DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Takl2 and MAP3K9

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	XP_011535090.1	Gene:	MAP3K9 / 4293	HGNCID:	6861	Length:	1166	Species:	Homo sapiens

Alignment Length:	290	Identity:	92/290 - (31%)
Similarity:	140/290 - (48%)	Gaps:	33/290 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPYEEIQTKELIGTGFYGSVYRAVWRNREIALKRIR--------EGCEDKKIEREIYQLTKASHV 64
            :.:.|:..:|:||.|.:|.||||.|...|:|:|..|        :..|:.:.|.:::.:.|  |.
Human   139 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLK--HP 201

  Fly    65 NIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKA 129
            ||:.|.|....|....|:|||..||.|:..|..|..|.   ....|||.|||:|:.|||......
Human   202 NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPP---DILVNWAVQIARGMNYLHDEAIVP 263

  Fly   130 VIHRDIKPLNTLLCEK-------GLKLKICDFGTVVDLSQSISCN-AGTCRYKAPEVLQGNKPDE 186
            :||||:|..|.|:.:|       ...|||.|||...:..::...: |||..:.||||::.:...:
Human   264 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSK 328

  Fly   187 KCDVYSWAITFWEILSRKEPFEQYNTLFELY-MAINEGERPDLSCIMSGCPADIVALLYASWDPD 250
            ..||:|:.:..||:|:.:.||...:.|...| :|:|:...|    |.|.||.....|:...|:||
Human   329 GSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP----IPSTCPEPFAKLMEDCWNPD 389

  Fly   251 ISKRFSMELISQSMGRILSEAGSIPPLDFY 280
            ...|       .|...||.:..:|....|:
Human   390 PHSR-------PSFTNILDQLTTIEESGFF 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	86/260 (33%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	86/265 (32%)
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992
		STKc_MLK1	137..406	CDD:271047	90/282 (32%)
		TyrKc	144..403	CDD:197581	89/274 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810