DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Lrrk1

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001178553.1	Gene:	Lrrk1 / 308703	RGDID:	1308000	Length:	2013	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	81/291 - (27%)
Similarity:	128/291 - (43%)	Gaps:	64/291 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LIGTGFYGSV-YRAVWRNREIALKRIREGCEDKKIE---------------------------RE 54
            ::|.|..|:| |:|.::.:.:|:||.    ..||.:                           :|
  Rat  1247 ILGQGGSGTVIYQAQYQGQPVAVKRF----HIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQE 1307

  Fly    55 IYQLTKASHVNIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSKPS----YSHAHAFNWAHQI 115
            ...|....|..||.|.|.|.|..|  ..:|....|||::.|...:|.|    ..|......|:||
  Rat  1308 ASMLHALQHPCIVSLIGISIHPLC--FALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQI 1370

  Fly   116 AQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLK----LKICDFGTVVDLSQSISCNA----GTCR 172
            |.|:||||   .|.:|..|:|..|.|:....:|    :|:.|:|.   ..||....|    ||..
  Rat  1371 ASGLAYLH---KKNIIFCDLKSDNILVWSLSVKELINIKLSDYGI---SRQSFHEGALGVEGTPG 1429

  Fly   173 YKAPEVLQGNKPDEKCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCPA 237
            |:|||:......|||.|::|:.:..:|:||.:.|...::.| ::...:::|.||.|     |.|.
  Rat  1430 YQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQL-QIVKKLSKGIRPVL-----GQPE 1488

  Fly   238 DI-----VALLYASWDPDISKR-FSMELISQ 262
            ::     .||:...||....|| .::.::||
  Rat  1489 EVQFYRLQALMMECWDTKPEKRPLALSVVSQ 1519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	79/285 (28%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	81/290 (28%)
Lrrk1	NP_001178553.1	ANK	91..214	CDD:238125
		ANK repeat	91..119	CDD:293786
		Ank_2	126..221	CDD:289560
		ANK repeat	156..186	CDD:293786
		ANK repeat	188..218	CDD:293786
		LRR_RI	<273..464	CDD:238064
		LRR	<279..513	CDD:227223
		leucine-rich repeat	281..303	CDD:275380
		leucine-rich repeat	304..330	CDD:275380
		leucine-rich repeat	331..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..451	CDD:275380
		leucine-rich repeat	452..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		leucine-rich repeat	499..549	CDD:275380
		leucine-rich repeat	550..572	CDD:275380
		Gem1	635..>781	CDD:224025
		P-loop_NTPase	639..821	CDD:304359
		COR	844..1036	CDD:292713
		S_TKc	1247..1511	CDD:214567	78/281 (28%)
		STKc_LRRK1	1248..1523	CDD:270969	81/290 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900