DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Ripk2

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001178794.1	Gene:	Ripk2 / 362491	RGDID:	1309167	Length:	539	Species:	Rattus norvegicus

Alignment Length:	281	Identity:	88/281 - (31%)
Similarity:	136/281 - (48%)	Gaps:	33/281 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPYEEIQTKELIGTGFYGSV---YRAVWRNREIALKRIR-----EGCEDKKIEREIYQLTKASHV 64
            :||.::.....:..|..|:|   ..|.||.| :|:|.:.     ...|...|.||...|.||...
  Rat    13 IPYHKLADLHYLSRGASGTVSSARHADWRVR-VAVKHLHIHTPLLDSERNDILREAEILHKARFS 76

  Fly    65 NIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSK-PSYSHAHAFNWAHQIAQGIAYLHGMQPK 128
            .|:.:.|.........::.|::..|||:..||.|:: |..:....|...|:||.|:.|||.|.|
  Rat    77 YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPEIAWPLRFRILHEIALGVNYLHNMNP- 140

  Fly   129 AVIHRDIKPLNTLLCEKGLKLKICDFG----TVVDLSQSISCNA----GTCRYKAPEVL---QGN 182
            .::|.|:|..|.|| :....:||.|||    .::.||||.|..:    ||..|..||..   |.:
  Rat   141 PLLHHDLKTQNILL-DNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKS 204

  Fly   183 KPDEKCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCPADI------VA 241
            :...|.|:||:|:..||:||||:|||:.....::..::::|.||:.|  ....|.||      ::
  Rat   205 RASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPNTS--EENLPFDIPHRGLMIS 267

  Fly   242 LLYASW--DPDISKRFSMELI 260
            |:.:.|  :||....|...||
  Rat   268 LIQSGWAQNPDERPSFLKCLI 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	84/271 (31%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	86/270 (32%)
Ripk2	NP_001178794.1	STKc_RIP2	20..303	CDD:270928	86/274 (31%)
		STYKc	21..290	CDD:214568	86/273 (32%)
		CARD_RIP2_CARD3	437..523	CDD:176764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900