DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45049 and LIM2

DIOPT Version :9

Sequence 1:	NP_001287471.1	Gene:	CG45049 / 42691	FlyBaseID:	FBgn0266409	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_085915.2	Gene:	LIM2 / 3982	HGNCID:	6610	Length:	215	Species:	Homo sapiens

Alignment Length:	207	Identity:	52/207 - (25%)
Similarity:	82/207 - (39%)	Gaps:	64/207 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 CGVIVVALMIMALASTDW----LMASDWRQGLFVHC------IEDDSV--PPLPFNIQDPPGCYW 145
            |..:...|:::|:|:..|    |..|...|||:.:|      ::.||:  ||     ...||..|
Human    11 CAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIGEPP-----GQGPGRAW 70

  Fly   146 TR---DVG-----------------------YIKATAALCIITLITDVIATVLTGLGLRTQNHNL 184
            .:   |:|                       |..||.|..|::.:..:...:   :|:....|
Human    71 GKSRADLGAQGHLYSRWRTLRLKEGKGATQAYWNATRAFMILSALCAISGII---MGIMAFAH-- 130

  Fly   185 KYKFYRI-----AVLVMLVSLLAVLSALIVY---PVCFAGELTMANRRV--WEFGWAYGVGWGAA 239
            :..|.||     |.::...|.|.|:.||.:|   .|.|.|      ||.  |.|.|:|.:||.|.
Human   131 QPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLG------RRFGDWRFSWSYILGWVAV 189

  Fly   240 IFLFGAVVLLLC 251
            :..|.|.:..:|
Human   190 LMTFFAGIFYMC 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45049	NP_001287471.1	PMP22_Claudin	<150..249	CDD:304458	32/131 (24%)
LIM2	NP_085915.2	PMP22_Claudin	1..199	CDD:328820	51/203 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910