Protein Alignment Irp-1A and LEU1

DIOPT Version :10

• Sequence 1: NP_477371.1
• Gene: Irp-1A / 42689
• FlyBaseID: FBgn0024958
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_011506.1
• Gene: LEU1 / 852875
• SGDID: S000002977
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 879
• Identity: 208/879 - (23%)
• Similarity: 338/879 - (38%)
• Gaps: 194/879 - (22%)

  Fly    69 WTPSLKQETSDVEVSFKPARVILQDFTG-------------VPAVVDFAAMRDAVRELGGNPEKI 120
            :|||....|...:|.  .|.|:.||..|             |.:...|..:.:|.|       |:
Yeast     3 YTPSKGPRTLYDKVF--DAHVVHQDENGSFLLYIDRHLVHEVTSPQAFEGLENAGR-------KV 58

  Fly   121 NPICPADLVIDHSVQVD----------FVRSSDALTKNESLEFQRNKERFTFLKWG---ARAFDN 172
            ..:......:||::..:          |::.:|:..:.::||  .|.::|....:|   ||
Yeast    59 RRVDCTLATVDHNIPTESRKNFKSLDTFIKQTDSRLQVKTLE--NNVKQFGVPYFGMSDAR---- 117

  Fly   173 MLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIE 237
                   .||||.:..|             :|. .|...:||..||||:.....|.|.:|:|..|
Yeast   118 -------QGIVHTIGPE-------------EGF-TLPGTTVVCGDSHTSTHGAFGSLAFGIGTSE 161

  Fly   238 AEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSI 302
            .|.|:..|:|.....:.:...:.|||.|..||.||:|.|...:...|..|..:||.|..:..||:
Yeast   162 VEHVLATQTIIQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSM 226

  Fly   303 ADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQY 367
            ..|.::.||..|.||..|....||.|..|.:....:.|..:    :.||....:... .|:..::
Yeast   227 EARMSMCNMAIEAGARAGMIKPDETTFQYTKGRPLAPKGAE----WEKAVAYWKTLK-TDEGAKF 286

  Fly   368 TESVTLDLSTVVTSVSGPKRPHDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDG 432
            ...:.::...|:.:::....|.|.:.::....|.|: :..|:...|.   ..|||..|.......
Yeast   287 DHEINIEAVDVIPTITWGTSPQDALPITGSVPDPKN-VTDPIKKSGM---ERALAYMGLEPNTPL 347

  Fly   433 KSYKIGHGSVVIAAITSCTNTSNPSVMLGAGLLAKNAVQKGLSILPYIKTSL-SPGSGVVTYYLR 496
            ||.|:..     ..|.||||.....:...|      ||.:|..:...||.:: .||||:|.....
Yeast   348 KSIKVDK-----VFIGSCTNGRIEDLRSAA------AVVRGQKLASNIKLAMVVPGSGLVKKQAE 401

  Fly   497 ESGVIPYLEQLGFDIVGYGCMTCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRA 561
            ..|:....::.||:....||..|:|    ::.::::..|:    |..  :.|||||||....:|
Yeast   402 AEGLDKIFQEAGFEWREAGCSICLG----MNPDILDAYER----CAS--TSNRNFEGRQGALSR- 455

  Fly   562 NYLASPLLVIAYAIAGR-VDI-DFEIEPLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQE 624
            .:|.||.:..|..|||. ||| :||.:.....|...||...|    ..|::...:.|..|...::
Yeast   456 THLMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSED----EKELESAAYDHAEPVQPED 516

  Fly   625 VYSKIQLGSRDWQTLEVSDSKLYPWSEISTYIKLPPF--FEGMTRALPKLKGIEKARCLLLLGDS 687
            ....|.........::..|:...|.|.     .:.||  .||::..|.|.              :
Yeast   517 APQDIANDELKDIPVKSDDTPAKPSSS-----GMKPFLTLEGISAPLDKA--------------N 562

  Fly   688 VTTDHISPAGSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGP 752
            |.||.|.|...:       :.:...||....|..:..|:.:........|
Yeast   563 VDTDAIIPKQFL-------KTIKRTGLKKGLFYEWRFRKDDQGKDQETDF--------------- 605

  Fly   753 STLHVPSGEEMDIFDAAERYASEGTPLVLVVGKDYGSGSSRD---WAAKGPFLLGIKAVIAESYE 814
             .|:|....|.:|              ::|.|.::|.||||:   ||.|.   .|||::||.||.
Yeast   606 -VLNVEPWREAEI--------------LVVTGDNFGCGSSREHAPWALKD---FGIKSIIAPSYG 652

  Fly   815 RIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNIVLP----EGEL---KPGQRIQVDADGNVF 872
            .|..:|....|::|           ::|..:.:.:.::|    .|:|   .|.|:| :|:||||.
Yeast   653 DIFYNNSFKNGLLP-----------IRLDQQIIIDKLIPIANKGGKLCVDLPNQKI-LDSDGNVL 705

  Fly   873 ETTLRFD-----------TEVDITYYKNGGILNY 895
            ......:           .::.||..|...|..|
Yeast   706 VDHFEIEPFRKHCLVNGLDDIGITLQKEEYISRY 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	208/879 (24%)
LEU1	NP_011506.1	PRK05478	9..480	CDD:235490	134/537 (25%)
		leuD	545..736	CDD:129275	56/256 (22%)