DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Takl2 and MAP3K11

DIOPT Version :9

Sequence 1:NP_651090.2 Gene:Takl2 / 42692 FlyBaseID:FBgn0039015 Length:281 Species:Drosophila melanogaster
Sequence 2:NP_002410.1 Gene:MAP3K11 / 4296 HGNCID:6850 Length:847 Species:Homo sapiens


Alignment Length:297 Identity:90/297 - (30%)
Similarity:143/297 - (48%) Gaps:29/297 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PVEGVPYEEIQTKELIGTGFYGSVYRAVWRNREIALKRIREGCED------KKIEREIYQLTKAS 62
            |.|...::|::.:|:||.|.:|.|||..||...:|:|..|:..::      :.:.:|.......:
Human   108 PCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLA 172

  Fly    63 HVNIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQP 127
            |.||:.|......|....|:||:..||.||..|..:..|.:.   ..|||.|||:|:.|||....
Human   173 HPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHV---LVNWAVQIARGMHYLHCEAL 234

  Fly   128 KAVIHRDIKPLNTLLCE-------KGLKLKICDFGTVVDLSQSISCN-AGTCRYKAPEVLQGNKP 184
            ..|||||:|..|.||.:       :...|||.|||...:..::...: |||..:.||||::.:..
Human   235 VPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTF 299

  Fly   185 DEKCDVYSWAITFWEILSRKEPFEQYNTLFELY-MAINEGERPDLSCIMSGCPADIVALLYASWD 248
            .:..||:|:.:..||:|:.:.|:...:.|...| :|:|:...|    |.|.||.....|:...|.
Human   300 SKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLP----IPSTCPEPFAQLMADCWA 360

  Fly   249 PDISKRFSMELISQSM----GRILSEAGSIPPLDFYS 281
            .|..:|.....|.|.:    .::|.|   :|...|:|
Human   361 QDPHRRPDFASILQQLEALEAQVLRE---MPRDSFHS 394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Takl2NP_651090.2 S_TKc 14..258 CDD:214567 80/258 (31%)
PKc_like 19..268 CDD:304357 81/267 (30%)
MAP3K11NP_002410.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11..38
SH3_MLK1-3 45..102 CDD:212992
STKc_MLK3 113..379 CDD:271049 83/272 (31%)
STYKc 117..376 CDD:214568 82/265 (31%)
Leucine-zipper 1 403..424
Leucine-zipper 2 438..459
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..643
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..847
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.