DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and ireb2

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_005163029.1	Gene:	ireb2 / 652982	ZFINID:	ZDB-GENE-051205-1	Length:	974	Species:	Danio rerio

Alignment Length:	971	Identity:	506/971 - (52%)
Similarity:	667/971 - (68%)	Gaps:	100/971 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QFQESFTQDGNVYKYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLK 74
            |:||.        |||....: |.:||.|||.:|||||||:|.||.|:|..:||.|||.|    :
Zfish    23 QYQEQ--------KYFSPQKLNDVRYEKLPFCMRVLLESAIRKCDEFYVKTEDVSSILDW----Q 75

  Fly    75 QETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDF- 138
            .:.:..||.|.||||:||||||:||:||.||||||:.:.|.:|..:||.||.||::|||:|:|:
Zfish    76 VQQNQAEVVFSPARVLLQDFTGIPAMVDLAAMRDALAKQGVDPSLVNPRCPTDLIVDHSLQIDYS 140

  Fly   139 ----------------VRS--------------------------------SDA----------- 144
                            |:|                                |||
Zfish   141 KCGIQSPPASVDESPTVKSPAGRPSPRVSSSSGHCSGQRSGHRGGCSKPSCSDAPGGRTAAVQIE 205

  Fly   145 ------------------LTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYL 191
                              :.:|:.:|..|||||..|.||.:::|:|:.:|||....|||:|||||
Zfish   206 NTPLLCPFHLQPVSEPETMVRNQEMELIRNKERLQFFKWCSKSFNNVNVVPPDISTVHQLNLEYL 270

  Fly   192 ARVVFESDSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIG 256
            .:||.|.:.      .:|||||||||||||||||||:|||||||||:|||||||.:|:.||:|:|
Zfish   271 CKVVQEEEG------FIYPDSVVGTDSHTTMINGLGILGWGVGGIESEAVMLGQPVSLTLPQVVG 329

  Fly   257 YRLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGY 321
            .:|.|.:.|||||.|:||.|||||||.|:.||||||:||||.:||..||.||:||||||.|||.:
Zfish   330 CKLVGTINPLATSIDIVLGITKHLRQAGIGGKFVEFFGPGVPQLSAPDRTTIANMCPEYNATVSF 394

  Fly   322 FPIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPK 386
            ||:|:.||.:.:.|..||:|:.::..||||.:..|.|....::|||:|.:.::||::|..|||||
Zfish   395 FPVDDITLQHFKHTICSEEKLLVLEDYLKAVKLFRSYDDQSEEPQYSEVIEMNLSSIVPHVSGPK 459

  Fly   387 RPHDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCT 451
            ||.|||:::.|.|||.|||...||||||.|.....:....|: .||..|.:.||||||||:.|||
Zfish   460 RPQDRVAITGMKEDFISCLNEKVGFKGFHISKEKQSTLVPFR-HDGAEYNLAHGSVVIAAVISCT 523

  Fly   452 NTSNPSVMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGC 516
            |..||||||.||||||.||:.||::.|||:|||.||||.||:||..|||:|:|::|||::|||||
Zfish   524 NNCNPSVMLAAGLLAKKAVEAGLTVKPYIRTSLVPGSGTVTHYLNTSGVLPFLKKLGFEVVGYGC 588

  Fly   517 MTCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDI 581
            .||:||:.||.|:||:.:::..||.||||||||:.|||:....||||||||.||:||||||.|.|
Zfish   589 ATCVGNTAPLPESVVDAVKQGDLVACGVLSGNRHLEGRLCDCVRANYLASPPLVVAYAIAGTVSI 653

  Fly   582 DFEIEPLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKL 646
            :.|.|||||:::||:|||.|||||:.|:..:|...||.:||.|:.|:::.||..|..||.::|.|
Zfish   654 NLETEPLGVNADGKDVFLCDIWPTKEEVNHIEENIVIASMFTELRSRMEKGSSFWNNLESAESAL 718

  Fly   647 YPWSEISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSE 711
            :||...||||:.|.||..|::.:...:.|:.|..||.|||.||||||||||||||.|.||:||..
Zfish   719 FPWDPKSTYIRCPSFFSKMSKEVCSPQSIDGAYPLLFLGDKVTTDHISPAGSIARVSAAAKYLQS 783

  Fly   712 RGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEG 776
            :.||||:|||||:||||||||.|||||:|:|.|:|..||||.|||:|:|:.:|:|:|||||..:|
Zfish   784 KRLTPREFNSYGARRGNDAVMTRGTFASIKLQNRLIGKTGPKTLHIPTGQTLDVFEAAERYQRDG 848

  Fly   777 TPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLK 841
            .||:::.||:||||||||||||||:|||::||||||:|:|||::||||||.||||||||:||:|:
Zfish   849 VPLIILAGKEYGSGSSRDWAAKGPYLLGVRAVIAESFEKIHRNHLVGMGIAPLQFLPGQNADSLE 913

  Fly   842 LSGREVYNIVLPEGELKPGQRIQVD-ADGNVFETTLRFDTEVDITYYKNGGILNYMIRKML 901
            |.|:|.:.|.:|| ||...|:|.|. :.|..|..|..|:.::|:.::::||||.|:.|.:|
Zfish   914 LCGKERFTIDIPE-ELTARQQITVQTSTGKSFMVTALFENDMDVEFFRHGGILKYVARSLL 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	505/969 (52%)
		AcnA_IRP	88..579	CDD:153136	288/568 (51%)
		AcnA_IRP_Swivel	683..852	CDD:238812	117/168 (70%)
ireb2	XP_005163029.1	PTZ00092	10..973	CDD:240263	505/969 (52%)
		Aconitase	89..651	CDD:294203	288/568 (51%)
		AcnA_IRP_Swivel	755..924	CDD:238812	117/168 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10643
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.830