DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and aco2

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_944590.1	Gene:	aco2 / 322670	ZFINID:	ZDB-GENE-030131-1390	Length:	782	Species:	Danio rerio

Alignment Length:	849	Identity:	226/849 - (26%)
Similarity:	340/849 - (40%)	Gaps:	202/849 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 KPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDFVRSSDALTKNE 149
            :|.||.:||.|...|::.|.:        .|.|:   ...|:.:..||.::.....:.| |.|.:
Zfish    94 RPDRVAMQDATAQMAMLQFIS--------SGLPK---VAVPSTIHCDHLIEAQTGGAQD-LQKAK 146

  Fly   150 SLEFQRNKERFTFL-----KWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILY 209
            .:    |:|.::||     |:|...:      .|||||:||:.||..|                |
Zfish   147 EV----NQEVYSFLASAGAKYGVGFW------KPGSGIIHQIILENYA----------------Y 185

  Fly   210 PD-SVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLV 273
            |. .::||||||....|||.:..||||.:|..||.|....:..|.|||.:|.|.|...::..|::
Zfish   186 PGVMLIGTDSHTPNGGGLGCICIGVGGADAVDVMAGIPWELKCPNVIGVKLTGSLSGWSSPKDVI 250

  Fly   274 LTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRS 338
            |.:...|......|..||::||||..:|....|||.||..|.|||...||.:....:|:.:|.|.
Zfish   251 LKVAGILTVKRGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPFNHRMKTYLDKTGRG 315

  Fly   339 EKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRP---HDRVSVSSMCED 400
            |        ......:.:|..:.|....|.:.:.::|..:...::||..|   |....:.|:.|.
Zfish   316 E--------IATLADENKDLLVPDSGCHYDQLIEINLDELKPHINGPFTPDLAHPVSDIGSVAEK 372

  Fly   401 FKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVMLGAGLL 465
                       .|:.:                        .|.:..|.||||:|... |..|..|
Zfish   373 -----------NGWPL------------------------DVKVGLIGSCTNSSYED-MGRAASL 401

  Fly   466 AKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGPLDENV 530
            ||.|:.|||..  ..:.:::|||..:...:...|....|..:|..::...|..|||.   .|...
Zfish   402 AKQALDKGLKC--KAQFTVTPGSEQIRATIERDGYAKVLRDVGGIVLANACGPCIGQ---WDRRD 461

  Fly   531 VNTIEKNGLVCCGVLSGNRNFEGR--IHPNTRANYLASPLLVIAYAIAGRVDID----------- 582
            |...|||.:    |.|.||||..|  .:|.|.| ::.||.:|.|.||||.:..:
Zfish   462 VKKGEKNTI----VTSFNRNFTARNDANPATHA-FVTSPEIVTALAIAGTLKFNPETDYLTAPNG 521

  Fly   583 --FEIEPLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSK 645
              |::||    ..|.|:..||..|.:...|..      ||....:...:...|...|.||..|.
Zfish   522 EKFKLEP----PTGDELPARDFDPGQDTYQHP------PADGSALKVDVNPQSNRLQLLEPFDK- 575

  Fly   646 LYPWSEISTYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLS 710
               |:.                     |.:|..:.|:.:....||||||.||.         :|.
Zfish   576 ---WNG---------------------KDLEDLQVLIKVKGKCTTDHISAAGP---------WLK 607

  Fly   711 ERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASE 775
            .||        :.....|:.::......|.. ||||.        ::.:||...:.|.|..|...
Zfish   608 FRG--------HLDNISNNLLIGAVNIENDG-VNKLR--------NLLTGEYSGVPDVARHYKKN 655

  Fly   776 GTPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTL 840
            ....|:|..::||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|  ...||
Zfish   656 NISWVVVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTF--SNPAD-- 716

  Fly   841 KLSGREVYNIVLPEGELK--------PGQRIQ-----VDADGNVFETTLRFDTEVDITYYKNGGI 892
                   |:.:.|:.::.        ||:.::     .|......|....|: |..|.:::.|..
Zfish   717 -------YDKIRPDDKISIIGLKSFAPGKPLKAVIKHTDGSSETIELNHTFN-ETQIEWFQAGSA 773

  Fly   893 LNYM 896
            ||.|
Zfish   774 LNRM 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	226/849 (27%)
		AcnA_IRP	88..579	CDD:153136	143/501 (29%)
		AcnA_IRP_Swivel	683..852	CDD:238812	50/168 (30%)
aco2	NP_944590.1	aconitase_mito	47..777	CDD:273561	225/847 (27%)
		AcnA_Mitochondrial	97..507	CDD:153134	143/501 (29%)
		AcnA_Mitochon_Swivel	589..737	CDD:238810	51/184 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820