DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Map3k10

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001382027.1	Gene:	Map3k10 / 308463	RGDID:	1308381	Length:	940	Species:	Rattus norvegicus

Alignment Length:	287	Identity:	95/287 - (33%)
Similarity:	146/287 - (50%)	Gaps:	34/287 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAPVEGVPYEEIQTKELIGTGFYGSVYRAVWRNREIALKRIREGCE------DKKIEREIYQLT 59
            :..|.| :|:.|:|.:|:||.|.:|.||||:||..|:|:|..|...|      .:::.:|.....
  Rat    87 LQLPQE-IPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFG 150

  Fly    60 KASHVNIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHG 124
            ...|.||:.|.|.........|:||:..||:||..|..:..|.:.   ..|||.|:|:|:.|||.
  Rat   151 ALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHV---LVNWAVQVARGMNYLHN 212

  Fly   125 MQPKAVIHRDIKPLNTLLCE-------KGLKLKICDFGTVVDLSQSISCN-AGTCRYKAPEVLQG 181
            ..|..:||||:|.:|.|:.|       ....|||.|||...:..::...: |||..:.||||::.
  Rat   213 DAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRL 277

  Fly   182 NKPDEKCDVYSWAITFWEILSRKEPFEQYNTLFELY-MAINEGERPDLSCIMSGCPADIVALLYA 245
            :...:..||:|:.:..||:|:.:.|:.:.:.|...| :|:|:...|    |.|.||.....||..
  Rat   278 SLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLP----IPSTCPEPFARLLEE 338

  Fly   246 SWDPD---------ISKRFSMELISQS 263
            .||||         |.|:  :|:|.||
  Rat   339 CWDPDPHGRPDFGSILKQ--LEVIEQS 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	87/267 (33%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	89/269 (33%)
Map3k10	NP_001382027.1	Leucine-zipper 1	384..405
		Leucine-zipper 2	419..440
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..599
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..658
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..916
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810