Protein Alignment Irp-1A and aco1

DIOPT Version :10

• Sequence 1: NP_477371.1
• Gene: Irp-1A / 42689
• FlyBaseID: FBgn0024958
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_001030155.1
• Gene: aco1 / 568448
• ZFINID: ZDB-GENE-031118-76
• Length: 890
• Species: Danio rerio
• Alignment Length: 896
• Identity: 603/896 - (67%)
• Similarity: 715/896 - (79%)
• Gaps: 13/896 - (1%)

  Fly     7 NPFAQFQESFTQDGNVYKYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWT 70
            ||:|...|........:|:|:|..: |.:||.|||||||||||||||||.|.|.:.||:.||.|.
Zfish     3 NPYAHTVEPLDPQKPDHKFFNLRKLKDPRYEQLPFSIRVLLESAVRNCDQFLVKQDDVEKILNWK 67

  Fly    71 PSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQ 135
            .:   ::..|||.|:|||||||||||||||||||||||||::|.|:||||||:||||||||||:|
Zfish    68 VT---QSQTVEVPFRPARVILQDFTGVPAVVDFAAMRDAVKKLQGDPEKINPVCPADLVIDHSIQ 129

  Fly   136 VDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDS 200
            |||.|.||:|.||:.|||:||:|||.|||||::||.||.|:||||||||||||||||||||:.|.
Zfish   130 VDFNRKSDSLQKNQDLEFERNRERFEFLKWGSKAFRNMRIIPPGSGIVHQVNLEYLARVVFDQDG 194

  Fly   201 SADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGP 265
                  ..||||:||||||||||:|||||||||||||||||||||.|||:|||||||||.|....
Zfish   195 ------FYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPEVIGYRLLGTPDK 253

  Fly   266 LATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLS 330
            ..||||:|||:||||||:|||||||||:|||||:|||||||||:|||||||||..:||:|:.::.
Zfish   254 YITSTDIVLTVTKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDQISIQ 318

  Fly   331 YMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVSVS 395
            |::||.|..:|:..|.|||||....||||...||||:|:.|.|||:||....||||||||||||:
Zfish   319 YLKQTGRDMEKLSYIEKYLKAVGMFRDYSNTAQDPQFTQVVELDLTTVEPCCSGPKRPHDRVSVA 383

  Fly   396 SMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVML 460
            .|.:||::||::..|||||.:.|........||: :|..|.:.||||||||||||||||||||||
Zfish   384 EMKKDFETCLVAKQGFKGFQVSPDRCDVQVPFQF-NGAEYSLAHGSVVIAAITSCTNTSNPSVML 447

  Fly   461 GAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGP 525
            ||||||:.|||.||::.||||||||||||||||||:||||:.:|.||||::||||||||||||||
Zfish   448 GAGLLAQKAVQAGLTVKPYIKTSLSPGSGVVTYYLKESGVMDFLSQLGFEVVGYGCMTCIGNSGP 512

  Fly   526 LDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLGV 590
            |.|.||..|.:..||..||||||||||||:||||||||||||.|||||||||.|.||||.:||.|
Zfish   513 LPEPVVEAITQGDLVAAGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKQPLAV 577

  Fly   591 DSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEISTY 655
            :|.||||:||||||||.|||.||.:.||||||:|||.|::..:..|.:|:....|||.|...|||
Zfish   578 NSEGKEVYLRDIWPTREEIQAVERQFVIPAMFKEVYEKVEKVNERWNSLKAPSDKLYTWDPNSTY 642

  Fly   656 IKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFN 720
            ||.||||:|:||.|...|.|..|..||.||||||||||||||:|||.|.|||||:.||||.|:||
Zfish   643 IKSPPFFDGLTRELQTPKPITDAYVLLNLGDSVTTDHISPAGNIARNSSAARYLTSRGLTAREFN 707

  Fly   721 SYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVGK 785
            ||||||||||||||||||||||.||..:|..|:|:::|:||.:|:|||||:|...|.||:::.||
Zfish   708 SYGSRRGNDAVMARGTFANIRLFNKFINKQSPTTIYLPTGETLDVFDAAEKYQQAGHPLLILAGK 772

  Fly   786 DYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNI 850
            :||||||||||||||||||||||:||||||||||||||||:|||::|||.||::|.|||||.|.:
Zfish   773 EYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGDSAESLGLSGRERYTV 837

  Fly   851 VLPEGELKPGQRIQVDAD-GNVFETTLRFDTEVDITYYKNGGILNYMIRKM 900
            ::|. .|||...:.:..| |..|:..:||||:|::||:.:|||||||||||
Zfish   838 MIPP-LLKPRMTVDIKLDTGKTFQARMRFDTDVELTYFHHGGILNYMIRKM 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	603/896 (67%)
aco1	NP_001030155.1	PTZ00092	3..886	CDD:240263	600/893 (67%)