DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irp-1A and SPBP4H10.15

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_596189.3	Gene:	SPBP4H10.15 / 2541348	PomBaseID:	SPBP4H10.15	Length:	918	Species:	Schizosaccharomyces pombe

Alignment Length:	920	Identity:	233/920 - (25%)
Similarity:	385/920 - (41%)	Gaps:	187/920 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AQFQESFTQDGNVYKYFD--LPSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPS 72
            |:||.:.::...|...::  :..:....:.||.....|.|..:.:    |::..: :|..|.:|
pombe    28 ARFQSTASRASYVTPPYEKLMGKLQQVRKFLPGQKLTLAEKVLYS----HLVNPE-ESFSGVSP- 86

  Fly    73 LKQETSDVE----VSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHS 133
                 ||:.    :...|.||.:||.:...|::.|...         ..||  .:.||.:..||.
pombe    87 -----SDIRGSLYLKLNPDRVAMQDASAQMALLQFMTC---------GLEK--TMIPASIHCDHL 135

  Fly   134 VQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFES 198
            :......:||.   .:|:  ..|||.|.||:..|:.: .:....|||||:||:.||..|
pombe   136 IVGHRGANSDI---PDSI--ANNKEIFDFLQSAAKKY-GIQFWGPGSGIIHQIVLENYA------ 188

  Fly   199 DSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKL 263
               |.|..:|      ||||||....|||::..||||.:|...|......:..|::||..|.|.:
pombe   189 ---APGGMML------GTDSHTPNAGGLGMIAIGVGGADAVDAMTNTPWELKAPKIIGVNLTGAM 244

  Fly   264 GPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENT 328
            ....|..||:|.:...|...|..|..:|::|||||.||....||:.||..|.|||...||..::.
pombe   245 SGWTTPKDLILHLAGKLTVRGGTGHIIEYFGPGVASLSCTGMATVCNMGAEVGATTSIFPYTDSM 309

  Fly   329 LSYMRQTNRSE---KKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHD 390
            ..|:..|:|:|   ...::..:|        :|...|...:|.:.:.::||.:..|::||..|.
pombe   310 RRYLIATHRAEVADAASEVHSEY--------NYLAADTGAKYDQIIDINLSELTPSLNGPFTPD- 365

  Fly   391 RVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSN 455
                          |.:||...|.||..:        :|..    |:..|     .|.||||:|.
pombe   366 --------------LSTPVSKFGEAIEKN--------KWPK----KLSAG-----LIGSCTNSSY 399

  Fly   456 PSVMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCI 520
            ..:.....:: :.|:..||.  |.:...::|||..:...:...|:...||:.|..::...|..||
pombe   400 QDMTCVVDVV-EQAISAGLK--PKVPFLVTPGSEQIRATIERDGITERLEEAGATVLANACGPCI 461

  Fly   521 GNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRI--HPNTRANYLASPLLVIAYAIAGRVDIDF 583
            |.....|:  :.:.|.|.:    :.|.||||..|.  :|:| .|:|.||::|.|...:.  |:.|
pombe   462 GMWKRTDD--IASGEPNAI----LTSFNRNFRSRNDGNPST-MNFLTSPVIVAAKIFSS--DLAF 517

  Fly   584 EIEPLGVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSR-----DWQTLEVSD 643
            :                   ||...:|..:.|    |........::|.|.     |...:...:
pombe   518 D-------------------PTHDTLQTPDGK----AFKFRPPQGVELPSAGFIAGDSSYIPEPN 559

  Fly   644 SKLYPWSEISTYIK------LPPF--FEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIA 700
            .:..|.:|::...|      |.||  ::|......|:....|.:|        ||||||.||
pombe   560 PQPVPETEVTIDPKSDRLEALEPFEPYQGGEMENLKVAVKVKGKC--------TTDHISAAG--- 613

  Fly   701 RKSPAARYLSERGLTPRDFNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDI 765
                  ::|..:|                   ......|..|:..:.:.||.......:|:.|.|
pombe   614 ------KWLKYKG-------------------HLSNICNNTLIGAMNAATGEVNRAYDNGKGMTI 653

  Fly   766 FDAAERYASEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQ 830
            .:...::..:|.|.::|...:||.||:|:.||..|..:..:.::.:|:.|||.:||...|::||.
pombe   654 PELMWKWKKDGQPWLVVAEHNYGEGSAREHAALQPRAMNGRIILTKSFARIHETNLKKQGVLPLT 718

  Fly   831 FLPGQSADTL----KLSGREVYNIVLPEGEL-KPGQRIQVDADGNVFETTLRFDTEVD-ITYYKN 889
            |:.....:.:    |:|.|.:..::  ||.| :|...:....||:|.|...:.....| |.::|.
pombe   719 FVNEADYEKIDAEDKVSTRGIEQLL--EGVLDQPITLVVTKKDGSVVEIPCKHTMSKDQIEFFKA 781

  Fly   890 GGILNYMIRK 899
            |..|| :||:
pombe   782 GSALN-LIRE 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	233/920 (25%)
		AcnA_IRP	88..579	CDD:153136	141/495 (28%)
		AcnA_IRP_Swivel	683..852	CDD:238812	41/172 (24%)
SPBP4H10.15	NP_596189.3	aconitase_mito	44..788	CDD:273561	227/900 (25%)
		Aconitase	101..515	CDD:294203	141/497 (28%)
		Aconitase_swivel	599..745	CDD:294147	43/183 (23%)
		Ribosomal_L21p	820..908	CDD:279202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61122
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X803
TreeFam	0	0.000	Not matched by this tool.
	4	3.820