	STKc_RIP2	20..303	CDD:270928	84/274 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..369
		CARD_RIP2_CARD3	438..524	CDD:176764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4962
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950