Protein Alignment CG4813 and RNF220

DIOPT Version :9

• Sequence 1: NP_651088.1
• Gene: CG4813 / 42690
• FlyBaseID: FBgn0039013
• Length: 398
• Species: Drosophila melanogaster
• Sequence 2: NP_001363415.1
• Gene: RNF220 / 55182
• HGNCID: 25552
• Length: 592
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 146/408 - (35%)
• Similarity: 201/408 - (49%)
• Gaps: 72/408 - (17%)

  Fly    25 ICPTCDVKIKRSQVADHCQVEMERLHN-PIS-------AVTPPTPTS------------GATASE 69
            |||.|.|.::.|::.:|.:.|:|:|.. |.|       |:.|.||.|            ..|||.
Human   223 ICPICQVLLRPSELQEHMEQELEQLAQLPSSKNSLLKDAMAPGTPKSLLLSASIKREGESPTASP 287

  Fly    70 ESGSVSG--GRQPWSVFQRVQRNRQARQRQRTRKRPASPAPPATVNPTVAAAPPPAAATPSVAAA 132
            .|.:...  ....:..|.||:.|||.|...|..|..........|
Human   288 HSSATDDLHHSDRYQTFLRVRANRQTRLNARIGKMKRRKQDEGQV-------------------- 332

  Fly   133 ESSQPTCPVCNHNF--PQSNIQEHVNHCLRQSRRNGQANGERHSSE-DSEDSEEYEEYEWAGQKR 194
                  ||:||...  .:..:..||.|||  |:|.|....|..:.: :.|::..:|||||.||||
Human   333 ------CPLCNRPLAGSEQEMSRHVEHCL--SKREGSCMAEDDAVDIEHENNNRFEEYEWCGQKR 389

  Fly   195 IRVSTLVQGGYSALGLGQRIKYNGSQQAQDDEDEDLNVDEDDTHIYGPTQYGEGDVIPLVNEDTE 259
            ||.:||::||:...|.   |..:|.:  ..|.|.||:||.|||..||..||.|.||||...|:.
Human   390 IRATTLLEGGFRGSGF---IMCSGKE--NPDSDADLDVDGDDTLEYGKPQYTEADVIPCTGEEP- 448

  Fly   260 GNVSEADVTSYVRRLISSSDGPK----PNHSSEATEQEPASTSNVEAPPASEEPSTSRST---RS 317
               .||.....:|..:.:...|.    |..|..|:::.| ||||.|:........|.:::   :.
Human   449 ---GEAKEREALRGAVLNGGPPSTRITPEFSKWASDEMP-STSNGESSKQEAMQKTCKNSDIEKI 509

  Fly   318 TSQNQQQIIESLKAKLRLYEKQ-AQG-KYKCLICIDDYKNPAISVSCWHVHCEQCWLQTLGARKL 380
            |..:.....|:|||::|..|:| ::| :||||||:|.|..|..|:.|||||||:|||:||||:||
Human   510 TEDSAVTTFEALKARVRELERQLSRGDRYKCLICMDSYSMPLTSIQCWHVHCEECWLRTLGAKKL 574

  Fly   381 CPQCNSITTPKDLRRIYL 398
            |||||:||.|.|||||||
Human   575 CPQCNTITAPGDLRRIYL 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4813	NP_651088.1	RNF220	22..281	CDD:292548	85/280 (30%)
		zf-C3HC4_2	346..384	CDD:290634	26/37 (70%)
RNF220	NP_001363415.1	RNF220	219..468	CDD:374229	85/281 (30%)
		RING-HC_RNF220	539..579	CDD:319477	28/39 (72%)
		RING-HC finger (C3HC4-type)	540..578	CDD:319477	26/37 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159885
Domainoid	1	1.000	80	1.000	Domainoid score	I8637
eggNOG	1	0.900	-	-		E1_28IQH
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10036
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3825
Isobase	1	0.950	-	0	Normalized mean entropy	S6937
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1583675at2759
OrthoFinder	1	1.000	-	-		FOG0007312
OrthoInspector	1	1.000	-	-		oto90210
orthoMCL	1	0.900	-	-		OOG6_106737
Panther	1	1.100	-	-	LDO	PTHR13459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5368
SonicParanoid	1	1.000	-	-		X5422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740