DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Takl2 and Ripk2

DIOPT Version :9

Sequence 1:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster
Sequence 2:	NP_620402.1	Gene:	Ripk2 / 192656	MGIID:	1891456	Length:	539	Species:	Mus musculus

Alignment Length:	281	Identity:	89/281 - (31%)
Similarity:	136/281 - (48%)	Gaps:	33/281 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VPYEEIQTKELIGTGFYGSV---YRAVWRNREIALKRIR-----EGCEDKKIEREIYQLTKASHV 64
            :||.::.....:..|..|:|   ..|.||.| :|:|.:.     ...|...|.||...|.||...
Mouse    13 IPYHKLADLHYLSRGASGTVSSARHADWRVR-VAVKHLHIHTPLLDSERNDILREAEILHKARFS 76

  Fly    65 NIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSK-PSYSHAHAFNWAHQIAQGIAYLHGMQPK 128
            .|:.:.|.........::.|::..|||:..||.|:: |..:....|...|:||.|:.|||.|.|
Mouse    77 YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGVNYLHNMNP- 140

  Fly   129 AVIHRDIKPLNTLLCEKGLKLKICDFG----TVVDLSQSISCNA----GTCRYKAPEVL---QGN 182
            .::|.|:|..|.|| :....:||.|||    .::.||||.|..:    ||..|..||..   |.:
Mouse   141 PLLHHDLKTQNILL-DNEFHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKS 204

  Fly   183 KPDEKCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGERPDLSCIMSGCPADI------VA 241
            :...|.|:||:|:..||:||||:|||:.....::..::::|.|||.|  ....|.||      ::
Mouse   205 RASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTS--EENLPFDIPHRGLMIS 267

  Fly   242 LLYASW--DPDISKRFSMELI 260
            |:.:.|  :||....|...||
Mouse   268 LIQSGWAQNPDERPSFLKCLI 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	85/271 (31%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	87/270 (32%)
Ripk2	NP_620402.1	STKc_RIP2	20..303	CDD:270928	87/274 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..368
		CARD_RIP2_CARD3	437..522	CDD:176764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4885
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950