DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and ireb2

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_012822208.1	Gene:	ireb2 / 780221	XenbaseID:	XB-GENE-943197	Length:	984	Species:	Xenopus tropicalis

Alignment Length:	970	Identity:	491/970 - (50%)
Similarity:	645/970 - (66%)	Gaps:	91/970 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NPFAQFQE--SFTQDGNVYKYFDLPSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGW 69
            |||....|  |.|.|...:....|.:  ::|:|||:.|||:||:.|||||...|.|:|..:||.|
Frog    31 NPFHYLVEPLSGTSDKTFFNVSKLKA--TEYDSLPYCIRVVLEAVVRNCDGVLVKEQDAFNILNW 93

  Fly    70 TPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSV 134
                |......|:.|.||||:||||||:||:|||||||||:.:.|.:|:::||.||.||:.|||:
Frog    94 ----KATCEFKEIPFLPARVMLQDFTGIPAMVDFAAMRDAISKFGRDPKQVNPACPTDLIADHSL 154

  Fly   135 QVDF------------------------------------------------------------- 138
            |:||
Frog   155 QLDFTKCIVAQNVSSVPTVETHKPTTKQSPGKTLGRKAQCRSQSGCKGACELGAAHGSSREQIEN 219

  Fly   139 -----------VRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLA 192
                       :...:|..|:..:||.|||||..|.||..:||.|:.::||.:|.|||||||:|:
Frog   220 TPMLCPFHLQPIAEPEAALKSLEIEFNRNKERLQFFKWCTKAFHNVAVIPPETGTVHQVNLEFLS 284

  Fly   193 RVVFESDSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGY 257
            |||.|...      .:|||||:||||||||:||||:||.||||||:||.|||..|::.||||||.
Frog   285 RVVMEEKG------FIYPDSVLGTDSHTTMVNGLGILGLGVGGIESEAAMLGVPITLTLPEVIGC 343

  Fly   258 RLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYF 322
            .|.|.:.|||||.|:||:|||||:|.||.|.||||:|.||::||:|||.||:||||||||||.:|
Frog   344 ELTGAINPLATSIDVVLSITKHLKQAGVAGTFVEFFGNGVSQLSVADRTTIANMCPEYGATVAFF 408

  Fly   323 PIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKR 387
            |:|..||.:::||....:.:.....||:|.:.||..::  |.|:|::.:.::|:::|..||||||
Frog   409 PVDSVTLRHLKQTGVDVQSVSTFETYLQAVKLLRQENV--QQPEYSKVLQINLNSIVPYVSGPKR 471

  Fly   388 PHDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTN 452
            |.||:||..|.:||::||....|.|||.||....:......:::.: |.:.||.|||||:|||||
Frog   472 PQDRISVMDMKKDFEACLNEKTGLKGFQIPEKKQSIMVPVTYENSE-YSLSHGCVVIAAVTSCTN 535

  Fly   453 TSNPSVMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCM 517
            ..||||||.||||||.||:.||::.||||||||||||.|||||..|||:|||.:|||||:||||.
Frog   536 NCNPSVMLTAGLLAKKAVEAGLTVKPYIKTSLSPGSGTVTYYLSASGVLPYLSKLGFDIIGYGCA 600

  Fly   518 TCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDID 582
            .|:||:.||.|::|..|::..||.|||.|||::|||.......|||||||.||:|||:||.|:||
Frog   601 RCVGNTNPLPESIVTAIKEGELVACGVFSGNKHFEGNRCSCVCANYLASPPLVVAYALAGTVNID 665

  Fly   583 FEIEPLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLY 647
            .:.|.||.::.|:::|||||||:|.|:.|||...|||:||.|:..||:..:..|..|:..:|.|:
Frog   666 LQTEALGENAQGEKIFLRDIWPSREEVLEVEETMVIPSMFSELKLKIEKQNTRWNLLDAPESTLF 730

  Fly   648 PWSEISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSER 712
            ||...||:|:.||||..:.:..|.::.||||..||.|||||||||:||||||.|.||||:||.::
Frog   731 PWDLRSTFIRSPPFFHKLEKIPPPIQPIEKAHVLLYLGDSVTTDHMSPAGSIPRTSPAAKYLIQK 795

  Fly   713 GLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGT 777
            .|.||:|||||:||||||||.||||||::|.|||..||||.|.|:|||:.||:|||||.|.....
Frog   796 NLIPREFNSYGARRGNDAVMTRGTFANMKLFNKLVGKTGPKTFHLPSGQIMDVFDAAELYQKAEI 860

  Fly   778 PLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKL 842
            ||:::.||.||.|:|||||||||||||::.|||||||:||:.:||||||.|||||.|::|:||.|
Frog   861 PLIIIAGKKYGLGNSRDWAAKGPFLLGVRVVIAESYEKIHKDHLVGMGIAPLQFLSGENAETLGL 925

  Fly   843 SGREVYNIVLPEGELKPGQRIQVDAD-GNVFETTLRFDTEVDITYYKNGGILNYMIRKML 901
            |.:|.|:..||. :|.|..:|:|..: |..|.....||.|.::|:||:||||:|:.||.|
Frog   926 SAKEQYSFSLPV-DLTPRHKIEVKTNTGKTFHVIAAFDNEAEVTFYKHGGILSYVARKYL 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	490/968 (51%)
		AcnA_IRP	88..579	CDD:153136	276/562 (49%)
		AcnA_IRP_Swivel	683..852	CDD:238812	113/168 (67%)
ireb2	XP_012822208.1	PTZ00092	25..982	CDD:240263	488/966 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10823
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.030