DRSC/TRiP Functional Genomics Resources

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Protein Alignment Takl2 and Lrrk2

DIOPT Version :9

Sequence 1:NP_651090.2 Gene:Takl2 / 42692 FlyBaseID:FBgn0039015 Length:281 Species:Drosophila melanogaster
Sequence 2:NP_080006.3 Gene:Lrrk2 / 66725 MGIID:1913975 Length:2527 Species:Mus musculus


Alignment Length:235 Identity:69/235 - (29%)
Similarity:111/235 - (47%) Gaps:31/235 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EEIQTKE----LIGTGFYGSVYRAVWRNREIALKRIREGCEDKKIEREIYQLTKASHVNIVELYG 71
            :|::.:|    |:|.|.:||||||.:...|:|:|...:....:.:.:|:..|....|.:::.|..
Mouse  1873 DELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLA 1937

  Fly    72 TSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIK 136
            .....  .:|:||....|||...|. :.|.|.:.......|..:|.|:.|||...   :|:||:|
Mouse  1938 AGIRP--RMLVMELASKGSLDRLLQ-QDKASLTRTLQHRIALHVADGLRYLHSAM---IIYRDLK 1996

  Fly   137 PLNTLLC----EKGLKLKICDFGTVVDLSQ-----SISCNAGTCRYKAPEVLQGNK-PDEKCDVY 191
            |.|.||.    ...:..||.|:|    ::|     .|..:.||..::||||.:||. .:::.|||
Mouse  1997 PHNVLLFTLYPNAAIIAKIADYG----IAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVY 2057

  Fly   192 SWAI---TFWEILSR-KEPFEQYNTLFELYMAINEGERPD 227
            |:.:   ..|...|| .|.....|...||.:   :|:.||
Mouse  2058 SFGLLLHDIWTTGSRIMEGLRFPNEFDELAI---QGKLPD 2094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Takl2NP_651090.2 S_TKc 14..258 CDD:214567 68/232 (29%)
PKc_like 19..268 CDD:304357 66/223 (30%)
Lrrk2NP_080006.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 957..979
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1059 CDD:275380
LRR 4 1059..1080
leucine-rich repeat 1060..1084 CDD:275380
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1151
leucine-rich repeat 1131..1170 CDD:275380
leucine-rich repeat 1171..1197 CDD:275380
LRR 8 1174..1195
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1242
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
LRR 12 1269..1291
leucine-rich repeat 1270..1291 CDD:275380
Gem1 1333..1551 CDD:224025
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:292713
STKc_LRRK2 1884..2135 CDD:270970 67/224 (30%)
S_TKc 1884..2128 CDD:214567 67/224 (30%)
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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