DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and LIMK1

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_511139.2	Gene:	LIMK1 / 32207	FlyBaseID:	FBgn0283712	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	80/313 - (25%)
Similarity:	128/313 - (40%)	Gaps:	70/313 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELIGTGFYGSVYRAVWR--NREIALKRIREGCED--KKIEREIYQLTKASHVNIVELYGTSRHEG 77
            |.:|.||:|.|::...|  ...:.||.:....|:  :...:|:..|....|.::::..|....:.
  Fly   405 EKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYKDK 469

  Fly    78 CALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNW------AHQIAQGIAYLHGMQPKAVIHRDIK 136
            ...::.|:|.||.|...:|       ..|....|      |..||.|::|||.|.   :||||:.
  Fly   470 KLHMVTEYVAGGCLKELIH-------DPAQVLPWPQRVRLARDIACGMSYLHSMN---IIHRDLN 524

  Fly   137 PLNTLLCEKGLKLKICDFGTV--VDLSQSISCN------------------AGTCR--------- 172
            .:|.|:.| ...:.:.|||..  ||..:..|.|                  :||.|
  Fly   525 SMNCLVRE-DRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQ 588

  Fly   173 ---------YKAPEVLQGNKPDEKCDVYSWAITFWEILSRKE---PFEQYNTLFELYMAINEGER 225
                     :.|||:::|.|.|||.||:|:.|...||:.|.|   .|...|:.|.|    |:.|.
  Fly   589 RYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSL----NQQEF 649

  Fly   226 PDLSCIMSGCPADIVALLYASWDPDISKRFSMELISQSMGRILSE--AGSIPP 276
            .:..|  :.||...|.:.:...|.:...|...|.:...:.|:..:  |..:||
  Fly   650 REKFC--AQCPEPFVKVAFVCCDLNPDMRPCFETLHVWLQRLADDLAADRVPP 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	75/291 (26%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	76/299 (25%)
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	76/302 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930