DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Lrrk2

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_001178718.1	Gene:	Lrrk2 / 300160	RGDID:	1561168	Length:	2526	Species:	Rattus norvegicus

Alignment Length:	327	Identity:	83/327 - (25%)
Similarity:	137/327 - (41%)	Gaps:	75/327 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EEIQTKE----LIGTGFYGSVYRAVWRNREIALKRIREGCEDKKIEREIYQLTKASHVNIVELYG 71
            :|::.:|    |:|.|.:||||||.:...|:|:|...:....:.:.:|:..|....|.:::.|..
  Rat  1872 DELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLA 1936

  Fly    72 TSRHEGCALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIK 136
            .....  .:|:||....|||...|. :.|.|.:.......|..:|.|:.|||...   :|:||:|
  Rat  1937 AGIRP--RMLVMELASKGSLDRLLQ-QDKASLTRTLQHRIALHVADGLRYLHSAM---IIYRDLK 1995

  Fly   137 PLNTLLC----EKGLKLKICDFGTVVDLSQ-----SISCNAGTCRYKAPEVLQGNK-PDEKCDVY 191
            |.|.||.    ...:..||.|:|    ::|     .|..:.||..::||||.:||. .:::.|||
  Rat  1996 PHNVLLFTLYPNAAIIAKIADYG----IAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVY 2056

  Fly   192 SWAITFWEILSR-----------------------KEPFEQY--------NTLFELYMAINEGER 225
            |:.:...:|.:.                       .:|.::|        ..|....:..|..||
  Rat  2057 SFGLLLHDIWTTGNRIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITKCLKENPQER 2121

  Fly   226 P------------DLSCIMSG--CPADIVALLYASWDPDISKRFSMELISQSMGRILSEAGSIPP 276
            |            :|.|:|..  .|.||.....|:.:.: |||.::.|     |...:|.|.:..
  Rat  2122 PTSAQVFDILNSAELICLMRHIFIPKDITVECIAATNLN-SKRATLWL-----GCGNTEKGQLSL 2180

  Fly   277 LD 278
            ||
  Rat  2181 LD 2182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	76/302 (25%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	76/303 (25%)
Lrrk2	NP_001178718.1	leucine-rich repeat	984..1011	CDD:275380
		leucine-rich repeat	1012..1035	CDD:275380
		leucine-rich repeat	1036..1058	CDD:275380
		leucine-rich repeat	1059..1083	CDD:275380
		leucine-rich repeat	1084..1107	CDD:275380
		leucine-rich repeat	1108..1129	CDD:275380
		leucine-rich repeat	1130..1173	CDD:275380
		leucine-rich repeat	1174..1196	CDD:275380
		leucine-rich repeat	1197..1220	CDD:275380
		leucine-rich repeat	1221..1245	CDD:275380
		Gem1	1332..1550	CDD:224025
		RocCOR	1333..1506	CDD:206741
		COR	1526..1739	CDD:292713
		S_TKc	1883..2145	CDD:214567	68/271 (25%)
		STKc_LRRK2	1883..2134	CDD:270970	65/260 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900