DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and ACO1

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_195308.1	Gene:	ACO1 / 829737	AraportID:	AT4G35830	Length:	898	Species:	Arabidopsis thaliana

Alignment Length:	904	Identity:	542/904 - (59%)
Similarity:	671/904 - (74%)	Gaps:	21/904 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NPFAQFQESFTQ-DGNVY-KYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILG 68
            |||....::..: ||..: .|:.||:: |.:.:.||:|||:|||||:||||.|.|..|||:.||.
plant     5 NPFRSILKALEKPDGGEFGNYYSLPALNDPRIDKLPYSIRILLESAIRNCDEFQVKSKDVEKILD 69

  Fly    69 WTPSLKQETS--DVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVID 131
            |     :.||  .||:.||||||:||||||||||||.|.||||:..|||:..||||:.|.|||||
plant    70 W-----ENTSPKQVEIPFKPARVLLQDFTGVPAVVDLACMRDAMNNLGGDSNKINPLVPVDLVID 129

  Fly   132 HSVQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVF 196
            ||||||..||.:|:..|..||||||||||.|||||:.||.|||:|||||||||||||||||||||
plant   130 HSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSNAFHNMLVVPPGSGIVHQVNLEYLARVVF 194

  Fly   197 ESDSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEG 261
            .::.      :||||||||||||||||:||||.|||||||||||.||||.:||:||.|:|::|.|
plant   195 NTNG------LLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLTG 253

  Fly   262 KLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDE 326
            ||....|:||||||:|:.||:.|||||||||:|.|:.|||:||||||:||.||||||:|:||:|.
plant   254 KLRDGMTATDLVLTVTQMLRKHGVVGKFVEFHGEGMRELSLADRATIANMSPEYGATMGFFPVDH 318

  Fly   327 NTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDR 391
            .||.|:|.|.||:..:.:|..||:|.:...|||..:....|:..:.|:|..|...||||||||||
plant   319 VTLQYLRLTGRSDDTVSMIEAYLRANKMFVDYSEPESKTVYSSCLELNLEDVEPCVSGPKRPHDR 383

  Fly   392 VSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNP 456
            |.:..|..|:.|||.:.|||||||:|..|.:.:.||.: :|.:.::.||.|||||||||||||||
plant   384 VPLKEMKADWHSCLDNRVGFKGFAVPKEAQSKAVEFNF-NGTTAQLRHGDVVIAAITSCTNTSNP 447

  Fly   457 SVMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIG 521
            ||||||.|:||.|...||.:.|:|||||:|||||||.||.:||:..||.||||.||||||.||||
plant   448 SVMLGAALVAKKACDLGLEVKPWIKTSLAPGSGVVTKYLAKSGLQKYLNQLGFSIVGYGCTTCIG 512

  Fly   522 NSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIE 586
            |||.:.|.|.:.|..|.||...|||||||||||:||.|||||||||.||:|||:||.||||||.:
plant   513 NSGDIHEAVASAIVDNDLVASAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTVDIDFETQ 577

  Fly   587 PLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSE 651
            |:|...:||::|.|||||:..|:.||....|:|.||:..|..|..|:..|..|.|:...||.|..
plant   578 PIGTGKDGKQIFFRDIWPSNKEVAEVVQSSVLPDMFKATYEAITKGNSMWNQLSVASGTLYEWDP 642

  Fly   652 ISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTP 716
            .||||..||:|:|||.:.|...|::.|.|||..|||:|||||||||||.:.||||:||.|||:..
plant   643 KSTYIHEPPYFKGMTMSPPGPHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLMERGVDR 707

  Fly   717 RDFNSYGSRRGNDAVMARGTFANIRLVNK-LASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLV 780
            |||||||||||||.:||||||||||:||| |..:.||.|:|:|:||::.:||||.:|.:||...:
plant   708 RDFNSYGSRRGNDEIMARGTFANIRIVNKHLKGEVGPKTVHIPTGEKLSVFDAAMKYRNEGRDTI 772

  Fly   781 LVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGR 845
            ::.|.:||||||||||||||.|||:||||::|:||||||||||||||||.|..|:.|:||.|:|:
plant   773 ILAGAEYGSGSSRDWAAKGPMLLGVKAVISKSFERIHRSNLVGMGIIPLCFKAGEDAETLGLTGQ 837

  Fly   846 EVYNIVLPE--GELKPGQRIQ-VDADGNVFETTLRFDTEVDITYYKNGGILNYMIRKML 901
            |:|.|.||.  .|:||||.:. |..:|..|..||||||||::.|:.:||||.|:||.::
plant   838 ELYTIELPNNVSEIKPGQDVTVVTNNGKSFTCTLRFDTEVELAYFDHGGILQYVIRNLI 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	542/902 (60%)
		AcnA_IRP	88..579	CDD:153136	316/490 (64%)
		AcnA_IRP_Swivel	683..852	CDD:238812	113/169 (67%)
ACO1	NP_195308.1	PLN00070	1..898	CDD:215047	542/904 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	643	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1657
Inparanoid	1	1.050	1070	1.000	Inparanoid score	I33
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	1	1.000	-	-		mtm1118
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840