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Protein Alignment Irp-1A and ACO1

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001265281.1	Gene:	ACO1 / 48	HGNCID:	117	Length:	889	Species:	Homo sapiens

Alignment Length:	899	Identity:	605/899 - (67%)
Similarity:	725/899 - (80%)	Gaps:	17/899 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ANPFAQFQESF--TQDGNVYKYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSIL 67
            :||||...|..  .|.|.  |:|:|..: ||:|..||||||||||:|:||||.|.|.::|:::||
Human     2 SNPFAHLAEPLDPVQPGK--KFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENIL 64

  Fly    68 GWTPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDH 132
            .|..:   :..::||.|||||||||||||||||||||||||||::|||:||||||:|||||||||
Human    65 HWNVT---QHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDH 126

  Fly   133 SVQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFE 197
            |:||||.|.:|:|.||:.|||:||:|||.|||||::||.||.|:||||||:|||||||||||||:
Human   127 SIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFD 191

  Fly   198 SDSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGK 262
            .|.      ..||||:||||||||||:|||:|||||||||||||||||.|||:||:||||||.||
Human   192 QDG------YYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGK 250

  Fly   263 LGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDEN 327
            ..||.||||:||||||||||:|||||||||:|||||:|||||||||:|||||||||..:||:||.
Human   251 PHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEV 315

  Fly   328 TLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRV 392
            :::|:.||.|.|:|:..|:|||:|....||::...|||.:|:.|.|||.|||...||||||.|:|
Human   316 SITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKV 380

  Fly   393 SVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPS 457
            :||.|.:||:|||.:..|||||.:.|........|.:|: ..:.:.|||||||||||||||||||
Human   381 AVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDN-TEFTLAHGSVVIAAITSCTNTSNPS 444

  Fly   458 VMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGN 522
            ||||||||||.||..||:::||||||||||||||||||:||||:|||.|||||:|||||||||||
Human   445 VMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGN 509

  Fly   523 SGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEP 587
            ||||.|.||..|.:..||..||||||||||||:||||||||||||.|||||||||.:.||||.||
Human   510 SGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEP 574

  Fly   588 LGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEI 652
            |||::.|::|||:||||||.|||.||.::|||.||:|||.||:..:..|..|.....||:.|:..
Human   575 LGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSK 639

  Fly   653 STYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPR 717
            |||||.|||||.:|..|...|.|..|..||.||||||||||||||:|||.|||||||:.||||||
Human   640 STYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPR 704

  Fly   718 DFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLV 782
            :||||||||||||||||||||||||:|:..:|..|.|:|:||||.:|:|||||||...|.||:::
Human   705 EFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVL 769

  Fly   783 VGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREV 847
            .||:||:|||||||||||||||||||:||||||||||||||||:|||::|||::||.|.|:|:|.
Human   770 AGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQER 834

  Fly   848 YNIVLPEGELKPGQRIQVDAD-GNVFETTLRFDTEVDITYYKNGGILNYMIRKM 900
            |.|::|| .|||..::||..| |..|:..:||||:|::||:.||||||||||||
Human   835 YTIIIPE-NLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKM 887

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.