DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and mAcon2

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	859	Identity:	242/859 - (28%)
Similarity:	359/859 - (41%)	Gaps:	173/859 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EKDVQSILGWTPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPIC 124
            ||.:.|.|....|.:.|.....:..:|.||.|||.|....::.|         :....:|:  ..
  Fly    65 EKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQF---------ISSGLKKV--AV 118

  Fly   125 PADLVIDHSVQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLE 189
            |:.:..||.::.......| |.:.:.|    |||.:.||. .|.|..|:....|||||:||:.||
  Fly   119 PSTVHCDHLIEAQISGDKD-LARAKDL----NKEVYDFLS-SACAKYNLGFWKPGSGIIHQIILE 177

  Fly   190 YLARVVFESDSSADGSKILYPD-SVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPE 253
            ..|                :|. .::||||||....|||.|..||||.:|..||......:..|.
  Fly   178 NYA----------------FPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWELKCPT 226

  Fly   254 VIGYRLEGKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGAT 318
            |||..|.||:....:..|::|.:.:.|...|..|..||::||||..:|....|||:||..|.|||
  Fly   227 VIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATITNMGAEIGAT 291

  Fly   319 VGYFPIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVS 383
            ...||.:|..::|:|.|.|.....:       ||:. :|..:.|:..:|.:.:.::|.|:...|:
  Fly   292 TSIFPFNERMVTYLRATGRGAIADE-------ATKN-KDLLVPDEGCKYDKVIEINLDTLEPLVN 348

  Fly   384 GPKRPHDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHG-SVVIAAI 447
            ||..|                        ..|.|.|.|..:.|         |.|:. .:.::.|
  Fly   349 GPFTP------------------------DLAHPISKLGQNSE---------KNGYPMEIKVSLI 380

  Fly   448 TSCTNTSNPSVMLGAGLLAKNAVQKGL-SILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDI 511
            .||||:|... |.....:|.:|:..|| |.:|:   :::|||..|...:...|:|..||:.|..:
  Fly   381 GSCTNSSYED-MGRCASIANDALGHGLKSCVPF---NVTPGSEQVRATIARDGIIDVLEKFGGTV 441

  Fly   512 VGYGCMTCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRAN-YLASPLLVIAYAI 575
            :...|..|||.   .|...|...|||.:    |.|.||||.||...|...: ::.||.:..|.||
  Fly   442 LANACGPCIGQ---WDRKDVKMGEKNTI----VTSYNRNFTGRNDANPATHCFVTSPEMATALAI 499

  Fly   576 AGRVDIDFEIEPL-GVDS--------NGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQL 631
            |||:|.:...:.| |.|.        :|:|:..:...|.....|      ..||...::...:..
  Fly   500 AGRLDFNPMTDELTGTDGKTFKLKEPHGEELPSKGFDPGEDTYQ------APPAKADDIKVNVDP 558

  Fly   632 GSRDWQTLEVSDSKLYPWSEISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPA 696
            .|...|.||..:.    | :...||.|        ..|.|:||    :|        ||||||.|
  Fly   559 KSDRLQLLEPFEK----W-DGKDYIDL--------MVLIKIKG----KC--------TTDHISAA 598

  Fly   697 GSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLAS-KTGPSTLHVPSG 760
            |.         :|..||......|:         :....|.|....:||:.: |||.
  Fly   599 GP---------WLKYRGHLDNISNN---------MFIGATNAENNEMNKVKNQKTGS-------- 637

  Fly   761 EEMDIFDA----AERYASEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNL 821
                 |||    |..|.:.......|..::||.||||:.||..|..||..|:|.:|:.|||.:||
  Fly   638 -----FDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNL 697

  Fly   822 VGMGIIPLQFL-PGQSADTLKLSGREVYNIVLPEGELKPGQRIQVDADGNVFETTLRFD---TEV 882
            ...|::.|.|. ||........|...:.|:    .:|.||:.:..:...|.....::.:   .|:
  Fly   698 KKQGMLALTFANPGDYDKVQPSSKISILNL----KDLAPGKPVDAEIKNNGSSDKIQLNHTLNEL 758

  Fly   883 DITYYKNGGILNYM 896
            .|.:::.|..||.|
  Fly   759 QIQWFQAGSALNLM 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	242/859 (28%)
		AcnA_IRP	88..579	CDD:153136	150/494 (30%)
		AcnA_IRP_Swivel	683..852	CDD:238812	51/174 (29%)
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	241/857 (28%)
		AcnA_Mitochondrial	93..503	CDD:153134	150/494 (30%)
		Aconitase_swivel	585..733	CDD:294147	56/194 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750