DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and MAP3K10

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens

Alignment Length:	301	Identity:	95/301 - (31%)
Similarity:	147/301 - (48%)	Gaps:	54/301 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAPVEGVPYEEIQTKELIGTGFYGSVYRAVWRNREIALKRIR------------EGCEDKKIER 53
            :..|.| :|:.|:|.:|:||.|.:|.||||:||..|:|:|..|            :.|::.::
Human    87 LQLPQE-IPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARL-- 148

  Fly    54 EIYQLTKASHVNIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQG 118
                .....|.||:.|.|...:.....|:||:..||:||..|..:..|.:.   ..|||.|:|:|
Human   149 ----FGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHV---LVNWAVQVARG 206

  Fly   119 IAYLHGMQPKAVIHRDIKPLNTLLCE-------KGLKLKICDFGTVVDLSQSISCN-AGTCRYKA 175
            :.|||...|..:||||:|.:|.|:.|       ....|||.|||...:..::...: |||..:.|
Human   207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMA 271

  Fly   176 PEVLQGNKPDEKCDVYSWAITFWEILSRKEPFEQYNTLFELY-MAINEGERPDLSCIMSGCPADI 239
            |||::.:...:..||:|:.:..||:|:.:.|:.:.:.|...| :|:|:...|    |.|.||...
Human   272 PEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLP----IPSTCPEPF 332

  Fly   240 VALLYAS--------WDPD---------ISKRFSMELISQS 263
            ..||...        ||||         |.||  :|:|.||
Human   333 ARLLEGEPGPRDEECWDPDPHGRPDFGSILKR--LEVIEQS 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	87/281 (31%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	89/283 (31%)
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992
		TyrKc	98..365	CDD:197581	87/281 (31%)
		PKc_like	103..368	CDD:304357	86/279 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810