DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and tnni3k

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001191752.1	Gene:	tnni3k / 799621	ZFINID:	ZDB-GENE-081104-399	Length:	835	Species:	Danio rerio

Alignment Length:	292	Identity:	84/292 - (28%)
Similarity:	135/292 - (46%)	Gaps:	38/292 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EIQTKELIGTGFYGSVYRAVWRNREIALKRIREGCEDKKIE-----REIYQLTKASHVNIVELYG 71
            |::..|:||:|.:|.||:...||:.:|:||.|......|.:     ||:..|.:.:|..:::..|
Zfish   462 ELEFNEIIGSGSFGKVYKGKCRNKIVAIKRYRPNTYCSKSDTDMFCREVSILCRLNHPCVIQFVG 526

  Fly    72 TSRHEGCAL-LLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGM-QPKAVIHRD 134
            ....:.... ::.::|.||||.|.|| :.|...........|..:|:|:.|||.: ||  :||||
Zfish   527 ACLDDPSQFAIVTQYVSGGSLFSLLH-EQKRIIDLQSKLIIAIDVAKGMEYLHNLTQP--IIHRD 588

  Fly   135 IKPLNTLLCEKGLKLKICDFG-----TVVDLSQSISCNAGTCRYKAPEVL-QGNKPDEKCDVYSW 193
            :...|.||.|.|..: :.|||     ..|| ..:::...|..|:.||||. |..:...|.|::|:
Zfish   589 LNSHNILLYEDGHAV-VADFGESRFLLSVD-EDNMTKQPGNLRWMAPEVFTQCTRYTVKADMFSY 651

  Fly   194 AITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCPADIVALLYASWD--PDISKRFS 256
            |:..||:|:.:.||.................||.:.   ...|..|.|||...|:  |:....||
Zfish   652 ALCLWELLTGEIPFAHLKPAAAAADMAYHHVRPPIG---YSIPKPISALLMRGWNVCPEERPEFS 713

  Fly   257 ------------MELISQSMGRILSEAGSIPP 276
                        :||:|.:..   :.:||:.|
Zfish   714 EVVAKLEECLCNVELMSPASS---NSSGSLSP 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	77/270 (29%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	79/275 (29%)
tnni3k	NP_001191752.1	ANK	<56..121	CDD:238125
		Ank_4	67..121	CDD:290365
		ANK repeat	67..98	CDD:293786
		ANK	99..220	CDD:238125
		ANK repeat	100..131	CDD:293786
		Ank_2	105..195	CDD:289560
		ANK repeat	136..164	CDD:293786
		ANK	161..290	CDD:238125
		ANK repeat	166..197	CDD:293786
		Ank_2	171..261	CDD:289560
		ANK repeat	199..232	CDD:293786
		ANK	229..360	CDD:238125
		ANK repeat	269..302	CDD:293786
		Ank_2	274..369	CDD:289560
		ANK repeat	304..337	CDD:293786
		ANK	334..>401	CDD:238125
		ANK repeat	339..369	CDD:293786
		Ank_2	344..>411	CDD:289560
		TyrKc	463..719	CDD:197581	77/263 (29%)
		PKc_TNNI3K	469..722	CDD:270966	76/260 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810