DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Ripk1

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001100820.1	Gene:	Ripk1 / 306886	RGDID:	1310158	Length:	658	Species:	Rattus norvegicus

Alignment Length:	282	Identity:	85/282 - (30%)
Similarity:	131/282 - (46%)	Gaps:	39/282 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IQTKELIGTGFYGSVYRAVWRNRE-IALKRIREGCE----DKKIEREIYQLTKASHVNIVELYGT 72
            ::.|:|...|| |.|.....|... :.||::..|..    ::.:..|...:.:..|..:|:|.|.
  Rat    18 LERKDLDSGGF-GKVSLCFHRTHGFVILKKVYTGPNRAEYNEALLEEGKMMHRLRHDRVVKLLGI 81

  Fly    73 SRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKP 137
            ...||...|:||:::.|:|...|  |:|.|...:.......:|.:|:.|||   .:.|||:|:||
  Rat    82 IIEEGNYSLVMEYMEQGNLMHVL--KTKESVPLSVKGRIIVEIIEGMHYLH---DEGVIHKDLKP 141

  Fly   138 LNTLLCEKGLKLKICDFGTVV----------------DLSQSISCNAGTCRYKAPEVLQ--GNKP 184
            .| :|.::...:||.|.|...                :.|.....|.||..|.|||.|.  ..||
  Rat   142 EN-ILVDRDFHIKIADLGVASFKTWSKLTKEEHNKQREASSVTKKNGGTLYYMAPEHLTDINTKP 205

  Fly   185 DEKCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCPADIVALLYASW-- 247
            .||.||||:||..|.|.:.|||:|......:..:.||.|.||::..|:..||.:|::|:...|
  Rat   206 TEKSDVYSFAIVLWAIFANKEPYENVICTEQFLVCINSGNRPNVEDILEFCPREIISLMERCWQT 270

  Fly   248 DPD-------ISKRFSMELISQ 262
            :|:       |.|.|....:||
  Rat   271 NPEDRPTFFGIEKEFKPFYLSQ 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	83/275 (30%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	83/276 (30%)
Ripk1	NP_001100820.1	PKc_like	23..290	CDD:419665	82/273 (30%)
Ripk1	NP_001100820.1	Death_RIP1	570..655	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900