DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Map3k21

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_663583.2	Gene:	Map3k21 / 234878	MGIID:	2385307	Length:	1002	Species:	Mus musculus

Alignment Length:	306	Identity:	99/306 - (32%)
Similarity:	150/306 - (49%)	Gaps:	33/306 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 APVEGVPYEEIQTKELIGTGFYGSVYRAVWRNREIALKRIREGCED------KKIEREIYQLTKA 61
            :||. |.:|.::.|||||.|.:|.||||.|:.:|:|:|..|...|.      :.:.||.......
Mouse   101 SPVH-VDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAML 164

  Fly    62 SHVNIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSK----PSYSHAHAF------NWAHQIA 116
            .|.||::|.|....:....|::||..||:|:..|.|.:.    |....|...      |||.|||
Mouse   165 RHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPPQVLVNWAVQIA 229

  Fly   117 QGIAYLHGMQPKAVIHRDIKPLNTLLCEK-------GLKLKICDFGTVVDLSQSISCN-AGTCRY 173
            :|:.|||......::|||:|..|.||.||       ...|||.|||...:..::...: |||..:
Mouse   230 RGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMSAAGTYAW 294

  Fly   174 KAPEVLQGNKPDEKCDVYSWAITFWEILSRKEPFEQYNTLFELY-MAINEGERPDLSCIMSGCPA 237
            .||||::.:...:..|::|:.:..||:|:.:.|:...:.|...| :|:|:...|    |.|.||.
Mouse   295 MAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP----IPSTCPE 355

  Fly   238 DIVALLYASWDPDISKRFSMELISQSMGRILSEA--GSIPPLDFYS 281
            ....|:...|:.|...|.|..||.|.:..| .||  .::|...|:|
Mouse   356 PFAKLMKECWEQDPHIRPSFALILQQLTAI-EEAVLTNMPQESFHS 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	86/268 (32%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	86/273 (32%)
Map3k21	NP_663583.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		SH3	28..82	CDD:302595
		TyrKc	110..382	CDD:197581	89/275 (32%)
		PKc_like	115..385	CDD:304357	87/273 (32%)
		Leucine-zipper 1	409..430
		Leucine-zipper 2	444..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..778
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	797..823
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	878..899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810