DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Mlkl

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001297542.1	Gene:	Mlkl / 74568	MGIID:	1921818	Length:	472	Species:	Mus musculus

Alignment Length:	309	Identity:	72/309 - (23%)
Similarity:	131/309 - (42%)	Gaps:	72/309 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PVEGVPYEEIQTKEL-----------IGTGFYGSVYRAVWRNREIALKRIRE-GCEDKKIER--- 53
            |.:.:| :::|.||:           :.|....::||..:....:.:|.... ..|...|.|
Mouse   173 PTQEIP-QDLQIKEIPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTF 236

  Fly    54 --EIYQLTKASHVNIVELYGTSRHEGCA---------LLLMEFVDGGSLSSFLHAKSKPSYSHAH 107
              ||..:.|....||:.::|.     |.         .::||:.:.|:|...|..:...:.|...
Mouse   237 NDEIKTMKKFDSPNILRIFGI-----CIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRS 296

  Fly   108 AFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFGTVVDLSQ---SISCNAG 169
            ..  ..:.|:|:..||..:   .:||:|.. ::.|...|.::|:..|    :||:   |||..|.
Mouse   297 LL--VLRAARGLYRLHHSE---TLHRNISS-SSFLVAGGYQVKLAGF----ELSKTQNSISRTAK 351

  Fly   170 TCR--------YKAPEVLQGNKP----DEKCDVYSWAITFWEILSRKEPFEQYNT--LFELYMAI 220
            :.:        |.:||.|:  .|    |.|.::||:.|..|||.:.|.|||..::  :.|| :|.
Mouse   352 STKAERSSSTIYVSPERLK--NPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIREL-VAE 413

  Fly   221 NEGERPDLSCIMSGCPADIVALLYASWDPDISKRFSMELISQSMGRILS 269
            ::.:.|    :...||..:..::......:.|:|.|::      ||.||
Mouse   414 DKKQEP----VGQDCPELLREIINECRAHEPSQRPSVD------GRSLS 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	66/286 (23%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	65/280 (23%)
Mlkl	NP_001297542.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000250\|UniProtKB:Q8NB16	1..143
Mlkl	NP_001297542.1	PHA02988	198..446	CDD:165291	62/269 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900