DRSC/TRiP Functional Genomics Resources

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Protein Alignment Takl2 and Ripk4

DIOPT Version :9

Sequence 1:NP_651090.2 Gene:Takl2 / 42692 FlyBaseID:FBgn0039015 Length:281 Species:Drosophila melanogaster
Sequence 2:NP_076152.2 Gene:Ripk4 / 72388 MGIID:1919638 Length:786 Species:Mus musculus


Alignment Length:281 Identity:79/281 - (28%)
Similarity:128/281 - (45%) Gaps:57/281 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 ELIGTGFYGSVYRA------VWRNREIALKRIREGC---------EDKKIEREIYQLTKASHVNI 66
            |.:|:|.:|.||:.      .|    :|:|     |         |..::..|..::..|....|
Mouse    26 EKVGSGGFGQVYKVRHVHWKTW----LAIK-----CSPSLHVDDRERMELLEEAKKMEMAKFRYI 81

  Fly    67 VELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNW------AHQIAQGIAYLHGM 125
            :.:||..:..  ..|:||:::.|||...|.::..|         |      .|:.|.|:.:||.|
Mouse    82 LPVYGICQEP--VGLVMEYMETGSLEKLLASEPLP---------WDLRFRIVHETAVGMNFLHCM 135

  Fly   126 QPKAVIHRDIKPLNTLLCEKGLKLKICDFGTV----VDLSQSISCNA--GTCRYKAPEVLQGNKP 184
            .| .::|.|:||.|.|| :....:||.|||..    :..|..:|.:.  ||..|..||.::....
Mouse   136 SP-PLLHLDLKPANILL-DAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSR 198

  Fly   185 --DEKCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCP---ADIVALLY 244
              |.|.||||:||..|.:|::|:||.....:..:.|.:.:|.||:|..|....|   |.::.|:.
Mouse   199 LFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQ 263

  Fly   245 ASW--DPDISKRFSMELISQS 263
            ..|  ||.:...| .|:.|::
Mouse   264 RCWHADPQVRPTF-QEITSET 283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Takl2NP_651090.2 S_TKc 14..258 CDD:214567 77/274 (28%)
PKc_like 19..268 CDD:304357 78/279 (28%)
Ripk4NP_076152.2 STKc_RIP4_like 25..290 CDD:270927 79/281 (28%)
TyrKc 26..279 CDD:197581 77/275 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..328
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..378
ANK 1 439..468
ANK repeat 442..470 CDD:293786
Ank_2 444..536 CDD:289560
ANK 471..591 CDD:238125
ANK 2 472..501
ANK repeat 473..503 CDD:293786
ANK repeat 505..536 CDD:293786
ANK 3 505..534
Ank_2 510..602 CDD:289560
ANK repeat 538..569 CDD:293786
ANK 4 538..567
ANK repeat 571..602 CDD:293786
ANK 5 571..601
ANK 600..725 CDD:238125
ANK repeat 605..636 CDD:293786
ANK 6 605..634
Ank_2 610..701 CDD:289560
ANK repeat 638..669 CDD:293786
ANK 7 638..667
ANK repeat 671..701 CDD:293786
ANK 8 671..700
Ank_2 676..766 CDD:289560
ANK 9 704..734
ANK 731..>766 CDD:238125
ANK repeat 736..766 CDD:293786
ANK 10 736..765
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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