Protein Alignment Irp-1A and Ireb2

DIOPT Version :10

• Sequence 1: NP_477371.1
• Gene: Irp-1A / 42689
• FlyBaseID: FBgn0024958
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: XP_038938018.1
• Gene: Ireb2 / 64831
• RGDID: 621539
• Length: 964
• Species: Rattus norvegicus
• Alignment Length: 962
• Identity: 505/962 - (52%)
• Similarity: 672/962 - (69%)
• Gaps: 106/962 - (11%)

  Fly    24 KYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVSFKPA 87
            |:|::|.: .:||:.||:|||||||:||||||.|.:.::||.:||.|    |.:.|:|||.|.||
  Rat    25 KFFNVPKLGGTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVINILDW----KTKQSNVEVPFFPA 85

  Fly    88 RVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDF-------------- 138
            ||:||||||:||:|||||||:||:.|||:|:|::|.||.||.:|||:|:||
  Rat    86 RVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGG 150

  Fly   139 -----------------------------------------------------------VRSSDA 144
                                                                       |...:.
  Rat   151 DLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELSRNSGTFSSQIENTPVLCPFHLQPVPEPET 215

  Fly   145 LTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILY 209
            :.||:.:||.||:||..|.||.:.||.|:.::|||:|:.||||||:|:|||||   .||   :|:
  Rat   216 VLKNQEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQVNLEHLSRVVFE---EAD---LLF 274

  Fly   210 PDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLVL 274
            ||||:|||||.||:||||:|||||||||.||||||..:::.||||:|..|.|......||.|:||
  Rat   275 PDSVIGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVL 339

  Fly   275 TITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRSE 339
            .|||||||:||.||||||:|.||::|||.||.||:||||||||.:.:||:|..||.::..|...:
  Rat   340 GITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDK 404

  Fly   340 KKIDIIRKYLKATRQLRDYSLVDQ---DPQYTESVTLDLSTVVTSVSGPKRPHDRVSVSSMCEDF 401
            .|::.:.:||||.:..|:    |:   :|:|::.:.::|:::|.||||||||.|||:|:.|..||
  Rat   405 TKLESMEEYLKAVKLFRN----DENSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDF 465

  Fly   402 KSCLISPVGFKGFAIPPSALAASGEFQWD------DGKSYKIGHGSVVIAAITSCTNTSNPSVML 460
            ::||...||||||.:       :.|.|.|      ||..||:.||||||||:.||||..||||||
  Rat   466 QACLNEKVGFKGFQV-------AAEKQSDTVSVRYDGSEYKLSHGSVVIAAVISCTNNCNPSVML 523

  Fly   461 GAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGP 525
            .||||||.||:.||.:.|||:||||||||:||:||..|||:|||.:|||:||||||.||:||:.|
  Rat   524 AAGLLAKKAVETGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSTCVGNTAP 588

  Fly   526 LDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLGV 590
            |.|.::|.:::..||.|||||||:|||||:....||||||||.||:||||||.|:|||:.||||.
  Rat   589 LSEAILNAVKQGDLVTCGVLSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGT 653

  Fly   591 DSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEISTY 655
            ||.||.::|.||||:|.|:.::|.:|||.:||:.:..|:::|::.|.:|:..||.|:||...|||
  Rat   654 DSTGKNIYLHDIWPSREEVHQIEEEHVILSMFKALKEKVEMGNKRWNSLDAPDSVLFPWDVKSTY 718

  Fly   656 IKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFN 720
            |:.|.||:.:|:.....:.||.|..||.||||||||||||||||||.|.||:||:.||||||:||
  Rat   719 IRCPSFFDKLTKEPAASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFN 783

  Fly   721 SYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVGK 785
            |||:||||||||.|||||||:|.||...|..|.|:|.|||:.:|:|:|||.|..||.||:::.||
  Rat   784 SYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGK 848

  Fly   786 DYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNI 850
            .||||:|||||||||:|||:|||:|||||:||:.:|:|:||.||:||||::||:|.||||||:::
  Rat   849 KYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLGLSGREVFSL 913

  Fly   851 VLPEGELKPGQRIQV-DADGNVFETTLRFDTEVDITYYKNGGILNYMIRKML 901
            ..|| ||.||..:.: .:.|..|.....|:.:|:||.||:||:||::.||.|
  Rat   914 SFPE-ELFPGITLNIKTSTGKEFSVIAAFENDVEITLYKHGGLLNFVARKFL 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	504/960 (53%)
Ireb2	XP_038938018.1	PTZ00092	6..962	CDD:240263	502/958 (52%)