DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4813 and rnf220a

DIOPT Version :9

Sequence 1:	NP_651088.1	Gene:	CG4813 / 42690	FlyBaseID:	FBgn0039013	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	XP_021336297.1	Gene:	rnf220a / 561654	ZFINID:	ZDB-GENE-060929-1006	Length:	695	Species:	Danio rerio

Alignment Length:	483	Identity:	150/483 - (31%)
Similarity:	210/483 - (43%)	Gaps:	126/483 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ICPTCDVKIKRSQVADHCQVEMERL----------HNPISAVTPPTPTS------------GATA 67
            |||.|.|.::..::.:|.:.|||||          |..|: |.|.||.|            ....
Zfish   230 ICPICQVLLRPGELQEHMEQEMERLTHMHISKNPSHKDIN-VAPGTPKSLLLSVHIKREGESPVV 293

  Fly    68 SEESGSVSGGRQPWSVFQRVQRNRQARQRQ------RTRKRPASPAPPATVNPTVAAAPPPAAAT 126
            |..|...:.....:..|.||:.|||.|...      |...:.:..:||..| |......|.....
Zfish   294 SPLSSDEAHHSDRYQTFLRVRANRQTRLNVDDLCWCRRYAKESFKSPPIPV-PRGVPLAPCCLRH 357

  Fly   127 PSVAAAESSQP----TCPVCNHNFPQSNIQE----HVNHCLRQSRRNGQANGERHSSEDSEDSEE 183
            ..:...:..:|    .||:|  :.|.:..:|    ||..||  .:|.| |..|..:..:.|:...
Zfish   358 ARIGKMKRRKPEDGQVCPLC--SAPLAGTEEEMSRHVEQCL--FKREG-ATEEDSADVEGENGTR 417

  Fly   184 YEEYEWAGQKRIRVSTLVQGGYSALGLGQRIKYNGSQQAQDDEDEDLNVDEDDTHIYGPTQYGEG 248
            :|||||.||||:|.:||::||:...|...     .|.:...|.|.||:||.|||..||..||.|.
Zfish   418 FEEYEWCGQKRVRATTLLEGGFRGTGFAM-----CSTKESHDSDADLDVDGDDTLEYGKAQYTEA 477

  Fly   249 DVIPLVNEDTEGNVSEADVTSYVRRLISSSDGPK----PNHSSEATEQEPASTSNVEAPPASEEP 309
            |:||...|| :|...|.:.   :|..:.:...|.    |..|..|:::.| ||||.|:.......
Zfish   478 DIIPCSGED-QGEAKEREA---LRGAVLNGGVPSNRITPEFSKWASDEMP-STSNGESSKQEPSS 537

  Fly   310 STSRSTRSTSQNQQ----------QIIESLKAKLRLYEKQ-AQG-KYKCLICI------------ 350
            |:|.||:.|.:|.:          ..:|:|||::|..||| .:| :||||||:
Zfish   538 SSSSSTQRTCKNSEIEKITEDSTATTLEALKARIRELEKQILRGDRYKCLICMRKPTQTGADGKI 602

  Fly   351 ---------------------------------------------DDYKNPAISVSCWHVHCEQC 370
                                                         |.|..|..|:.|||||||:|
Zfish   603 QAAERHGSAEALQLGVYCLYRGYVTGCSTATAGSSGIKKLLPLRRDSYTMPLTSIQCWHVHCEEC 667

  Fly   371 WLQTLGARKLCPQCNSITTPKDLRRIYL 398
            ||:|||.:|||||||:||:|.||||:||
Zfish   668 WLRTLGNKKLCPQCNTITSPGDLRRVYL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4813	NP_651088.1	RNF220	22..281	CDD:292548	86/291 (30%)
CG4813	NP_651088.1	zf-C3HC4_2	346..384	CDD:290634	25/94 (27%)
rnf220a	XP_021336297.1	RNF220	224..507	CDD:318197	86/292 (29%)
rnf220a	XP_021336297.1	RING-HC_RNF220	648..682	CDD:319477	22/33 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596151
Domainoid	1	1.000	77	1.000	Domainoid score	I8846
eggNOG	1	0.900	-	-		E1_28IQH
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	197	1.000	Inparanoid score	I3784
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1583675at2759
OrthoFinder	1	1.000	-	-		FOG0007312
OrthoInspector	1	1.000	-	-		oto41377
orthoMCL	1	0.900	-	-		OOG6_106737
Panther	1	1.100	-	-	LDO	PTHR13459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5368
SonicParanoid	1	1.000	-	-		X5422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790