Protein Alignment Irp-1A and IREB2

DIOPT Version :9

• Sequence 1: NP_477371.1
• Gene: Irp-1A / 42689
• FlyBaseID: FBgn0024958
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_004127.2
• Gene: IREB2 / 3658
• HGNCID: 6115
• Length: 963
• Species: Homo sapiens
• Alignment Length: 961
• Identity: 509/961 - (52%)
• Similarity: 667/961 - (69%)
• Gaps: 98/961 - (10%)

  Fly    19 DGNVYKYFDLPSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVS 83
            |.:..|:||:..:.:||:.||:|||||||:||||||.|.:.::||.:||.|    |.:.|:|||.
Human    19 DSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDW----KTKQSNVEVP 79

  Fly    84 FKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDF---------- 138
            |.||||:||||||:||:|||||||:||:.|||:|||::|.||.||.:|||:|:||
Human    80 FFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPN 144

  Fly   139 ---------------------------------------------------------------VR 140
                                                                           |.
Human   145 PGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVP 209

  Fly   141 SSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGS 205
            ..:.:.||:.:||.||:||..|.||.:|.|.|:.::|||:|:.||:|||||:|||||.      .
Human   210 EPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEE------K 268

  Fly   206 KILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATST 270
            .:|:||||||||||.||:||||:|||||||||.||||||..:|:.||||:|..|.|...|..||.
Human   269 DLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSI 333

  Fly   271 DLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQT 335
            |:||.|||||||:||.||||||:|.||::|||.||.||:||||||||.:.:||:|..||.::..|
Human   334 DVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHT 398

  Fly   336 NRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVSVSSMCED 400
            ..|:.|::.:..||||.:..|:......:|:|::.:.::|:::|.||||||||.|||:|:.|..|
Human   399 GFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSD 463

  Fly   401 FKSCLISPVGFKGFAIPPSALAASGEFQWD------DGKSYKIGHGSVVIAAITSCTNTSNPSVM 459
            |::||...||||||.|       :.|.|.|      :|..||:.||||||||:.||||..|||||
Human   464 FQACLNEKVGFKGFQI-------AAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVM 521

  Fly   460 LGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSG 524
            |.||||||.||:.||.:.|||:||||||||:||:||..|||:|||.:|||:||||||..|:||:.
Human   522 LAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICVGNTA 586

  Fly   525 PLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLG 589
            ||.:.|:|.:::..||.||:||||:|||||:....||||||||.||:||||||.|:|||:.||||
Human   587 PLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLG 651

  Fly   590 VDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEIST 654
            .|..||.::|.||||:|.|:..||.:|||.:||:.:..||::|::.|.:||..||.|:||...||
Human   652 TDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKST 716

  Fly   655 YIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDF 719
            ||:.|.||:.:|:....|:.||.|..||.||||||||||||||||||.|.||:||:.||||||:|
Human   717 YIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREF 781

  Fly   720 NSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVG 784
            ||||:||||||||.|||||||:|.||...|..|.|:|.|||:.:|:|:|||.|..||.||:::.|
Human   782 NSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAG 846

  Fly   785 KDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYN 849
            |.||||:|||||||||:|||:|||:|||||:||:.:|:|:||.|||||||::||:|.|||||.::
Human   847 KKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFS 911

  Fly   850 IVLPEGELKPGQRIQVD-ADGNVFETTLRFDTEVDITYYKNGGILNYMIRK 899
            :..|| ||.||..:.:. :.|.||.....|:.:|:||.||:||:||::.||
Human   912 LTFPE-ELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARK 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	509/961 (53%)
		AcnA_IRP	88..579	CDD:153136	287/569 (50%)
		AcnA_IRP_Swivel	683..852	CDD:238812	116/168 (69%)
IREB2	NP_004127.2	AcnA	10..961	CDD:333196	507/959 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10470
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790