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Protein Alignment Irp-1A and ACO2

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001089.1	Gene:	ACO2 / 50	HGNCID:	118	Length:	780	Species:	Homo sapiens

Alignment Length:	908	Identity:	246/908 - (27%)
Similarity:	370/908 - (40%)	Gaps:	204/908 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NVYKYFDLPSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVSFK 85
            |.|.::||         |..:|.::.:...|   ...:.||.|...|....|.:.|.....:..:
Human    40 NEYIHYDL---------LEKNINIVRKRLNR---PLTLSEKIVYGHLDDPASQEIERGKSYLRLR 92

  Fly    86 PARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQV------DFVRSSDA 144
            |.||.:||.|...|::.|         :.....|:  ..|:.:..||.::.      |..|:.|.
Human    93 PDRVAMQDATAQMAMLQF---------ISSGLSKV--AVPSTIHCDHLIEAQVGGEKDLRRAKDI 146

  Fly   145 LTKNESLEFQRNKERFTFL-----KWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADG 204
                       |:|.:.||     |:|...:      .|||||:||:.||..|
Human   147 -----------NQEVYNFLATAGAKYGVGFW------KPGSGIIHQIILENYA------------ 182

  Fly   205 SKILYPD-SVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLAT 268
                ||. .::||||||....|||.:..||||.:|..||.|....:..|:|||.:|.|.|...::
Human   183 ----YPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSS 243

  Fly   269 STDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMR 333
            ..|::|.:...|...|..|..||::||||..:|....|||.||..|.|||...||.:.....|:.
Human   244 PKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLS 308

  Fly   334 QTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRP---HDRVSVS 395
            :|.|.:        ......:.:|:.:.|....|.:.:.::||.:...::||..|   |....|.
Human   309 KTGRED--------IANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVG 365

  Fly   396 SMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVML 460
            .:.|.           :|:.:                        .:.:..|.||||:|...:..
Human   366 KVAEK-----------EGWPL------------------------DIRVGLIGSCTNSSYEDMGR 395

  Fly   461 GAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGP 525
            .|. :||.|:..||....  :.:::|||..:...:...|....|..||..::...|..|||.
Human   396 SAA-VAKQALAHGLKCKS--QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQ--- 454

  Fly   526 LDENVVNTIEKNGLVCCGVLSGNRNFEGR--IHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPL 588
            .|...:...|||.:    |.|.||||.||  .:|.|.| ::.||.:|.|.||||.:..:.|.:.|
Human   455 WDRKDIKKGEKNTI----VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYL 514

  Fly   589 -GVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEI 652
             |.|  ||:..|..  |...|:.:.|..   |.  |:.|......| ..|.::||     |.|:
Human   515 TGTD--GKKFRLEA--PDADELPKGEFD---PG--QDTYQHPPKDS-SGQHVDVS-----PTSQ- 563

  Fly   653 STYIKLPPF--FEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLT 715
             ....|.||  ::|        |.:|..:.|:.:....||||||.||.         :|..||..
Human   564 -RLQLLEPFDKWDG--------KDLEDLQILIKVKGKCTTDHISAAGP---------WLKFRGHL 610

  Fly   716 PRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLV 780
            ....|:......|   :..|...::|  |.:..:.||    ||        |.|..|...|...|
Human   611 DNISNNLLIGAIN---IENGKANSVR--NAVTQEFGP----VP--------DTARYYKKHGIRWV 658

  Fly   781 LVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGR 845
            ::..::||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|  ...||
Human   659 VIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTF--ADPAD------- 714

  Fly   846 EVYNIVLPEGEL--------KPGQRIQ--VDADGNVFETTLRFDT--EVDITYYKNGGILNYM 896
              ||.:.|..:|        .||:.::  :.......||.|...|  |..|.:::.|..||.|
Human   715 --YNKIHPVDKLTIQGLKDFTPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM 775

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.