DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and RIPK4

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_065690.2	Gene:	RIPK4 / 54101	HGNCID:	496	Length:	784	Species:	Homo sapiens

Alignment Length:	281	Identity:	77/281 - (27%)
Similarity:	128/281 - (45%)	Gaps:	57/281 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELIGTGFYGSVYRA------VWRNREIALKRIREGC---------EDKKIEREIYQLTKASHVNI 66
            |.:|:|.:|.||:.      .|    :|:|     |         |..::..|..::..|....|
Human    26 EKVGSGGFGQVYKVRHVHWKTW----LAIK-----CSPSLHVDDRERMELLEEAKKMEMAKFRYI 81

  Fly    67 VELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNW------AHQIAQGIAYLHGM 125
            :.:||..|..  ..|:||:::.|||...|.::..|         |      .|:.|.|:.:||.|
Human    82 LPVYGICREP--VGLVMEYMETGSLEKLLASEPLP---------WDLRFRIIHETAVGMNFLHCM 135

  Fly   126 QPKAVIHRDIKPLNTLLCEKGLKLKICDFGTV----VDLSQSISCNA--GTCRYKAPEVLQGNKP 184
            .| .::|.|:||.|.|| :....:||.|||..    :..|..:|.:.  ||..|..||.::....
Human   136 AP-PLLHLDLKPANILL-DAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSR 198

  Fly   185 --DEKCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCP---ADIVALLY 244
              |.|.||||:||..|.:|::|:||.....:..:.:.:.:|.||:|..:....|   :.::.|:.
Human   199 LFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQ 263

  Fly   245 ASW--DPDISKRFSMELISQS 263
            ..|  ||.:...| .|:.|::
Human   264 RCWQGDPRVRPTF-QEITSET 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	75/274 (27%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	76/279 (27%)
RIPK4	NP_065690.2	STKc_RIP4_like	25..290	CDD:270927	77/281 (27%)
		STYKc	26..279	CDD:214568	75/275 (27%)
		ANK	413..524	CDD:238125
		ANK repeat	437..468	CDD:293786
		Ank_2	442..534	CDD:289560
		ANK repeat	470..501	CDD:293786
		ANK	471..589	CDD:238125
		ANK repeat	503..534	CDD:293786
		Ank_2	508..600	CDD:289560
		ANK repeat	536..567	CDD:293786
		ANK repeat	569..600	CDD:293786
		ANK	598..723	CDD:238125
		ANK repeat	603..634	CDD:293786
		Ank_2	608..699	CDD:289560
		ANK repeat	636..667	CDD:293786
		ANK repeat	669..699	CDD:293786
		Ank_2	674..764	CDD:289560
		ANK	729..>764	CDD:238125
		ANK repeat	734..764	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900