DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and MAP3K20

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens

Alignment Length:	278	Identity:	92/278 - (33%)
Similarity:	142/278 - (51%)	Gaps:	28/278 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPYEEIQTKELIGTGFYGSVYRAVW--RNREIALKRIREGCEDKKIEREIYQLTKASHVNIVELY 70
            :.::::|..|..|.|.:||||||.|  :::|:|:|::      .|||:|...|:..||.||::.|
Human    11 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL------LKIEKEAEILSVLSHRNIIQFY 69

  Fly    71 GTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDI 135
            |.........::.|:...|||..::::.........|...||..:|:|:.|||...|..|||||:
Human    70 GVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDL 134

  Fly   136 KPLNTLLCEKGLKLKICDFG--------TVVDLSQSISCNAGTCRYKAPEVLQGNKPDEKCDVYS 192
            |..|.::...|: |||||||        |.:.|       .||..:.||||:|.....|.||.||
Human   135 KSRNVVIAADGV-LKICDFGASRFHNHTTHMSL-------VGTFPWMAPEVIQSLPVSETCDTYS 191

  Fly   193 WAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCPADIVALLYASWDPDISKRFSM 257
            :.:..||:|:|:.||:....|...::.:.:.||   ..|.|.||.....||:..|:.|..||.|.
Human   192 YGVVLWEMLTREVPFKGLEGLQVAWLVVEKNER---LTIPSSCPRSFAELLHQCWEADAKKRPSF 253

  Fly   258 ELISQSMGRILSEAGSIP 275
            :.|. |:...:|...|:|
Human   254 KQII-SILESMSNDTSLP 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	87/253 (34%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	87/258 (34%)
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	87/258 (34%)
		STYKc	23..260	CDD:214568	87/254 (34%)
		Leucine-zipper	287..308
		SAM_MLTK	338..408	CDD:188928
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810