DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and ACO1

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_013407.1	Gene:	ACO1 / 851013	SGDID:	S000004295	Length:	778	Species:	Saccharomyces cerevisiae

Alignment Length:	843	Identity:	245/843 - (29%)
Similarity:	359/843 - (42%)	Gaps:	187/843 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPI---CPADLVIDHSVQV------D 137
            :..:|.||..||.|...|::.|.:        .|.|:...|:   |      ||.:|.      |
Yeast    85 LKLRPDRVACQDATAQMAILQFMS--------AGLPQVAKPVTVHC------DHLIQAQVGGEKD 135

  Fly   138 FVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSA 202
            ..|:.|.           |||.:.||. .|.|..||....|||||:||:.||..|
Yeast   136 LKRAIDL-----------NKEVYDFLA-SATAKYNMGFWKPGSGIIHQIVLENYA---------- 178

  Fly   203 DGSKILYPDS-VVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPL 266
                  :|.: ::||||||....|||.|..||||.:|..||.|:...:..|:::|.:|.||:...
Yeast   179 ------FPGALIIGTDSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGW 237

  Fly   267 ATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSY 331
            .:..|::|.:.......|..||.||::|.||...|.....||.||..|.|||...||.:::.:.|
Yeast   238 TSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIEY 302

  Fly   332 MRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVSVSS 396
            :..|.|. |..|..:.|.|      |....|:|.:|.|.|.:||:|:...::||..|.....||.
Yeast   303 LEATGRG-KIADFAKLYHK------DLLSADKDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSK 360

  Fly   397 MCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVMLG 461
            |.|                     :|.:..:..|           |.:..|.||||:|...:...
Yeast   361 MKE---------------------VAVANNWPLD-----------VRVGLIGSCTNSSYEDMSRS 393

  Fly   462 AGLLAKNAVQKGLSILPYIKT--SLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSG 524
            |.:: |:|...||.    .||  :::|||..:...:...|.:...::.|..::...|..|||.
Yeast   394 ASIV-KDAAAHGLK----SKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQ-- 451

  Fly   525 PLDENVVNTIEKNGLVCCGVLSGNRNFEGRI--HPNTRANYLASPLLVIAYAIAGRVDIDFEIEP 587
             .|...:...:||.:|.    |.||||..|.  :|.|.| ::|||.||.|:||||    |....|
Yeast   452 -WDRRDIKKGDKNTIVS----SYNRNFTSRNDGNPQTHA-FVASPELVTAFAIAG----DLRFNP 506

  Fly   588 LG---VDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVY----SKIQLGSRDWQTLEVSDSK 645
            |.   .|.:|.|..|:.           .|...:|   |..|    :..|....|..|:||   |
Yeast   507 LTDKLKDKDGNEFMLKP-----------PHGDGLP---QRGYDAGENTYQAPPADRSTVEV---K 554

  Fly   646 LYPWSEISTYIKLPPF--FEGM-TRALPKL-KGIEKARCLLLLGDSVTTDHISPAGSIARKSPAA 706
            :.|.|:....:|  ||  ::|. .:.:|.| |.:.|          .||||||.||.
Yeast   555 VSPTSDRLQLLK--PFKPWDGKDAKDMPILIKAVGK----------TTTDHISMAGP-------- 599

  Fly   707 RYLSERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAER 771
             :|..||......|:|             ....|...||.|:    ...:|.:||...:.|.|..
Yeast   600 -WLKYRGHLENISNNY-------------MIGAINAENKKAN----CVKNVYTGEYKGVPDTARD 646

  Fly   772 YASEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQS 836
            |..:|...|::..:::|.||||:.||..|..||..|:|.:|:.|||.:||...|::||.|  ...
Yeast   647 YRDQGIKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNF--KNP 709

  Fly   837 ADTLKLSGREVYNIVLPEGELKPGQRIQV---DADGNVFETTL--RFDTEVDITYYKNGGILN 894
            ||..|::..:..:| |...||.||:.:.:   ..:|..::..|  .|:.| .|.::|.|..||
Yeast   710 ADYDKINPDDRIDI-LGLAELAPGKPVTMRVHPKNGKPWDAVLTHTFNDE-QIEWFKYGSALN 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	245/843 (29%)
		AcnA_IRP	88..579	CDD:153136	152/504 (30%)
		AcnA_IRP_Swivel	683..852	CDD:238812	51/168 (30%)
ACO1	NP_013407.1	aconitase_mito	41..772	CDD:273561	245/843 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810