DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and ACO2

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_567763.2	Gene:	ACO2 / 828805	AraportID:	AT4G26970	Length:	995	Species:	Arabidopsis thaliana

Alignment Length:	886	Identity:	525/886 - (59%)
Similarity:	655/886 - (73%)	Gaps:	15/886 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GNVYKYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVS 83
            |...||:.||:: |.:.:.||||:|:|||||:|||||:.|.:.||:.||.|.   ...|..||::
plant   117 GEYGKYYSLPALNDPRIDKLPFSVRILLESAIRNCDNYQVTKDDVEKILDWE---NTSTKQVEIA 178

  Fly    84 FKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDFVRSSDALTKN 148
            |||||||||||||||.:||.|:|||||:.||.:|.||||:.|.|||:|||:||||.||.||..||
plant   179 FKPARVILQDFTGVPVLVDLASMRDAVKNLGSDPSKINPLVPVDLVVDHSIQVDFARSEDAAQKN 243

  Fly   149 ESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILYPDSV 213
            ..|||:||||||||||||:.||.|||:||||||||||||||||.||||.|..      .||||||
plant   244 LELEFKRNKERFTFLKWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVFNSKG------FLYPDSV 302

  Fly   214 VGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLVLTITK 278
            ||||||||||:||||.|||||||||||.||||.:||:||.|:|::|:|||....|:||||||:|:
plant   303 VGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLDGKLKEGVTATDLVLTVTQ 367

  Fly   279 HLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRSEKKID 343
            .||:.|||||||||||.|::|||:||||||:||.||||||:|:||:|..||.|::.|.||::.:.
plant   368 ILRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLEYLKLTGRSDETVS 432

  Fly   344 IIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVSVSSMCEDFKSCLISP 408
            :|..||:|.....||:...|:..||..:.|||..|...:||||||||||.:..|..|:.:||.:|
plant   433 MIESYLRANNMFVDYNEPQQERAYTSYLQLDLGHVEPCISGPKRPHDRVPLKDMKADWHACLDNP 497

  Fly   409 VGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVMLGAGLLAKNAVQKG 473
            |||||||:|........:|.: :|:..:|.|||||||||||||||||||||:||.|:||.|...|
plant   498 VGFKGFAVPKEKQEEVVKFSY-NGQPAEIKHGSVVIAAITSCTNTSNPSVMIGAALVAKKASDLG 561

  Fly   474 LSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGPLDENVVNTIEKNG 538
            |.:.|::||||:|||.||..||..||:...|.:.||:||||||.|||||||.||..|.:.||...
plant   562 LKVKPWVKTSLAPGSRVVEKYLDRSGLRESLTKQGFEIVGYGCTTCIGNSGNLDPEVASAIEGTD 626

  Fly   539 LVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLGVDSNGKEVFLRDIW 603
            ::...|||||||||||:||.|||||||||.||:|||:||.||||||.||:|..|:||.|:|||:|
plant   627 IIPAAVLSGNRNFEGRVHPQTRANYLASPPLVVAYALAGTVDIDFEKEPIGTRSDGKSVYLRDVW 691

  Fly   604 PTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEISTYIKLPPFFEGMTRA 668
            |:..|:.:|....|:|:||:..|..|..|:..|..|....|.||.|...||||..||:|:.||..
plant   692 PSNEEVAQVVQYSVLPSMFKSSYETITEGNPLWNELSAPSSTLYSWDPNSTYIHEPPYFKNMTAN 756

  Fly   669 LPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMA 733
            .|..:.::.|.|||..|||||||||||||:|.:.||||::|.:||:...||||||||||||.|||
plant   757 PPGPREVKDAYCLLNFGDSVTTDHISPAGNIQKTSPAAKFLMDRGVISEDFNSYGSRRGNDEVMA 821

  Fly   734 RGTFANIRLVNK-LASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVGKDYGSGSSRDWAA 797
            ||||||||:||| |..:.||:|:|:|:||::.:||||.:|.:.....:::.|.:|||||||||||
plant   822 RGTFANIRIVNKLLKGEVGPNTVHIPTGEKLSVFDAASKYKTAEQDTIILAGAEYGSGSSRDWAA 886

  Fly   798 KGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNIVLPE--GELKPG 860
            |||.|||:|||||:|:||||||||.|||||||.|..|:.|:||.|:|.|.|.:.||.  .:::||
plant   887 KGPLLLGVKAVIAKSFERIHRSNLAGMGIIPLCFKAGEDAETLGLTGHERYTVHLPTKVSDIRPG 951

  Fly   861 QRIQVDAD-GNVFETTLRFDTEVDITYYKNGGILNYMIRKM 900
            |.:.|..| |..|..||||||||::.||.:||||.|:||.:
plant   952 QDVTVTTDSGKSFVCTLRFDTEVELAYYDHGGILPYVIRSL 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	525/886 (59%)
		AcnA_IRP	88..579	CDD:153136	310/490 (63%)
		AcnA_IRP_Swivel	683..852	CDD:238812	108/169 (64%)
ACO2	NP_567763.2	PLN00070	70..995	CDD:215047	525/886 (59%)
		AcnA_IRP	183..667	CDD:153136	310/490 (63%)
		AcnA_IRP_Swivel	771..939	CDD:238812	108/167 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	643	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1070	1.000	Inparanoid score	I33
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	1	1.000	-	-		mtm1118
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840